메뉴 건너뛰기




Volumn 46, Issue 2, 2006, Pages 68-75

Molecular approaches to developmental malformations using analogous forms of valproic acid

Author keywords

Birth defect; Malformation; Neural tube; Skeleton; Valproic acid

Indexed keywords

ANTICONVULSIVE AGENT; VALNOCTAMIDE; VALPROIC ACID; VALPROIC ACID DERIVATIVE; VALPROMIDE;

EID: 33646716238     PISSN: 09143505     EISSN: 17414520     Source Type: Journal    
DOI: 10.1111/j.1741-4520.2006.00105.x     Document Type: Review
Times cited : (7)

References (96)
  • 1
    • 0029891279 scopus 로고    scopus 로고
    • A role of mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton
    • Akasaka T, Kanno M, Balling R, Mieza MA, Taniguchi M, Koseki H 1996 A role of mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development 122 : 1513 1522.
    • (1996) Development , vol.122 , pp. 1513-1522
    • Akasaka, T.1    Kanno, M.2    Balling, R.3    Mieza, M.A.4    Taniguchi, M.5    Koseki, H.6
  • 3
    • 0028347278 scopus 로고
    • The teratogenic effects of valproic acid in human chondrogenesis in vitro
    • Aulthouse AL, Hitt DC 1994 The teratogenic effects of valproic acid in human chondrogenesis in vitro. Teratology 49 : 208 217.
    • (1994) Teratology , vol.49 , pp. 208-217
    • Aulthouse, A.L.1    Hitt, D.C.2
  • 4
    • 0030907689 scopus 로고    scopus 로고
    • Stereoselective pharmacokinetic analysis of valnoctamide in healthy subjects and epileptic patients
    • Barel S, Yagen B, Schurig V et al. 1997 Stereoselective pharmacokinetic analysis of valnoctamide in healthy subjects and epileptic patients. Clin Pharmacol Ther 61 : 442 449.
    • (1997) Clin Pharmacol Ther , vol.61 , pp. 442-449
    • Barel, S.1    Yagen, B.2    Schurig, V.3
  • 5
    • 0034282815 scopus 로고    scopus 로고
    • Developmental toxicity of valproic acid during embryonic chick vertebral chondrogenesis
    • Basu A, Wezeman FH 2000 Developmental toxicity of valproic acid during embryonic chick vertebral chondrogenesis. Spine 25 : 2158 2164.
    • (2000) Spine , vol.25 , pp. 2158-2164
    • Basu, A.1    Wezeman, F.H.2
  • 6
    • 0034663218 scopus 로고    scopus 로고
    • Altered retinoic acid sensitivity and temporal expression of Hox genes in Polycomb-M33-deficient mice
    • Bel-Vialar S, Coré N, Terranova R, Goudot V, Boned A, Djabali M 2000 Altered retinoic acid sensitivity and temporal expression of Hox genes in Polycomb-M33-deficient mice. Dev Biol 224 : 238 249.
    • (2000) Dev Biol , vol.224 , pp. 238-249
    • Bel-Vialar, S.1    Coré, N.2    Terranova, R.3    Goudot, V.4    Boned, A.5    Djabali, M.6
  • 8
    • 0026015881 scopus 로고
    • Clinical Pharmacology of valpromide
    • Bialer M 1991 Clinical Pharmacology of valpromide. Clin Pharmacokinet 20 : 114 122.
    • (1991) Clin Pharmacokinet , vol.20 , pp. 114-122
    • Bialer, M.1
  • 9
    • 0032863679 scopus 로고    scopus 로고
    • Pharmacokinetic considerations in the design of better and safer new antiepileptic drugs
    • Bialer M 1999 Pharmacokinetic considerations in the design of better and safer new antiepileptic drugs. J Control Release 62 : 187 192.
