Induction of apoptosis and inhibition of NF-κB activation in human prostate cancer cells by the cis-9, trans-11 but not the trans-10, cis-12 isomer of conjugated linoleic acid

Prostate

Volumn 66, Issue 8, 2006, Pages 839-846

  Song, Hyun Ju ^a   Sneddon, Alan A ^b   Heys, Steven D ^c   Wahle, Klaus W J ^a  

^a ROBERT GORDON UNIVERSITY   (United Kingdom)

^b ROWETT RESEARCH INSTITUTE   (United Kingdom)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Apoptosis; Conjugated linoleic acids; I B phosphorylation; NF B; Prostate cancer cells

Indexed keywords

CONJUGATED LINOLEIC ACID; DNA; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; PROSTATE SPECIFIC ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN LNCAP; CONTROLLED STUDY; FLOW CYTOMETRY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; ISOMER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; REPORTER GENE; STAINING; STATISTICAL ANALYSIS; TUMOR GROWTH;

ANNEXIN A5; APOPTOSIS; CELL LINE, TUMOR; DNA, NEOPLASM; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLOW CYTOMETRY; HUMANS; I-KAPPA B PROTEINS; ISOMERISM; LINOLEIC ACIDS, CONJUGATED; MALE; NF-KAPPA B; PHOSPHORYLATION; PROSTATIC NEOPLASMS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33646736383     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.20351     Document Type: Article

References (33)

