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Volumn 50, Issue 2, 2006, Pages 390-399

The endocannabinoid system: A new paradigm in the metabolic syndrome treatment;O sistema endocanabinóide: Novo paradigma no tratamento da síndrome metabólica

Author keywords

Endocannabinoid; Metabolic syndrome; Obesity; Rimonabant

Indexed keywords

CANNABINOID RECEPTOR; ENDOCANNABINOID;

EID: 33744469579     PISSN: 00042730     EISSN: 16779487     Source Type: Journal    
DOI: 10.1590/S0004-27302006000200025     Document Type: Review
Times cited : (9)

References (55)
  • 1
    • 0037590894 scopus 로고    scopus 로고
    • Energy balance in obesity
    • Webber J. Energy balance in obesity. Proc Nutr Soc 2003;62:539-43.
    • (2003) Proc Nutr Soc , vol.62 , pp. 539-543
    • Webber, J.1
  • 2
    • 28444462917 scopus 로고    scopus 로고
    • Epidemiologic aspects of overweight and obesity in the United States
    • Flegal KM. Epidemiologic aspects of overweight and obesity in the United States. Physiol Behav 2005;86:599-602.
    • (2005) Physiol Behav , vol.86 , pp. 599-602
    • Flegal, K.M.1
  • 3
    • 32944454527 scopus 로고    scopus 로고
    • Obesity - A critical issue in preventive cardiology: The Bogalusa Heart Study
    • Berenson GS. Obesity - a critical issue in preventive cardiology: the Bogalusa Heart Study. Prev Cardiol 2005;8:234-41.
    • (2005) Prev Cardiol , vol.8 , pp. 234-241
    • Berenson, G.S.1
  • 4
    • 33744491972 scopus 로고    scopus 로고
    • Recent advances in the development and research of CB1 antagonists
    • Smith R, Fathi Z. Recent advances in the development and research of CB1 antagonists. Drugs 2005;8:55-63.
    • (2005) Drugs , vol.8 , pp. 55-63
    • Smith, R.1    Fathi, Z.2
  • 5
    • 4544275181 scopus 로고    scopus 로고
    • The endocannabinoid system and its therapeutic exploitation
    • Di Marzo V, Bifulco M, Petrocellis L. The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Disc 2004;3:771-84.
    • (2004) Nat Rev Drug Disc , vol.3 , pp. 771-784
    • Di Marzo, V.1    Bifulco, M.2    Petrocellis, L.3
  • 6
    • 17844388556 scopus 로고    scopus 로고
    • Endocannabinoid control of food intake and energy balance
    • Di Marzo V, Matias I. Endocannabinoid control of food intake and energy balance. Nat Neurosci 2005;8:585-9.
    • (2005) Nat Neurosci , vol.8 , pp. 585-589
    • Di Marzo, V.1    Matias, I.2
  • 7
    • 33947489961 scopus 로고
    • Isolation, structure, and partial synthesis of an active constituent of hashish
    • Gaoni Y, Mechoulan R. Isolation, structure, and partial synthesis of an active constituent of hashish. J Am Chem Soc 1964;86:1646-7.
    • (1964) J Am Chem Soc , vol.86 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulan, R.2
  • 8
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990;346:561-4.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 11
    • 27144471066 scopus 로고    scopus 로고
    • Rimonabant hydrochloride: An investigational agent for the management of cardiovascular risk factors
    • Cox SL. Rimonabant hydrochloride: an investigational agent for the management of cardiovascular risk factors. Drugs Today (Barc) 2005;41:499-508.
    • (2005) Drugs Today (Barc) , vol.41 , pp. 499-508
    • Cox, S.L.1
  • 12
    • 0344505201 scopus 로고    scopus 로고
    • Drugs and immunity: Cannabinoids and their role in decreased resistance to infectious disease
    • Cabral GA, Dove Pettit DA. Drugs and immunity: cannabinoids and their role in decreased resistance to infectious disease. J Neuroimmunol 2005;83:116-23.
    • (2005) J Neuroimmunol , vol.83 , pp. 116-123
    • Cabral, G.A.1    Dove Pettit, D.A.2
  • 14
    • 1842611887 scopus 로고    scopus 로고
    • The endocannabinoid system: A general view and latest additions
    • De Petrocellis L, Cascio MG, Di Marzo V. The endocannabinoid system: a general view and latest additions. Br J Pharmacol 2004;141:765-74.
    • (2004) Br J Pharmacol , vol.141 , pp. 765-774
    • De Petrocellis, L.1    Cascio, M.G.2    Di Marzo, V.3
  • 15
    • 0035967179 scopus 로고    scopus 로고
    • Neurobiology: Cannabinoids act backwards
    • Christie MJ, Vaughan CW. Neurobiology: Cannabinoids act backwards. Nature 2001;410:527-30.
    • (2001) Nature , vol.410 , pp. 527-530
    • Christie, M.J.1    Vaughan, C.W.2
