Caspase-dependant activation of chymotrypsin-like proteases mediates nuclear events during Jurkat T cell apoptosis

Biochemical and Biophysical Research Communications

Volumn 345, Issue 2, 2006, Pages 608-616

  O'Connell, A R ^a   Lee, B W ^b   Stenson Cox, C ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b Immunochemistry Technologies   (United States)

Author keywords

Apoptosis; Caspases; Fluorescent inhibitors of serine proteases; Intracellular location; Serine proteases

Indexed keywords

CASPASE; CHYMOTRYPSIN; PROTEINASE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; STAUROSPORINE;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DNA DEGRADATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; WESTERN BLOTTING;

APOPTOSIS; CASPASES; CELL NUCLEUS; CHYMOTRYPSIN; DNA FRAGMENTATION; ENZYME ACTIVATION; FLUORESCENT DYES; HUMANS; JURKAT CELLS; SERINE PROTEINASE INHIBITORS; STAUROSPORINE; SUBSTRATE SPECIFICITY;

EID: 33646826676     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.04.147     Document Type: Article

References (42)

1. Kerr J.F., Wyllie A.H., and Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26 (1972) 239-257
2. Kerr J.F. History of the events leading to the formulation of the apoptosis concept. Toxicology 181-182 (2002) 471-474
3. Green D.R., and Evan G.I. A matter of life and death. Cancer Cell 1 (2002) 19-30
4. Fuentes-Prior P., and Salvesen G.S. The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem. J. 384 (2004) 201-232
5. Nicholson D.W., and Thornberry N.A. Apoptosis. Life and death decisions. Science 299 (2003) 214-215
6. Zhivotovsky B., Samali A., Gahm A., and Orrenius S. Caspases: their intracellular localization and translocation during apoptosis. Cell Death Differ. 6 (1999) 644-651
7. Reed J.C., and Paternostro G. Postmitochondrial regulation of apoptosis during heart failure. Proc. Natl. Acad. Sci. USA 96 (1999) 7614-7616
8. Ott M., Robertson J.D., Gogvadze V., Zhivotovsky B., and Orrenius S. Cytochrome c release from mitochondria proceeds by a two-step process. Proc. Natl. Acad. Sci. USA 99 (2002) 1259-1263
9. Martinou J.C., and Green D.R. Breaking the mitochondrial barrier. Nat. Rev. Mol. Cell Biol. 2 (2001) 63-67
10. Jacotot E., Costantini P., Laboureau E., Zamzami N., Susin S.A., and Kroemer G. Mitochondrial membrane permeabilization during the apoptotic process. Ann. N. Y. Acad. Sci. 887 (1999) 18-30
11. Martin D.A., Siegel R.M., Zheng L., and Lenardo M.J. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal. J. Biol. Chem. 273 (1998) 4345-4349
12. Srinivasan A., Li F., Wong A., Kodandapani L., Smidt Jr. R., Krebs J.F., Fritz L.C., Wu J.C., and Tomaselli K.J. Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells. J. Biol. Chem. 273 (1998) 4523-4529
13. Peter M.E., and Krammer P.H. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 10 (2003) 26-35
14. Stroh C., and Schulze-Osthoff K. Death by a thousand cuts: an ever increasing list of caspase substrates. Cell Death Differ. 5 (1998) 997-1000
15. Leist M., and Jaattela M. Triggering of apoptosis by cathepsins. Cell Death Differ. 8 (2001) 324-326
16. Leist M., and Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell Biol. 2 (2001) 589-598
17. Stenson-Cox C., FitzGerald U., and Samali A. In the cut and thrust of apoptosis, serine proteases come of age. Biochem. Pharmacol. 66 (2003) 1469-1474
18. Chen S.J., Bradley M.E., and Lee T.C. Chemical hypoxia triggers apoptosis of cultured neonatal rat cardiac myocytes: modulation by calcium-regulated proteases and protein kinases. Mol. Cell Biochem. 178 (1998) 141-149
19. Gorczyca W., Bruno S., Darzynkiewicz R.J., Gong J., and Darzynkiewicz Z. DNA strand breaks occurring during apoptosis: their early in situ detection by the terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Int. J. Oncol. 1 (1992) 639-648
20. Vandenabeele P., Orrenius S., and Zhivotovsky B. Serine proteases and calpains fulfill important supporting roles in the apoptotic tragedy of the cellular opera. Cell Death Differ. 12 (2005) 1219-1224
21. Trapani J.A., and Sutton V.R. Granzyme B: pro-apoptotic, antiviral and antitumor functions. Curr. Opin. Immunol. 15 (2003) 533-543
