The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients

International Journal of Cardiology

Volumn 103, Issue 3, 2005, Pages 266-271

  Antonicelli, Roberto ^a   Olivieri, Fabiola ^a   Bonafè, Massimiliano ^b   Cavallone, Luca ^a   Spazzafumo, Liana ^a   Marchegiani, Francesca ^a   Cardelli, Maurizio ^a   Recanatini, Andrea ^a   Testarmata, Paolo ^a   Boemi, Massimo ^a   Parati, Gianfranco ^c   Franceschi, Claudio ^b  

^a INRCA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Acute coronary syndrome; IL 6 polymorphism; Inflammation; TNF polymorphism

Indexed keywords

C REACTIVE PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

AGED; ARTICLE; CARDIOVASCULAR RISK; CAUSE OF DEATH; CONTROLLED STUDY; FOLLOW UP; GENETIC POLYMORPHISM; GENOTYPE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HIGH RISK POPULATION; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; ST SEGMENT ELEVATION; SURVIVAL RATE; UNSTABLE ANGINA PECTORIS;

ACUTE DISEASE; AGED; AGED, 80 AND OVER; GENETIC MARKERS; HUMANS; INTERLEUKIN-6; MALE; MYOCARDIAL INFARCTION; PROMOTER REGIONS (GENETICS); PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; SURVIVAL ANALYSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 23644460480     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2004.08.064     Document Type: Article

References (33)