  • 16
    • 17844411014 scopus 로고    scopus 로고
    • Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH)
    • Sipe JC, Waalen J, Gerber A, Beutler E. Overweight and obesity associated with a missense polymorphism in fatty acid amide hydrolase (FAAH). Int J Obes 2005;29:755-9.
    • (2005) Int J Obes , vol.29 , pp. 755-759
    • Sipe, J.C.1    Waalen, J.2    Gerber, A.3    Beutler, E.4
  • 18
    • 0037062436 scopus 로고    scopus 로고
    • A missense mutation in human fatty acid amide hydrolase associated with problem drug use
    • Sipe JC, Chiang K, Gerber AL, Beutlar E, Cravatt BF. A missense mutation in human fatty acid amide hydrolase associated with problem drug use. PNAS 2002;99:8394-9.
    • (2002) PNAS , vol.99 , pp. 8394-8399
    • Sipe, J.C.1    Chiang, K.2    Gerber, A.L.3    Beutlar, E.4    Cravatt, B.F.5
  • 19
    • 33744454585 scopus 로고    scopus 로고
    • O sistema canabinóide
    • Godoy-Matos AF, editor. São Paulo: Atheneu
    • Godoy-Matos AF. O sistema canabinóide. In: Godoy-Matos AF, editor. Síndrome metabólica. São Paulo: Atheneu, 2005.
    • (2005) Síndrome Metabólica
    • Godoy-Matos, A.F.1
  • 20
    • 85047690626 scopus 로고    scopus 로고
    • The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
    • Cota D, Marsicano G, Tschöp M, Grübler Y, Flachskamm C, Schubert M, et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest 2003;112:423-31.
    • (2003) J Clin Invest , vol.112 , pp. 423-431
    • Cota, D.1    Marsicano, G.2    Tschöp, M.3    Grübler, Y.4    Flachskamm, C.5    Schubert, M.6
  • 21
    • 9444265979 scopus 로고    scopus 로고
    • Short communication - Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide
    • Cani PC, Montoya ML, Neyrinck AM, Delzenne NM, Lambert DM. Short communication - Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide. Br J Nutr 2004;92:757-61.
    • (2004) Br J Nutr , vol.92 , pp. 757-761
    • Cani, P.C.1    Montoya, M.L.2    Neyrinck, A.M.3    Delzenne, N.M.4    Lambert, D.M.5
  • 22
    • 0035984946 scopus 로고    scopus 로고
    • Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: Stimulation of eating by 2-arachidonoyl glycerol
    • Kirkham TC, Williams CM, Fezza F, Di Marzo V. Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br J Pharmacol 2002;136:550-7.
    • (2002) Br J Pharmacol , vol.136 , pp. 550-557
    • Kirkham, T.C.1    Williams, C.M.2    Fezza, F.3    Di Marzo, V.4
  • 23
    • 0035185205 scopus 로고    scopus 로고
    • Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats
    • Jamshidi N, Taylor DA. Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. Br J Pharmacol 2001;134:1151-4.
    • (2001) Br J Pharmacol , vol.134 , pp. 1151-1154
    • Jamshidi, N.1    Taylor, D.A.2
  • 24
    • 0035848818 scopus 로고    scopus 로고
    • Leptin-regulated endocannabinoids are involved in maintaining food intake
    • Di Marzo V, Goparaju SK, Wang L, Liu J, Batkai S, Jarai Z, et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 2001;412:822-5.
    • (2001) Nature , vol.412 , pp. 822-825
    • Di Marzo, V.1    Goparaju, S.K.2    Wang, L.3    Liu, J.4    Batkai, S.5    Jarai, Z.6
  • 25
    • 19344363569 scopus 로고    scopus 로고
    • Blood levels of the endocannabinoid anandanida are increased in anorexia nervosa and binge-eating disorder, but not in Bulimia Nervosa
    • Monteleone P, Matias I, Martiadis V, De Petrocellis L, Maj M, Di Marzo V. Blood levels of the endocannabinoid anandanida are increased in anorexia nervosa and binge-eating disorder, but not in Bulimia Nervosa. Neuropsycopharmacol 2005;30:1216-21.
    • (2005) Neuropsycopharmacol , vol.30 , pp. 1216-1221
    • Monteleone, P.1    Matias, I.2    Martiadis, V.3    De Petrocellis, L.4    Maj, M.5    Di Marzo, V.6
  • 26
    • 0036849961 scopus 로고    scopus 로고
    • A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding
    • Gomez R, Navarro M, Ferrer B, Trigo JM, Bilbao A, Del Arco I, et al. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci 2002;22:9612-27.
    • (2002) J Neurosci , vol.22 , pp. 9612-9627
    • Gomez, R.1    Navarro, M.2    Ferrer, B.3    Trigo, J.M.4    Bilbao, A.5    Del Arco, I.6
  • 28
    • 0034978249 scopus 로고    scopus 로고
    • Mechanisms of endocannabinoid inactivation: Biochemistry and pharmacology
