Differential effects of HOXB4 on nonhuman primate short- and long-term repopulating cells

PLoS Medicine

Volumn 3, Issue 5, 2006, Pages 687-698

  Zhang, Xiao Bing ^a   Beard, Brian C ^a   Beebe, Katherine ^a   Storer, Barry ^a,b   Humphries, R Keith ^c,d   Kiem, Hans Peter ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c BRITISH COLUMBIA CANCER AGENCY   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; YELLOW FLUORESCENT PROTEIN; BACTERIAL PROTEIN; CD34 ANTIGEN; HOMEODOMAIN PROTEIN; PHOTOPROTEIN; TRANSCRIPTION FACTOR; YELLOW FLUORESCENT PROTEIN, BACTERIA;

ANIMAL EXPERIMENT; ARTICLE; CELL POPULATION; CONTROLLED STUDY; EX VIVO STUDY; FLOW CYTOMETRY; GENE; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HOXB4 GENE; MACACA; NONHUMAN; PROTEIN EXPRESSION; ANIMAL; ANIMAL MODEL; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; COMPARATIVE STUDY; CULTURE TECHNIQUE; GENE THERAPY; GENE VECTOR; GENETIC MARKER; GENETIC TRANSDUCTION; MACACA NEMESTRINA; PHYSIOLOGY; RETROVIRUS; STEM CELL TRANSPLANTATION; UPREGULATION;

ANIMALS; ANTIGENS, CD34; BACTERIAL PROTEINS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; GENETIC MARKERS; GENETIC THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; LUMINESCENT PROTEINS; MACACA NEMESTRINA; MODELS, ANIMAL; RETROVIRIDAE; STEM CELL TRANSPLANTATION; TRANSCRIPTION FACTORS; TRANSDUCTION, GENETIC; UP-REGULATION;

EID: 33744469807     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.0030173     Document Type: Article

References (34)