1. R. Ross Atherosclerosis: an inflammatory disease N Engl J Med 340 1999 115 126
2. B. Lindahl, H. Toss, A. Siegbahn, P. Venge, and L. Wallentin Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease. FRISC Study Group. Fragmin during Instability in Coronary Artery Disease N Engl J Med 343 2000 1139 1147
3. J.A. Berliner, M. Navab, A.M. Fogelman, J.S. Frank, L.L. Demer, and P.A. Edwards Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics Circulation 91 1995 2488 2496
4. L.M. Buja, and J.T. Willerson Role of inflammation in coronary plaque disruption Circulation 89 1994 503 505
5. A. Woods, D.J. Brull, S.E. Humphries, and H.E. Montgomery Genetics of inflammation and risk of coronary artery disease: the central role of interleukin-6 Eur Heart J 21 2000 1574 1583
6. L.M. Biasucci, G. Liuzzo, G. Fantuzzi, G. Caligiuri, A.G. Rebuzzi, and F. Ginnetti Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of-in-hospital coronary events Circulation 99 1999 2079 2084
7. E. Lindmark, E. Diderholm, L. Wallentin, and A. Siegbahn Relationship between Interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or non invasive strategy JAMA 286 2001 2107 2113
8. M. Cesari, B.W. Penninx, A.B. Newman, S.B. Kritchevsky, B.J. Nicklas, and K. Sutton-Tyrrell Inflammatory markers and onset of cardiovascular events: results from the Health ABC study Circulation 08 2003 2317 2322
9. H. Koukkunen, K. Penttila, A. Kemppainen, M. Halinen, I. Penttila, and T. Rantanen C-reactive protein, fibrinogen, interleukin-6 and tumour necrosis factor-alpha in the prognostic classification of unstable angina pectoris Ann Med 33 2001 37 47
10. L.M. Biasucci, A. Vitelli, G. Liuzzo, S. Altamura, G. Caligiuri, and C. Monaco Elevated levels of interleukin-6 in unstable angina Circulation 94 1996 874 877
11. D. Fishman, G. Faulds, R. Jeffery, V. Mohamed-Ali, J.S. Yudkin, and S. Humphries The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis J Clin Invest 102 1998 1369 1376
12. A.G. Wilson, J.A. Symons, T.L. McDowell, H.O. McDevitt, and G.W. Duff Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation Proc Natl Acad Sci U S A 94 1997 3195 3199
13. F. Olivieri, M. Bonafe, L. Cavallone, S. Giovagnetti, F. Marchegiani, and M. Cardelli The -174 G>C locus affects in vitro/in vivo IL-6 production during aging Exp Gerontol 37 2002 309 314
14. M. Bonafe, F. Olivieri, L. Cavallone, S. Giovagnetti, F. Mayegiani, and M. Cardelli A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity Eur J Immunol 31 2001 2357 2361
15. J.L. Georges, V. Loukaci, O. Poirier, A. Evans, G. Luc, and D. Arveiler Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study. Etude Cas-Temoin de l'Infarctus du Myocarde J Mol Med 79 2001 300 305
16. N.S. Jenny, R.P. Tracy, M.S. Ogg, A. Luong le, L.H. Kuller, and A.M. Arnold In the elderly, interleukin-6 plasma levels and the -174G>C polymorphism are associated with the development of cardiovascular disease Arterioscler Thromb Vasc Biol 22 2002 2066 2071
17. F. Basso, G.D. Lowe, A. Rumley, A.D. McMahon, and S.E. Humphries Interleukin-6 -174 G
18. M. Bennermo, C. Held, F. Green, L.E. Strandberg, C.G. Ericsson, and L.O. Hansson Prognostic value of plasma interleukin-6 concentrations and the -174 G>C and -572 G>C promoter polymorphisms of the interleukin-6 gene in patients with acute myocardial infarction treated with thrombolysis Atherosclerosis 174 2004 157 163
19. M. Gaudino, F. Andreotti, R. Zamparelli, A. Di Castelnuovo, G. Nasso, and F. Burzotta The -174G/C interleukin-6 polymorphism influences postoperative interleukin-6 levels and postoperative atrial fibrillation. Is atrial fibrillation an inflammatory complication? Circulation 108 Suppl 1 2003 195 199 [II]
20. J. Vendrell, J.M. Fernandez-Real, C. Gutierrez, A. Zamora, I. Simon, and A. Bardaji A polymorphism in the promoter of the tumor necrosis factor-alpha gene (-308) is associated with coronary heart disease in type 2 diabetic patients Atherosclerosis 167 2003 257 264
21. S.M. Herrmann, S. Ricard, V. Nicaud, C. Mallet, D. Arveiler, and A. Evans Polymorphisms of the tumour necrosis factor-alpha gene, coronary heart disease and obesity Eur J Clin Investig 28 1998 59 66
22. W.D. Rosamond, L.E. Chambless, A.R. Folsom, L.S. Cooper, D.E. Conwill, and L. Clegg Trends in the incidence of myocardial infarction and in mortality due to coronary heart disease, 1987-1984 New Engl J Med 339 1998 861 867
23. H. Tunstall-Pedoe, K. Kuulasmaa, M. Mahonen, H. Tolonen, E. Ruokokoski, and P. Amouyel Contributions of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations Lancet 353 1999 1547 1557
24. J.S. Alpert, K. Thygesen, E. Antman, and J.P. Bassand Myocardial infarction redefined-A consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction J Am Coll Cardiol 36 2000 959 969
25. Guidelines Committee 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension J Hypertens 21 2003 1011 1053
26. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20:1183-97.
27. O. Olomolaiye, N.A. Wood, and J.L. Bidwell A novel Nla III polymorphism in the human IL-6 promoter Eur J Immunogenet 25 1998 267
28. A.G. Wilson, F.S. di Giovine, A.I. Blakemore, and G.W. Duff Single base polymorphism in the human tumour necrosis factor alpha (TNF alpha) gene detectable by NcoI restriction of PCR product Hum Mol Genet 1 1992 353
29. J. Shepherd, S.M. Cobbe, I. Ford, C.G. Isles, A.R. Lorimer, and P.W. MacFarlane Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group N Engl J Med 333 1995 1301 1307
30. F. Mach Toward a role for statins in immunomodulation Mol Interv 2 2002 478 480
31. I.M. Rea, O.A. Ross, M. Armstrong, S. McNerlan, D.H. Alexander, and M.D. Curran Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants Mech Ageing Dev 124 2003 555 561
32. C. Franceschi, M. Bonafe, S. Valensin, F. Olivieri, M. De Luca, and E. Ottaviani Inflamm-aging. An evolutionary perspective on immunosenescence Ann N Y Acad Sci 908 2000 244 254
33. Lio D, Candore G, Crivello A, Scola L, Colonna-Romano G, Cavallone L, et al. Opposite effects of IL-10 common gene polymorphism in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. J Med Genet in press.