Central role of VDR conformations for understanding selective actions of vitamin D3 analogues

Steroids

Volumn 66, Issue 3-5, 2001, Pages 213-221

  Carlberg, Carsten ^a   Quack, Marcus ^a   Herdick, Michaela ^a   Bury, Yvonne ^a   Polly, Patsie ^a   Toell, Andrea ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Coactivators; Corepressors; Gel shift clipping assay; Limited protease digestion assay; Nuclear receptor conformations; Promoter selectivity; Protein DNA interaction; Vitamin D; Vitamin D receptor agonists; Vitamin D signalling pathways

Indexed keywords

20 EPICALCITRIOL; 20 METHYLCALCITRIOL; CALCITRIOL; CALCITRIOL DERIVATIVE; COACTIVATOR PROTEIN; COLECALCIFEROL DERIVATIVE; COREPRESSOR PROTEIN; DIMER; EB 1436; GEMINI; HETERODIMER; MONOMER; PROTEIN; RETINOID X RECEPTOR; SEOCALCITOL; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; VITAMIN D RECEPTOR AGONIST;

COMPLEX FORMATION; CONFERENCE PAPER; DNA RESPONSIVE ELEMENT; DRUG MECHANISM; NUCLEAR REACTOR; PROMOTER REGION; PROTEIN CONFORMATION; PROTEIN DNA INTERACTION; REVIEW; SIGNAL TRANSDUCTION; VITAMIN D RESPONSIVE ELEMENT;

ANIMALS; CHOLECALCIFEROL; HUMANS; PROTEIN CONFORMATION; RECEPTORS, CALCITRIOL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; TRANSCRIPTION FACTORS;

EID: 0035342670     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(00)00150-1     Document Type: Conference Paper

References (53)

1. 3
2. The vitamin D system
3. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning
4. Newly identified actions of the vitamin D endocrine system
5. Structure-function relationships in the vitamin D endocrine system
6. The nuclear receptor superfamily; the second decade
7. Anatomy of the steroid receptor zinc finger region
8. A canonical structure for the ligand-binding domain of nuclear receptors
9. The nuclear receptor ligand-binding domain; structure and function
10. Crystal structure of the RAR-γ ligand-binding domain bound to all-trans retinoic acid
11. 3 receptors
12. 3 response elements
13. The role of the T-box for the function of the vitamin D receptor on different types of response elements
14. 3 receptor in the context of the nuclear receptor superfamily; the central role of retinoid X receptor
15. 3 are associated with enhanced activation of the vitamin D receptor
16. 3 receptor
17. Selective recognition of the vitamin D receptor conformations mediates promoter selectivity of vitamin D
18. 3 analogues is not related to the AP-1 pathway, but related to promoter selectivity
19. 3 correlates well with gene activation
20. 3 receptor is functionally linked to the transactivation domain 2 (AF-2)
21. 3 analogues and their 20-epi homologues with the vitamin D receptor
22. 3 analogue is related to promoter selectivity
23. 3
24. 3 signalling
25. Conformational studies of human vitamin-D receptor by antipeptide antibodies, partial proteolytic digestion and ligand binding
26. EB1089 - a novel vitamin D analog with strong antiproliferative and differentiation inducing effects on target cells
27. The concept of multiple vitamin D pathways
28. 3 analogue EB1089 alters receptor complex formation and reduces promoter selectivity
29. Structural variants of the vitamin D analogue EB1089 reduce its ligand sensitivity and promoter selectivity
30. Metabolism of the vitamin D analog EB1089; identification of in vivo and in vitro liver metabolites and their biological activities
31. 3 receptor permits sensitive interaction with agonists
32. Increasing the complexity of coactivation in nuclear receptor signaling
33. Coactivation and corepression in transcriptional regulation by steroid/nuclear hormone receptors
34. 3 receptor identifying C-terminal amino acids required for transcriptional activation that are functionally dissociated from hormone binding, heterodimeric DNA binding, and interaction with transcription factor IIB, in vitro
35. Mapping the domains of the interaction of the vitamin D receptor and steroid receptor coactivator-1
36. The autonomous transactivation domain in helix H3 of the vitamin D receptor is required for transactivation and coactivator interaction
37. Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity
38. Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog
39. Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene
40. Steroid receptor coactivator-1 is a histone acetyltransferase
41. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
42. Composite co-activator ARC mediates chromatin-directed transcriptional activation
43. Co-activators and co-repressors in the integration of transcriptional responses
44. 3 receptor-corepressor partnership
45. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
46. Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex
47. Two nuclear signalling pathways for vitamin D
48. The vitamin D-responsive element in the human osteocalcin gene. Association with a nuclear proto-oncogene enhancer
49. Repression of basal transcription by vitamin D receptor with two receptor interaction domains in RIP13Δ1
50. A transcriptional co-repressor that interacts with nuclear hormone receptors
51. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily
52. Structural determinants of nuclear receptor assembly on DNA direct repeats