1. Ballen KK (2005) New trends in umbilical cord blood transplantation. Blood 105: 3786-3792.
2. Rocha V, Labopin M, Sanz G, Arcese W, Schwerdtfeger R, et al. Acute Leukemia Working Party of European Blood and Marrow Transplant Group, Eurocord-Netcord Registry (2004) Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med 351: 2276-2285.
3. Laughlin MJ, Eapen M, Rubinstein P, Wagner JE, Zhang MJ, et al. (2004) Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. N Engl J Med 351: 2265-2275.
4. McNiece I (2004) Ex vivo expansion of hematopoietic cells. Exp Hematol 32: 409-410.
5. Neff T, Horn PA, Peterson LJ, Thomasson BM, Thompson J, et al. (2003) Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model. J Clin Invest 112: 1581-1588.
6. Zandstra PW, Conneally E, Petzer AL, Piret JM, Eaves CJ (1997) Cytokine manipulation of primitive human hematopoietic cell self-renewal. Proc Natl Acad Sci USA 94: 4698-4703.
7. Zandstra PW, Lauffenburger DA, Eaves CJ (2000) A ligand-receptor signaling threshold model of stem cell differentiation control: A biologically conserved mechanism applicable to hematopoiesis. Blood 96: 1215-1222.
8. Bhatia M, Bonnet D, Wu D, Murdoch B, Wrana J, et al. (1999) Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells. J Exp Med 189: 1139-1148.
9. Bhatia M, Bonnet D, Kapp U, Wang JC, Murdoch B, et al. (1997) Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med 186: 619-624.
10. Dorrell C, Gan OI, Pereira DS, Hawley RG, Dick JE (2000) Expansion of human cord blood CD34(+)CD38(-) cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function. Blood 95: 102-110.
11. Gupta P, Oegema TRJ, Brazil JJ, Dudek AZ, Slungaard A, et al. (2000) Human LTC-IC can be maintained for at least 5 weeks in vitro when interleukin-3 and a single chemokine are combined with O-sulfated heparan sulfates: Requirement for optimal binding interactions of heparan sulfate with early-acting cytokines and matrix proteins. Blood 95: 147-155.
12. Breems DA, Blokland EA, Siebel KE, Mayen AE, Engels LJ, et al. (1998) Stroma-contact prevents loss of hematopoietic stem cell quality during ex vivo expansion of CD34+ mobilized peripheral blood stem cells. Blood 91: 111-117.
13. Chute JP, Saini AA, Chute DJ, Wells MR, Clark WB, et al. (2002) Ex vivo culture with human brain endothelial cells increases the SCID-repopulating capacity of adult human bone marrow. Blood 100: 4433-4439.
14. Kawano Y, Kobune M, Yamaguchi M, Nakamura K, Ito Y, et al. (2003) Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells. Blood 101: 532-540.
15. Kusadasi N, Koevoet JL, van Soest PL, Ploemacher RE (2001) Stromal support augments extended long-term ex vivo expansion of hemopoietic progenitor cells. Leukemia 15: 1347-1358.
16. Torok-Storb B, Iwata M, Graf L, Gianotti J, Horton H, et al. (1999) Dissecting the marrow microenvironment. Ann N Y Acad Sci 872: 164-170.
17. Varnum-Finney B, Xu L, Brashem-Stein C, Nourigat C, Flowers D, et al. (2000) Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch 1 signaling. Nat Med 6: 1278-1281.
18. Vercauteren SM, Sutherland HJ (2004) Constitutively active Notch4 promotes early human hematopoietic progenitor cell maintenance while inhibiting differentiation and causes lymphoid abnormalities in vivo. Blood 104: 2315-2322.
19. Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature 423: 409-414.
20. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, et al. (2003) Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423: 448-452.
21. Antonchuk J, Sauvageau G, Humphries RK (2002) HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 109: 39-45.
22. Krosl J, Austin P, Beslu N, Kroon E, Humphries RK, et al. (2003) In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat Med 9: 1428-1432.
23. Buske C, Feuring-Buske M, Abramovich C, Spiekermann K, Eaves CJ, et al. (2002) Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood 100: 862-868.
24. Schiedlmeier B, Klump H, Will E, Arman-Kalcek G, Li Z, et al. (2003) High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation. Blood 101: 1759-1768.
25. Amsellem S, Pflumio F, Bardinet D, Izac B, Charneau P, et al. (2003) Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein. Nat Med 9: 1423-1427.
26. Hawley RG, Lieu FH, Fong AZ, Hawley TS (1994) Versatile retroviral vectors for potential use in gene therapy. Gene Ther 1: 136-138.
27. Neff T, Peterson LJ, Morris JC, Thompson J, Zhang X, et al. (2004) Efficient gene transfer to hematopoietic repopulating cells using concentrated RD114-pseudotype vectors produced by human packaging cells. Mol Ther 9: 157-159.
28. Kiem HP, Andrews RG, Morris J, Peterson L, Heyward S, et al. (1998) Improved gene transfer into baboon marrow repopulating cells using recombinant human fibronectin fragment CH-296 in combination with interleukin-6, stem cell factor, FLT-3 ligand, and megakaryocyte growth and development factor. Blood 92: 1878-1886.
29. Horn PA, Topp MS, Morris JC, Riddell SR, Kiem HP (2002) Highly efficient gene transfer into baboon marrow repopulating cells using GALV-pseudotype oncoretroviral vectors produced by human packaging cells. Blood 100: 3960-3967.
30. + baboon repopulating cells. Blood 102: 3117-3119.
31. Neff T, Beard BC, Peterson LJ, Anandakumar P, Thompson J, et al. (2005) Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy. Blood 105: 997-1002.
32. Schmidt M, Carbonaro DA, Speckmann C, Wissler M, Bohnsack J, et al. (2003) Clonality analysis after retroviral-mediated gene transfer to CD34(+) cells from the cord blood of ADA-deficient SCID neonates. Nat Med 9: 463-468.
33. Morris JC, Conerly M, Thomasson B, Storek J, Riddell SR, et al. (2004) Induction of cytotoxic T-lymphocyte responses to enhanced green and yellow fluorescent proteins after myeloablative conditioning. Blood 103: 492-499.
34. Beslu N, Krosl J, Laurin M, Mayotte N, Humphries KR, et al. (2004) Molecular interactions involved in HOXB4-induced activation of HSC self-renewal. Blood 104: 2307-2314.