Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 1, 2000, Pages 39-43

  Han, Cheol Kyu ^a,c   Ahn, Soon Kil ^a   Choi, Nam Song ^a   Hong, Ryung Kee ^a   Moon, Seung Kee ^a   Chun, Hyoung Sik ^a   Lee, Sang Joon ^a   Kim, Jung Woo ^a   Hong, Chung Il ^a   Kim, Deukjoon ^b   Yoon, Jeong Hyeok ^c   No, Kyoung Tai ^c  

^a Chong Kun Dang Research Institute   (South Korea)

^b Seoul National University   (South Korea)

^c Soongsil University   (South Korea)

Author keywords

Antitumor compounds; Molecular modeling mechanics

Indexed keywords

AMINOPEPTIDASE; CINNAMIC ACID DERIVATIVE; CKD 731; FUMAGILLIN; FUMAGILLOL CHLOROACETYLCARBAMATE; METHIONINE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOTHELIUM CELL; MOLECULAR INTERACTION; MOLECULAR MODEL; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; AMINOPEPTIDASES; ANGIOGENESIS INHIBITORS; ANIMALS; CATTLE; CELL LINE; CINNAMATES; CYCLOHEXANES; DRUG DESIGN; EPOXY COMPOUNDS; FATTY ACIDS, UNSATURATED; GROWTH INHIBITORS; HUMANS; LEUKEMIA P388; METALLOENDOPEPTIDASES; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0001462209     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00577-6     Document Type: Article

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