Heparin-like molecules inhibit pulmonary vascular pericyte proliferation in vitro

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 279, Issue 2 23-2, 2000, Pages

  Khoury, Joseph ^a   Langleben, David ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Cell cycle; Extracellular matrix; Proteoglycans; Pulmonary hypertension; Smooth muscle cell

Indexed keywords

5 (N,N DIMETHYL)AMILORIDE; CYCLIN DEPENDENT KINASE INHIBITOR; HEPARIN; HEPARIN DERIVATIVE; PROTEIN P21; PROTEOHEPARAN SULFATE;

ALKALINIZATION; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GROWTH REGULATION; MALE; MICROVASCULATURE; NONHUMAN; PERICYTE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER;

EID: 0033844456     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2000.279.2.l252     Document Type: Article

References (51)

1. Endothelial heparan sulfate proteoglycan. I. Inhibitory effects on smooth muscle cell proliferation
2. Spontaneously hypertensive rat vascular smooth muscle cells in culture exhibit increased growth and Na+/H+ exchange
3. Ethylisopropylamiloride-sensitive pH control mechanisms modulate vascular smooth muscle cell growth
4. Structural determinants of the capacity of heparin to inhibit the proliferation of vascular smooth muscle cells
5. Structural determinants of the capacity of heparin to inhibit the proliferation of vascular smooth muscle cells. II. Evidence for a pentasaccharide sequence that contains a 3-O-sulfate group
6. Effect of heparin on vascular smooth muscle cells. I. Cell metabolism
7. Heparin selectively inhibits a protein kinase C-dependent mechanism of cell cycle progression in calf aortic smooth muscle cells
8. Binding and internalization of heparin by vascular smooth muscle cells
9. Supression by heparin of smooth muscle proliferation in injured arteries
10. Differentiation-related mechanisms which suppress DNA replication
11. + exchange and growth of PASMC
12. Characteristics of lung pericytes in culture including their growth inhibition by endothelial substrate
13. Heparin suppresses sgk, an early response gene in proliferating vascular smooth muscle cells
14. Microvascular endothelial-derived autacoids regulate pericyte contractility
15. Immunocytochemical studies of desmin and vimentin in precapillary cells of chicken
16. Antiproliferative role of 3-O-sulfate glucosamine in heparin on cultured pulmonary artery smooth muscle cells
17. Heparinase I from Flavobacterium heparinum. Role of positive charge in enzymatic activity
18. Impairment of hypoxic pulmonary artery remodeling by heparin in mice
19. Protein kinase C-α expression is required for heparin inhibition of rat smooth muscle cell proliferation in vitro and in vivo
20. Regulation of vascular smooth muscle cell growth by endothelial-synthesized extracellular matrices
21. Inhibition of rat arterial smooth muscle cell proliferation by heparin. II. In vitro studies
22. Glycosaminoglycans: Molecular properties, protein interactions, and role in physiological processes
23. Action pattern of polysaccharide lyases on glycosaminoglycans
24. The cellular basis of microvessel restriction and neo-muscularization in pulmonary hypertension
25. α-Smooth muscle actin and microvascular precursor smooth-muscle cells in pulmonary hypertension
26. Influence on molecular weight, protein core, and charge of native heparin fractions on pulmonary artery smooth muscle cell proliferation
27. Pericytes, like vascular smooth muscle cells, are immunocytochemically positive for cyclic GMP-dependent protein kinase
28. Contractile proteins in pericytes. I. Immunoperoxidase localization of tropomyosin
29. Contractile proteins in pericytes. II. Immunocytochemical evidence for the presence of two isomyosins in graded concentrations
30. Platelet-activating factor stimulates lung pericyte growth in vitro
31. Effects of endotoxin on lung pericytes in vitro
32. Rat pulmonary artery restructuring and pulmonary hypertension induced by continuous Escherichia coli endotoxin infusion
33. Purification and characterization of heparin lyases from Flavobacterium heparinum
34. Apoptosis, oncosis, and necrosis
35. Hypoxia and incorporation of 3H-thymidine by cells of the rat pulmonary arteries and alveolar wall
36. Pulmonary hypertension: Anatomic and physiologic correlates
37. Cell specific effects of glycosaminoglycans on the attachment and proliferation of vascular wall components
38. Heparin inhibits mitogen-activated protein kinase activation in intact rat vascular smooth muscle cells
39. Inhibition of vascular smooth muscle cell proliferation in culture by pentosan polysulphate and related compounds
40. Mechanisms of inhibition by heparin of PDGF-stimulated MAP kinase activation in vascular smooth muscle cells
41. Heparin suppresses specific second messenger pathways for protooncogene expression in rat vascular smooth muscle cells
42. + exchange and growth factors in pulmonary artery smooth muscle cell proliferation
43. Amiloride analogs inhibit chronic hypoxic pulmonary hypertension
44. Recent advances in pericyte biology - Implications for health and disease
45. α-Smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes
46. Inhibition of hypoxic pulmonary hypertension by heparin of differing in vitro antiproliferative potency
47. The pulmonary vascular lesions of the adult respiratory distress syndrome
48. Structural determinants of heparin's growth inhibitory activity
49. Purification and characterization of heparinase from Flavobacterium heparinum
50. Pulmonary hypertension in severe acute respiratory failure
51. + exchange in vascular smooth muscle cells