Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3574-3577

  Kawai, Megumi ^a   BaMaung, Nwe Y ^a   Fidanze, Steve D ^a   Erickson, Scott A ^a   Tedrow, Jason S ^a   Sanders, William J ^a   Vasudevan, Anil ^a   Park, Chang ^a   Hutchins, Charles ^a   Comess, Kenneth M ^a   Kalvin, Douglas ^a   Wang, Jieyi ^a   Zhang, Qian ^a   Lou, Pingping ^a   Tucker Garcia, Lora ^a   Bouska, Jennifer ^a   Bell, Randy L ^a   Lesniewski, Richard ^a   Henkin, Jack ^a   Sheppard, George S ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Antiproliferative; MetAP2; Sulfonamide

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTHRANILIC ACID SULFONAMIDE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; METHIONYL AMINOPEPTIDASE; SULFONAMIDE; UNCLASSIFIED DRUG;

AFFINITY SELECTION MASS SPECTROMETRY; ARTICLE; DRUG STRUCTURE; ENZYME INHIBITION; MASS SPECTROMETRY; X RAY CRYSTALLOGRAPHY;

AMINOPEPTIDASES; ANGIOGENESIS INHIBITORS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; GLYCOPROTEINS; HUMANS; MANGANESE; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SENSITIVITY AND SPECIFICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 33646824129     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.085     Document Type: Article

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