Vitamin D receptor agonists specifically modulate the volume of the ligand-binding pocket

Journal of Biological Chemistry

Volumn 281, Issue 15, 2006, Pages 10516-10526

  Molnár, Ferdinand ^a   Peräkylä, Mikael ^a   Carlberg, Carsten ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; COMPUTER SIMULATION; CONFORMATIONS; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; MOLECULAR DYNAMICS;

CONFORMATIONAL FLEXIBLE RESIDUES; IN VITRO ASSAYS; LIGAND-BINDING POCKET;

VITAMINS;

20 EPICALCITRIOL; 21 (3 HYDROXYMETHYLBUTYL) 23 YNE 26,27 HEXAFLUOROCALCITRIOL; 21 (3 HYDROXYMETHYLBUTYL)CALCITRIOL; ALANINE; AMINO ACID; CALCITRIOL; GEMINI; HISTIDINE; HYDROXYL GROUP; LEUCINE; RO 43 83582; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR; CALCITRIOL RECEPTOR; COMPLEMENTARY DNA; DRUG DERIVATIVE; LIGAND; LUCIFERASE; PEPTIDE HYDROLASE; RO43 83582;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DRUG MECHANISM; DRUG RECEPTOR BINDING; IN VITRO STUDY; LIGAND BINDING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; RECEPTOR AFFINITY; SIMULATION; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; DRUG POTENTIATION; GENE VECTOR; GENETIC TRANSFECTION; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; TUMOR CELL LINE;

AMINO ACIDS; CALCITRIOL; CELL LINE, TUMOR; COMPUTER SIMULATION; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; GENES, REPORTER; GENETIC VECTORS; HUMANS; LIGANDS; LUCIFERASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDE HYDROLASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CALCITRIOL; TRANSFECTION;

EID: 33744513944     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513609200     Document Type: Article

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