22. Rawlings N.D., and Barrett A.J. Families of serine peptidases. Methods Enzymol. 244 (1994) 19-61
23. Suzuki Y., Imai Y., Nakayama H., Takahashi K., Takio K., and Takahashi R. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol. Cell 8 (2001) 613-621
24. Martins L.M., Iaccarino I., Tenev T., Gschmeissner S., Totty N.F., Lemoine N.R., Savopoulos J., Gray C.W., Creasy C.L., Dingwall C., and Downward J. The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. J. Biol. Chem. 277 (2002) 439-444
25. Verhagen A.M., Silke J., Ekert P.G., Pakusch M., Kaufmann H., Connolly L.M., Day C.L., Tikoo A., Burke R., Wrobel C., Moritz R.L., Simpson R.J., and Vaux D.L. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 277 (2002) 445-454
26. Hegde R., Srinivasula S.M., Zhang Z., Wassell R., Mukattash R., Cilenti L., DuBois G., Lazebnik Y., Zervos A.S., Fernandes-Alnemri T., and Alnemri E.S. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J. Biol. Chem. 277 (2002) 432-438
27. Wright S.C., Wei Q.S., Zhong J., Zheng H., Kinder D.H., and Larrick J.W. Purification of a 24-kDa protease from apoptotic tumor cells that activates DNA fragmentation. J. Exp. Med. 180 (1994) 2113-2123
28. Wright S.C., Schellenberger U., Wang H., Wang Y., and Kinder D.H. Chemotherapeutic drug activation of the AP24 protease in apoptosis: requirement for caspase 3-like-proteases. Biochem. Biophys. Res. Commun. 245 (1998) 797-803
29. Fearnhead H.O., Rivett A.J., Dinsdale D., and Cohen G.M. A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli. FEBS Lett. 357 (1995) 242-246
30. Feng Y., and LeBlanc M.H. Treatment of hypoxic-ischemic brain injury in newborn rats with TPCK 3 h after hypoxia decreases caspase-9 activation and improves neuropathologic outcome. Dev. Neurosci. 25 (2003) 34-40
31. Dong Z., Saikumar P., Patel Y., Weinberg J.M., and Venkatachalam M.A. Serine protease inhibitors suppress cytochrome c-mediatedcaspase-9 activation and apoptosis during hypoxia-reoxygenation. Biochem. J. 347 Pt. 3 (2000) 669-677
32. O'Connell A.R., Holohan C., Torriglia A., Lee B.W., and Stenson-Cox C. Characterization of a serine protease-mediated cell death program activated in human leukemia cells. Exp. Cell Res. 312 (2005) 25-37
33. Okada M., Adachi S., Imai T., Watanabe K., Toyokuni S.Y., Ueno M., Zervos A.S., Kroemer G., and Nakahata T. A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity. Blood 103 (2004) 2299-2307
34. Egger L., Schneider J., Rheme C., Tapernoux M., Hacki J., and Borner C. Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions. Cell Death Differ. 10 (2003) 1188-1203
35. Cromlish J.A., and Roeder R.G. Human transcription factor IIIC (TFIIIC). Purification, polypeptide structure, and the involvement of thiol groups in specific DNA binding. J. Biol. Chem. 264 (1989) 18100-18109
36. Grabarek J., and Darzynkiewicz Z. In situ activation of caspases and serine proteases during apoptosis detected by affinity labeling their enzyme active centers with fluorochrome-tagged inhibitors. Exp. Hematol. 30 (2002) 982-989
37. Lockshin R.A., and Zakeri Z. Caspase-independent cell death?. Oncogene 23 (2004) 2766-2773
38. Grabarek J., Ardelt B., Du L., and Darzynkiewicz Z. Activation of caspases and serine proteases during apoptosis induced by onconase (Ranpirnase). Exp. Cell Res. 278 (2002) 61-71
39. Grabarek J., Dragan M., Lee B.W., Johnson G.L., and Darzynkiewicz Z. Activation of chymotrypsin-like serine protease(s) during apoptosis detected by affinity-labeling of the enzymatic center with fluoresceinated inhibitor. Int. J. Oncol. 20 (2002) 225-233
40. Pozarowski P., Huang X., Halicka D.H., Lee B., Johnson G., and Darzynkiewicz Z. Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells: a caution in data interpretation. Cytometry A 55 (2003) 50-60
41. Grabarek J., Du L., Johnson G.L., Lee B.W., Phelps D.J., and Darzynkiewicz Z. Sequential activation of caspases and serine proteases (serpases) during apoptosis. Cell Cycle 1 (2002) 124-131
42. Schlegel J., Peters I., and Orrenius S. Isolation and partial characterization of a protease involved in Fas-induced apoptosis. FEBS Lett. 364 (1995) 139-142