    • Giuffrida A, Beltramo M, Piomelli D. Mechanisms of endocannabinoid inactivation: biochemistry and pharmacology. J Pharmacol Exp Ther 2001;298:7-14.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 7-14
    • Giuffrida, A.1    Beltramo, M.2    Piomelli, D.3
  • 30
    • 1842866963 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity
    • Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrie P. CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity. Int J Obes Relat Metab Disord 2004;28:640-8.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 640-648
    • Ravinet Trillou, C.1    Delgorge, C.2    Menet, C.3    Arnone, M.4    Soubrie, P.5
  • 31
    • 24644500204 scopus 로고    scopus 로고
    • The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lypolisis and energy balance
    • Jbilo O, Ravinet-Trillou C, Arnone N, Buisson I, Bribes E, et al. The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lypolisis and energy balance. FASEB J 2005;19:1567-9.
    • (2005) FASEB J , vol.19 , pp. 1567-1569
    • Jbilo, O.1    Ravinet-Trillou, C.2    Arnone, N.3    Buisson, I.4    Bribes, E.5
  • 32
    • 12444296524 scopus 로고    scopus 로고
    • Failure of fats cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type 2 diabetes mellitus
    • Heilbronn L, Smith SR, Ravussin E. Failure of fats cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type 2 diabetes mellitus. Inter J Obes 2004;28:S12-S21.
    • (2004) Inter J Obes , vol.28
    • Heilbronn, L.1    Smith, S.R.2    Ravussin, E.3
  • 33
    • 0345374579 scopus 로고    scopus 로고
    • Mini review: Weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome
    • Unger RH. Mini review: Weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 2003;144:5159-65.
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 34
    • 28044444340 scopus 로고    scopus 로고
    • Body fat distribution and insulin resistance
    • Ali AT, Crowther NJ. Body fat distribution and insulin resistance. SAMJ 2005;95:878-90.
    • (2005) SAMJ , vol.95 , pp. 878-890
    • Ali, A.T.1    Crowther, N.J.2
  • 35
    • 0037374766 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured cells
    • Bensaid M, Gary-Bobo M, Esclangon A. The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured cells. Mol Pharmacol 2003;63:908-14.
    • (2003) Mol Pharmacol , vol.63 , pp. 908-914
    • Bensaid, M.1    Gary-Bobo, M.2    Esclangon, A.3
  • 38
    • 12344332455 scopus 로고    scopus 로고
    • Cytoquines and the pathogenesis of non-alcoholic steatohepatitis
    • Diehl AM, Li ZP, Lin HZ, Iang SQ. Cytoquines and the pathogenesis of non-alcoholic steatohepatitis. Gut 2005;54:303-6.
    • (2005) Gut , vol.54 , pp. 303-306
    • Diehl, A.M.1    Li, Z.P.2    Lin, H.Z.3    Iang, S.Q.4
  • 40
    • 0034504237 scopus 로고    scopus 로고
    • Subcutaneous and visceral adipose tissue: Their relation to the metabolic syndrome
    • Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000;21:697-738.
    • (2000) Endocr Rev , vol.21 , pp. 697-738
    • Wajchenberg, B.L.1
  • 41
    • 7444227405 scopus 로고    scopus 로고
    • Intrahepatic lipids are predicted by visceral adipose tissue mass in healthy subjects
    • Thamer C, Machann J, Haap M, Stefan N, Heller E, Schnödt B, et al. Intrahepatic lipids are predicted by visceral adipose tissue mass in healthy subjects. Diabetes Care 2004;27:2726-9.
    • (2004) Diabetes Care , vol.27 , pp. 2726-2729
    • Thamer, C.1    Machann, J.2    Haap, M.3    Stefan, N.4    Heller, E.5    Schnödt, B.6
  • 43
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • Browning JD, Horton JD. Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004;114:147-52.
    • (2004) J Clin Invest , vol.114 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 44
    • 20944436157 scopus 로고    scopus 로고
    • Endocannabinoid action at hepatic CB1 receptors regulates fatty acid synthesis: Role in dietinduced obesity
    • Osei-Hyiaman D, DePetrillo M, Pacher P, Liu J, Radaeva S, Bátkai S, et al. Endocannabinoid action at hepatic CB1 receptors regulates fatty acid synthesis: role in dietinduced obesity. J Clin Invest 2005;115:1298-305.
    • (2005) J Clin Invest , vol.115 , pp. 1298-1305
    • Osei-Hyiaman, D.1    DePetrillo, M.2    Pacher, P.3    Liu, J.4    Radaeva, S.5    Bátkai, S.6