    • (1999) J Control Release , vol.62 , pp. 187-192
    • Bialer, M.1
  • 10
    • 0025262283 scopus 로고
    • Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects
    • Bialer M, Haj-Yehia A, Barzaghi N, Pisani F, Perucca E 1990 Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects. Eur J Pharmacol 38 : 289 291.
    • (1990) Eur J Pharmacol , vol.38 , pp. 289-291
    • Bialer, M.1    Haj-Yehia, A.2    Barzaghi, N.3    Pisani, F.4    Perucca, E.5
  • 11
    • 77957183374 scopus 로고
    • Evaluation of valproic acid (VPA) developmental toxicity and pharmacokinetics in Sprague-Dawley rats
    • Binkerd PE, Rowland JM, Nau H, Hendrickx AG 1988 Evaluation of valproic acid (VPA) developmental toxicity and pharmacokinetics in Sprague-Dawley rats. Fundam Appl Toxicol 11 : 485 493.
    • (1988) Fundam Appl Toxicol , vol.11 , pp. 485-493
    • Binkerd, P.E.1    Rowland, J.M.2    Nau, H.3    Hendrickx, A.G.4
  • 12
    • 0029979326 scopus 로고    scopus 로고
    • Disposition of valpromide, valproic acid and valnoctamide in the brain, liver, plasma, and urine of rats
    • Blotnik S, Bergman F, Bialer M 1996 Disposition of valpromide, valproic acid and valnoctamide in the brain, liver, plasma, and urine of rats. Drug Metab Dispos 24 : 560 564.
    • (1996) Drug Metab Dispos , vol.24 , pp. 560-564
    • Blotnik, S.1    Bergman, F.2    Bialer, M.3
  • 13
    • 0141814680 scopus 로고    scopus 로고
    • Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1) - Deficient mice
    • Cheng HL, Mostoslavsky R, Saito S et al. 2003 Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1) - deficient mice. Proc Natl Acad Sci USA 100 : 10794 10799.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10794-10799
    • Cheng, H.L.1    Mostoslavsky, R.2    Saito, S.3
  • 14
    • 0026773897 scopus 로고
    • Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development
    • Coccia EM, Cicala C, Charlesworth A et al. 1992 Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development. Mol Cell Biol 12 : 3514 3521.
    • (1992) Mol Cell Biol , vol.12 , pp. 3514-3521
    • Coccia, E.M.1    Cicala, C.2    Charlesworth, A.3
  • 15
    • 0036788729 scopus 로고    scopus 로고
    • Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with AF9 after chromosomal translocation in leukemia
    • Collins EC, Appert A, Ariza-McNaughton L, Pannell R, Yamada Y, Rabbitts TH 2002 Mouse Af9 is a controller of embryo patterning, like Mll, whose human homologue fuses with AF9 after chromosomal translocation in leukemia. Mol Cell Biol 22 : 7313 7324.
    • (2002) Mol Cell Biol , vol.22 , pp. 7313-7324
    • Collins, E.C.1    Appert, A.2    Ariza-Mcnaughton, L.3    Pannell, R.4    Yamada, Y.5    Rabbitts, T.H.6
  • 16
    • 0026348985 scopus 로고
    • The effect of administration time on malformations induced by three anticonvulsant agents in C57BL/6J mice with emphasis on forelimb ectrodactyly
    • Collins MD, Walling KM, Resnick E, Scott Jr WJ 1991 The effect of administration time on malformations induced by three anticonvulsant agents in C57BL/6J mice with emphasis on forelimb ectrodactyly. Teratology 44 : 617 627.
    • (1991) Teratology , vol.44 , pp. 617-627
    • Collins, M.D.1    Walling, K.M.2    Resnick, E.3    Scott Jr., W.J.4
  • 17
    • 0023709064 scopus 로고
    • A cell-type-specific abnormality of cell proliferation in mutant (curly tail) mouse embryo developing spinal neural tube defects
    • Copp AJ, Brook FA, Roberts HJ 1988 A cell-type-specific abnormality of cell proliferation in mutant (curly tail) mouse embryo developing spinal neural tube defects. Development 104 : 285 295.
