New derivative of 1α,25-dihydroxy-19-norvitamin D3 with 3′-alkoxypropylidene moiety at C-2: Synthesis, biological activity and conformational analysis

Journal of Steroid Biochemistry and Molecular Biology

Volumn 89-90, Issue , 2004, Pages 25-30

  Glebocka, Agnieszka ^a   Sicinski, Rafal R ^a   DeLuca, Hector F ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

19 Norvitamin D; Conformational analysis; Ligand docking to rVDR; Vitamin D compounds; Vitamin D receptor

Indexed keywords

1ALPHA,25 DIHYDROXY 2 (3' METHOXYPROPYLIDENE) 19 NORVITAMIN D3; ALKENE DERIVATIVE; CALCITRIOL DERIVATIVE; KETONE DERIVATIVE; LIGAND; PHOSPHINE OXIDE DERIVATIVE; QUINIC ACID; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; 1,25 DIHYDROXY 19 NORVITAMIN D3; 1,25-DIHYDROXY-19-NORVITAMIN D3; CALCITRIOL; CALCITRIOL RECEPTOR; DRUG DERIVATIVE;

BINDING AFFINITY; CALCIUM BLOOD LEVEL; CELL ACTIVITY; CELL DIFFERENTIATION; CELL STRAIN HL 60; COMPLEX FORMATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HORNER REACTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PROTEIN DOMAIN; RAT; ANIMAL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECT; METABOLISM; SYNTHESIS; THERMODYNAMICS;

ANIMALS; BINDING SITES; CALCITRIOL; CELL DIFFERENTIATION; HL-60 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; RATS; RECEPTORS, CALCITRIOL; THERMODYNAMICS;

EID: 4344626173     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2004.03.105     Document Type: Conference Paper

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