  • 45
    • 33744499865 scopus 로고    scopus 로고
    • Effects of rimonabant in the reduction of major cardiovascular risk factors. Results from the STRATUS-US Trial (Smoking Cessation in Smokers Motivated to Quit) and the RIO-Lipids Trial (Weight Reducing and Metabolic Effects in Overweight/Obese Patients with Dyslipidemia)
    • Late-Breaking Clinical Trials II. March 7-10, New Orleans, Louisiana
    • Dale L, Anthenelli R, Despres J-P, Golay A, Sjostrom L. Effects of rimonabant in the reduction of major cardiovascular risk factors. Results from the STRATUS-US Trial (Smoking Cessation in Smokers Motivated to Quit) and the RIO-Lipids Trial (Weight Reducing and Metabolic Effects in Overweight/Obese Patients with Dyslipidemia). Late-Breaking Clinical Trials II. American College of Cardiology Scientific Session 2004, March 7-10, 2004, New Orleans, Louisiana.
    • (2004) American College of Cardiology Scientific Session 2004
    • Dale, L.1    Anthenelli, R.2    Despres, J.-P.3    Golay, A.4    Sjostrom, L.5
  • 46
    • 33744492518 scopus 로고    scopus 로고
    • RIO-Europe: A randomized double-blind study of weight reducing effect and safety of rimonabant in obese patients with or without comorbidities. Hot Line I - Prevention and medical treatment I
    • August 28 - September 1, Munich, Germany
    • Van Gaal L. RIO-Europe: a randomized double-blind study of weight reducing effect and safety of rimonabant in obese patients with or without comorbidities. Hot Line I - Prevention and medical treatment I. ESC Congress 2004, August 28 - September 1, 2004, Munich, Germany.
    • (2004) ESC Congress 2004
    • Van Gaal, L.1
  • 47
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-Year experience from the RIO-Europe study
    • Van Gaal LF, Rissanen A, Scheen AJ, Ziegler O, Rössner S; the RIO-Europe Study Group. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 2005;365:1389-97.
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.2    Scheen, A.J.3    Ziegler, O.4    Rössner, S.5
  • 48
    • 27844463517 scopus 로고    scopus 로고
    • Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • Després JP, Golay A, Sjöström L, the Rimonabant in Obesity-Lipids Study group. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. NEJM 2005;353:2121-34.
    • (2005) NEJM , vol.353 , pp. 2121-2134
    • Després, J.P.1    Golay, A.2    Sjöström, L.3
  • 50
    • 0037066812 scopus 로고    scopus 로고
    • Annual smoking-attributable mortality, years of potential life lost, and economic costs - United States, 1995-1999
    • Centers for Disease Control and Prevention. Annual smoking-attributable mortality, years of potential life lost, and economic costs - United States, 1995-1999. Morb Mortal Wkly Rep 2002;51:300-3.
    • (2002) Morb Mortal Wkly Rep , vol.51 , pp. 300-303
  • 51
    • 0036893368 scopus 로고    scopus 로고
    • Smoking reduction, smoking cessation, and mortality: A 16-year follow-up of 19,732 men and women from the Copenhagen Centre for Prospective Population Studies
    • Godtfredsen NS, Holst C, Prescott E, Vestbo J, Osler M. Smoking reduction, smoking cessation, and mortality: a 16-year follow-up of 19,732 men and women from The Copenhagen Centre for Prospective Population Studies. Am J Epidemiol 2002;156:994-1001.
    • (2002) Am J Epidemiol , vol.156 , pp. 994-1001
    • Godtfredsen, N.S.1    Holst, C.2    Prescott, E.3    Vestbo, J.4    Osler, M.5
  • 52
    • 0038348902 scopus 로고    scopus 로고
    • Neuroplasticity within the mesoaccumbens dopamine system and its role in tobacco dependence
    • Balfour DJ. Neuroplasticity within the mesoaccumbens dopamine system and its role in tobacco dependence. Curr Drug Targets CNS Neurol Disord 2002;1:413-21.
    • (2002) Curr Drug Targets CNS Neurol Disord , vol.1 , pp. 413-421
    • Balfour, D.J.1
  • 53
    • 19344376599 scopus 로고    scopus 로고
    • Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A
    • De Vries TJ, De Vries W, Janssen MCW, Schoffelmeer ANM. Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A. Behav Brain Res 2005;161:164-8.
    • (2005) Behav Brain Res , vol.161 , pp. 164-168
    • De Vries, T.J.1    De Vries, W.2    Janssen, M.C.W.3    Schoffelmeer, A.N.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.