    • (1988) Development , vol.104 , pp. 285-295
    • Copp, A.J.1    Brook, F.A.2    Roberts, H.J.3
  • 18
    • 0031049215 scopus 로고    scopus 로고
    • Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice
    • Coré N, Bel S, Gaunt SJ et al. 1997 Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice. Development 124 : 721 729.
    • (1997) Development , vol.124 , pp. 721-729
    • Coré, N.1    Bel, S.2    Gaunt, S.J.3
  • 19
    • 0034088711 scopus 로고    scopus 로고
    • Ribonucleotide reductase subunit r1: A gene conferring sensitivity to valproic acid-induced neural tube defects in mice
    • Craig JC, Bennett GD, Miranda RC, Mackler SA, Finnell RH 2000 Ribonucleotide reductase subunit r1: A gene conferring sensitivity to valproic acid-induced neural tube defects in mice. Teratology 61 : 305 313.
    • (2000) Teratology , vol.61 , pp. 305-313
    • Craig, J.C.1    Bennett, G.D.2    Miranda, R.C.3    MacKler, S.A.4    Finnell, R.H.5
  • 20
    • 0026281619 scopus 로고
    • Parental epilepsy, anticonvulsant drugs, and reproductive outcome: Epidemiologic and experimental findings spanning three decades; 2: Human studies
    • Dansky LV, Finnell RH 1991 Parental epilepsy, anticonvulsant drugs, and reproductive outcome: Epidemiologic and experimental findings spanning three decades; 2: Human studies. Reprod Toxicol 5 : 301 335.
    • (1991) Reprod Toxicol , vol.5 , pp. 301-335
    • Dansky, L.V.1    Finnell, R.H.2
  • 21
    • 0026758356 scopus 로고
    • The growth arrest-specific gene, gas1, is involved in growth suppression
    • Del Sal G, Ruaro ME, Philipson L, Schneider C 1992 The growth arrest-specific gene, gas1, is involved in growth suppression. Cell 70 : 595 607.
    • (1992) Cell , vol.70 , pp. 595-607
    • Del Sal, G.1    Ruaro, M.E.2    Philipson, L.3    Schneider, C.4
  • 22
    • 0036843033 scopus 로고    scopus 로고
    • Of meis and men: Lessons from a microarray study of teratogen action
    • Docterman KE, Smith SM 2002 of meis and men: Lessons from a microarray study of teratogen action. Teratology 66 : 217 223.
    • (2002) Teratology , vol.66 , pp. 217-223
    • Docterman, K.E.1    Smith, S.M.2
  • 23
    • 0032880120 scopus 로고    scopus 로고
    • Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality
    • Donohoe ME, Zhang X, McGinnis L, Biggers J, Li E, Shi Y 1999 Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol 19 : 7237 7244.
    • (1999) Mol Cell Biol , vol.19 , pp. 7237-7244
    • Donohoe, M.E.1    Zhang, X.2    McGinnis, L.3    Biggers, J.4    Li, E.5    Shi, Y.6
  • 24
    • 0026556607 scopus 로고
    • Valproic aid-induced spina bifida: A mouse model
    • Ehlers K, Stürje H, Merker HJ, Nau H 1992 Valproic aid-induced spina bifida: A mouse model. Teratology 45 : 145 154.
    • (1992) Teratology , vol.45 , pp. 145-154
    • Ehlers, K.1    Stürje, H.2    Merker, H.J.3    Nau, H.4
  • 25
    • 0033968253 scopus 로고    scopus 로고
    • A mouse model for valproate teratogenicity: Parental effects, homeotic transformations, and altered HOX expression
    • Faiella A, Wernig M, Consalez GG et al. 2000 A mouse model for valproate teratogenicity: Parental effects, homeotic transformations, and altered HOX expression. Hum Mol Genet 9 : 227 236.