1. Parodi PW. Cow's milk fat components as potential anticarcinogenic agents. J Nutr 1997;127:1055-1060.
2. Lee KN, Kritchevsky D, Pariza MW. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 1994;108:19-12.
3. Ip C, Singh M, Thompson HJ, Scimeca JA. Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res 1994;54:1212-1215.
4. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 2000;130:2943-2948.
5. Bassaganya-Riera J, Pogranichniy RM, Jobgen SC, Halbur PG, Yoon KJ, O'Shea M, Mohede I, Hontecillas R. Conjugated linoleic aicd ameliorates viral infectivity in a pig model of virally induced immunosuppression. J Nutr 2003;133:3204-3214.
6. Henriksen EJ, Teachey MK, Taylor ZC, Jacob S, Ptock A, Kramer K, Hasselwander O. Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. Am J Physiol Endocrinol Metab 2003;285:E98-E105.
7. Song H-J, Sneddon AA, Barker PA, Bestwick C, Choe S-N, McClinton S, Grant I, Rotondo D, Heys SD, Wahle KWJ. Conjugated linoleic acid inhibits proliferation and modulates protein kinase C isoforms in human prostate cancer cells. Nutr Cancer 2004;49:100-108.
8. Cesano A, Visonneau S, Scimeca JA, Kritchevsky D, Santoli D. Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. Anticancer Res 1998;18:1429-1434.
9. Ip C, Dong Y, Thompson HJ, Bauman DE, Ip MM. Control of rat mammary epithelium proliferation by conjugated linoleic acid. Nutr Cancer 2001;39:233-238.
10. Palombo JD, Ganguly A, Bistrian BR, Menard MP. The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostate cancer cells. Cancer Lett 2002;177:163-172.
11. Majumder B, Wahle KW, Moir S, Shofield A, Choe SN, Farquharson A, Grant I, Heys D. Conjugated linoleic acids (CLAs) regulate the expression of key apoptotic gene in human breast cancer cells. FASEB J 2002;16:1447-1449.
12. Ip C, Chin SF, Scimeca JA, Pariza MW. Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res 1991;54:6118-6124.
13. Ip C, Scimeca JA. Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis. Nutr Cancer 1997;27:131-135.
14. Ochoa JJ, Farquharson AJ, Grant I, Moffat LE, Heys SD, Wahle KW. Conjugated linoleic acids (CLAs) decreased prostate cancer cell proliferation: Different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers. Carcinogenesis 2004;25:1185-1191.
15. Suh J, Rabson AB. NF-kB activation in human prostate cancer: Important mediator or epiphenomenon? J Cell Biochem 2004;91:100-117.
16. Palayoor ST, Youmell MY, Calderwood SK, Coleman CN, Price BD. Constitutive activation of Ikappa B alpha and NF-kappB in prostate cancer cells is inhibited by ibuprofen. Oncogene 1999;18:7389-7394.
17. De Moissac D, Zheng H, Kirshenbaum LA. Linkage of BH4 domain of Bcl-2 and the nuclear factor kappaB signaling pathway for supression for apoptosis. J Biol Chem 1999;274:29505-29509.
18. Simos S, Denorah S, Guoying C, Wayne AH, Dimitris T. Mechanisms by which IkB proteins control NF-kB activity. Proc Natl Acad Sci USA 1998;96:167-175.
19. Ben-Neriah Y. Regulatory functions of ubiquitination in the immune system. Nat Immunol 2002;3:20-26.
20. Traencker EB, Pahl HL, Henkel T, Schmidt KN, Wilk S, Baeuerle PA. Phosphorylation of human I kappa B-alpha on serin 32 and 36 controls IkappaB-alpha proteolysis and NF-kappaB activation in response to diverse stimuli. EMBO J 1995;14:2876-2883.
21. Beraud C, Henzel WJ, Baeuerle PA. Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation. Proc Natl Acad Sci USA 1999;96:429-434.
22. Havell EA, Fiers W, North RJ. The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity. J Exp Med 1998;167:1067-1085.
23. Wong GH, Goeddel DV. Induction of manganous superoxide dismutase by tumor necrosis factor: Possible protective mechanism. Science 1998;242:941-1944.
24. Beg AA, Baltimore D. An essential role for NF-kB in preventing TNF-alpha-induced cell death. Science 1996;274:782-784.
25. Pandian SS, Sneddon AA, Bestwick CS, McClinton S, Grant I, Wahle KWJ, Heys SD. Fatty acid regulation of protein kinase C isoforms in prostate cancer cells. Biochem Biophys Res Commun 2001;283:806-812.
26. Thiagarajan P, Tait JF. Binding of annexin V/placental anticoagulant protein I to platelet. Evidence for phosphatidylserin exposure in the procoagulant response of activated platelets. J Biol Chem 1990;265:17420-17423.
27. Brown JM, Halvorsen YD, Lea-Currie YR, Geigerman C, McIntosh M. Trans-10, cis-12, but not cis-9, trans-11, conjugated linoleic acid attenuates lipogenesis in primary cultures of stromal vascular cells from human adipose tissue. J Nutr 2001;131:2316-2321.
28. Herrmann JL, Beham AW, Sarkiss M, Chiao PJ, Rands MT, Bruckheimer EM, Brisbay S, McDonnell TJ. Bcl-2 suppresses apoptosis resulting from disruption of the NF-kB survival pathway. Exp Cell Res 1997;237:101-109.
29. Sumitomo M, Tachibana M, Nakashima J, Murai M, Miyajima A, Kimura F, Hayakawa M, Nakamura H. An essential role for nuclear factor kappaB in preventing TNF-alpha-induced cell death in prostate cancer cells. J Urol 1999;161:674-679.
30. Wooten MW, Seibenhener ML, Neidigh KBW, Vandenplas ML. Mapping of atypical protein kinase C within the nerve growth factor signalling cascade: Relationship to differenciation and survival of PC12 cells. Mol Cell Biol 2000;20:4494-4504.
31. Lallena MJ, Diaz-Meco MT, Bren GC, Paya V, Moscat J. Activation of IkB kinase b by protein kinase C isoforms. Mol Cell Biol 1999;19:2180-2188.
32. Fujii T, Garcia-Bermejo ML, Bernabo JL, Caamano J, Ohba M, Kuroki T, Li L, Yuspa SH, Kazanietz MG. Involvement of protein kinase C delta in phobol ester-induced apoptosis in LNCaP prostate cancer. J Biol Chem 2000;275:7574-7582.
33. Sumitomo M, Ohba M, Asakuma J, Asano T, Kuroki T, Asano T, Hayakawa MJ. Protein kinase C delta amplifies ceramide formation via mitochondrial signalling in prostate cancer cells. J Clin Invest 2002;109:827-836.