    • (2000) Hum Mol Genet , vol.9 , pp. 227-236
    • Faiella, A.1    Wernig, M.2    Consalez, G.G.3
  • 26
    • 0026303466 scopus 로고
    • Parental epilepsy, anticonvulsant drugs, and reproductive outcome: Epidemiologic and experimental findings spanning three decades; 1: Animal studies
    • Finnell RH, Dansky LV 1991 Parental epilepsy, anticonvulsant drugs, and reproductive outcome: Epidemiologic and experimental findings spanning three decades; 1: Animal studies. Reprod Toxicol 5 : 281 299.
    • (1991) Reprod Toxicol , vol.5 , pp. 281-299
    • Finnell, R.H.1    Dansky, L.V.2
  • 27
    • 0037636320 scopus 로고    scopus 로고
    • Pathobiology and genetics of neural tube defects
    • Finnell RH, Gould A, Spiegelstein O 2003 Pathobiology and genetics of neural tube defects. Epilepsia 44 Suppl. 3 14 23.
    • (2003) Epilepsia , vol.443 , pp. 14-23
    • Finnell, R.H.1    Gould, A.2    Spiegelstein, O.3
  • 29
    • 0031006579 scopus 로고    scopus 로고
    • Histone acetylation influences thyroid hormone and retinoic acid-mediated gene expression
    • Garcia-Villalba P, Jimenez-Lara AM, Castillo AI, Aranda A 1997 Histone acetylation influences thyroid hormone and retinoic acid-mediated gene expression. DNA Cell Biol 16 : 421 431.
    • (1997) DNA Cell Biol , vol.16 , pp. 421-431
    • Garcia-Villalba, P.1    Jimenez-Lara, A.M.2    Castillo, A.I.3    Aranda, A.4
  • 30
    • 0035861202 scopus 로고    scopus 로고
    • The molecular biology of the SIR proteins
    • Gasser SM, Cockell MM 2001 The molecular biology of the SIR proteins. Gene 279 : 1 16.
    • (2001) Gene , vol.279 , pp. 1-16
    • Gasser, S.M.1    Cockell, M.M.2
  • 31
    • 0027461863 scopus 로고
    • Intermittent pattern of neural tube closure in two strains of mice
    • Golden JA, Chernoff GF 1993 Intermittent pattern of neural tube closure in two strains of mice. Teratology 47 : 73 80.
    • (1993) Teratology , vol.47 , pp. 73-80
    • Golden, J.A.1    Chernoff, G.F.2
  • 32
    • 18244383806 scopus 로고    scopus 로고
    • Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
    • Göttlicher M, Minucci S, Zhu P et al. 2001 Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J 20 : 6969 6978.
    • (2001) EMBO J , vol.20 , pp. 6969-6978
    • Göttlicher, M.1    Minucci, S.2    Zhu, P.3
  • 33
    • 0030772115 scopus 로고    scopus 로고
    • Functions of mammalian Polycomb group and trithorax group related genes
    • Gould A 1997 Functions of mammalian Polycomb group and trithorax group related genes. Curr Opin Genet Dev 7 : 488 494.
    • (1997) Curr Opin Genet Dev , vol.7 , pp. 488-494
    • Gould, A.1
  • 34
    • 0034193776 scopus 로고    scopus 로고
    • Sir2 links chromatin silencing, metabolism, and aging
    • Guarente L 2000 Sir2 links chromatin silencing, metabolism, and aging. Genes Dev 14 : 1021 1026.
    • (2000) Genes Dev , vol.14 , pp. 1021-1026
    • Guarente, L.1
  • 35
    • 0024266719 scopus 로고
    • Pharmacokinetics of a valpromide isomer, valnoctamide, in dogs
    • Haj-Yehia A, Bialer M 1988 Pharmacokinetics of a valpromide isomer, valnoctamide, in dogs. J Pharm Sci 77 : 831 834.
    • (1988) J Pharm Sci , vol.77 , pp. 831-834
    • Haj-Yehia, A.1    Bialer, M.2
  • 36
    • 0024440860 scopus 로고
    • Structure-pharmacokinetic relationships in a series of valpromide derivatives with antiepileptic activity
    • Haj-Yehia A, Bialer M 1989 Structure-pharmacokinetic relationships in a series of valpromide derivatives with antiepileptic activity. Pharm Res 8 : 683 689.
    • (1989) Pharm Res , vol.8 , pp. 683-689
    • Haj-Yehia, A.1    Bialer, M.2
  • 37
    • 0033503556 scopus 로고    scopus 로고
    • Mini-review: Toward understanding mechanisms of genetic neural tube defects in mice
    • Harris MJ, Juriloff DM 1999 Mini-review: Toward understanding mechanisms of genetic neural tube defects in mice. Teratology 60 : 292 305.
    • (1999) Teratology , vol.60 , pp. 292-305
    • Harris, M.J.1    Juriloff, D.M.2
  • 38
    • 0023697903 scopus 로고
    • Valproic acid developmental toxicity and pharmacokinetics in the rhesus monkey: An interspecies comparison
    • Hendrickx AG, Nau H, Binkerd P et al. 1988 Valproic acid developmental toxicity and pharmacokinetics in the rhesus monkey: An interspecies comparison. Teratology 38 : 329 345.
    • (1988) Teratology , vol.38 , pp. 329-345
    • Hendrickx, A.G.1    Nau, H.2    Binkerd, P.3
  • 39
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • Imai S, Armstrong CM, Kaeberlein M, Guarente L 2000 Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403 : 795 800.
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1    Armstrong, C.M.2    Kaeberlein, M.3    Guarente, L.4
  • 40
    • 0042125466 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships of 2S,3S-valnocatmide and its stereoisomer 2R,3S-valnoctamide in animal model for epilepsy
    • Isoherranen N 2003 Pharmacokinetic-pharmacodynamic relationships of 2S,3S-valnocatmide and its stereoisomer 2R,3S-valnoctamide in animal model for epilepsy. Pharm Res 20 : 1293 1301.
    • (2003) Pharm Res , vol.20 , pp. 1293-1301
    • Isoherranen, N.1
  • 41
    • 0036126054 scopus 로고    scopus 로고
    • Anticonvulsant profile and teratogenicity of N-methyl- tetramethylcyclopropyl carboxamide: A new antiiepileptic drug
    • Isoherranen N, White HS, Finnell RH et al. 2002 Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: A new antiiepileptic drug. Epilepsia 43 : 115 126.
    • (2002) Epilepsia , vol.43 , pp. 115-126
    • Isoherranen, N.1    White, H.S.2    Finnell, R.H.3
  • 42
    • 0242499953 scopus 로고    scopus 로고
    • New CNS-active drugs which are second-generation valproic acid: Can they lead to the development of a magic bullet?
    • Isoherranen N, Yagen B, Bialer M 2003 New CNS-active drugs which are second-generation valproic acid: Can they lead to the development of a magic bullet? Curr Opin Neurol 16 : 203 211.
    • (2003) Curr Opin Neurol , vol.16 , pp. 203-211
    • Isoherranen, N.1    Yagen, B.2    Bialer, M.3
  • 43
    • 0038066627 scopus 로고    scopus 로고
    • Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: A role of histone deacetylase inhibition
    • Jeong MR, Hashimoto R, Senatorov VV et al. 2003 Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: A role of histone deacetylase inhibition. FEBS Lett 542 : 74 78.
    • (2003) FEBS Lett , vol.542 , pp. 74-78
    • Jeong, M.R.1    Hashimoto, R.2    Senatorov, V.V.3
  • 46
    • 0027478594 scopus 로고
    • Transcriptional activation of Drosophila homeotic genes from distant regulatory elements
    • Kennison JA 1993 Transcriptional activation of Drosophila homeotic genes from distant regulatory elements. Trends Genet 9 : 75 79.
    • (1993) Trends Genet , vol.9 , pp. 75-79
    • Kennison, J.A.1
  • 47
    • 0026772226 scopus 로고
    • Respecification of vertebral identities by retinoic acid
    • Kessel M 1992 Respecification of vertebral identities by retinoic acid. Development 115 : 487 501.
    • (1992) Development , vol.115 , pp. 487-501
    • Kessel, M.1
  • 48
    • 0025941823 scopus 로고
    • Homeotic transformation of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid
    • Kessel M, Gruss P 1991 Homeotic transformation of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 67 : 89 104.
    • (1991) Cell , vol.67 , pp. 89-104
    • Kessel, M.1    Gruss, P.2
  • 50
    • 0026794938 scopus 로고
    • Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6
    • Langston AW, Gudas LJ 1992 Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6. Mech Dev 38 : 217 227.
    • (1992) Mech Dev , vol.38 , pp. 217-227
    • Langston, A.W.1    Gudas, L.J.2
  • 51
    • 0034492526 scopus 로고    scopus 로고
    • In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model for focal epilepsy
    • Lindekens H, Smolders I, Khan GM, Bialer M, Ebinger G, Michotte Y 2000 In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model for focal epilepsy. Pharm Res 17 : 1408 1413.
    • (2000) Pharm Res , vol.17 , pp. 1408-1413
    • Lindekens, H.1    Smolders, I.2    Khan, G.M.3    Bialer, M.4    Ebinger, G.5    Michotte, Y.6
  • 52
    • 0030218039 scopus 로고    scopus 로고
    • The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression
    • van der Lugt NMT, Alkema M, Berns A, Deschamps J 1996 The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. Mech Dev 58 : 153 164.
    • (1996) Mech Dev , vol.58 , pp. 153-164
    • Van Der Lugt, N.M.T.1    Alkema, M.2    Berns, A.3    Deschamps, J.4
  • 53
    • 0034531408 scopus 로고    scopus 로고
    • Loss- and gain-of-function mutations show a Polycomb group function for Ring1A in mice
    • del Mar Lorente M, Marcos-Gutiérrez C, Pérez C et al. 2000 Loss- and gain-of-function mutations show a Polycomb group function for Ring1A in mice. Development 127 : 5093 5100.
    • (2000) Development , vol.127 , pp. 5093-5100
    • Del Mar Lorente, M.1    Marcos-Gutiérrez, C.2    Pérez, C.3
  • 54
    • 0037207475 scopus 로고    scopus 로고
    • The mammalian SIR2α protein has a role in embryogenesis and gametogenesis
    • McBurney MW, Yang X, Jardine K et al. 2003 The mammalian SIR2α protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 23 : 38 54.
    • (2003) Mol Cell Biol , vol.23 , pp. 38-54
    • McBurney, M.W.1    Yang, X.2    Jardine, K.3
  • 56
    • 0031886987 scopus 로고    scopus 로고
    • Stage-dependent skeletal malformations induced by valproic acid in rat
    • Menegola E, Broccia ML, Prati M, Giavini E 1998 Stage-dependent skeletal malformations induced by valproic acid in rat. Int J Dev Biol 42 : 99 102.
    • (1998) Int J Dev Biol , vol.42 , pp. 99-102
    • Menegola, E.1    Broccia, M.L.2    Prati, M.3    Giavini, E.4
  • 57
    • 27644527117 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity on specific embryonic tissues as s new mechanism for teratogenicity
    • Menegola E, Di Renzo F, Broccia ML et al. 2005 Inhibition of histone deacetylase activity on specific embryonic tissues as s new mechanism for teratogenicity. Birth Defects Res Part B Dev Reprod Toxicol 74 : 392 398.
    • (2005) Birth Defects Res Part B Dev Reprod Toxicol , vol.74 , pp. 392-398
    • Menegola, E.1    Di Renzo, F.2    Broccia, M.L.3
  • 59
    • 0026001902 scopus 로고
    • Valproic acid-induced neural tube defects in mouse and human: Aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms
    • Nau H, Hauck RS, Ehlers K 1991 Valproic acid-induced neural tube defects in mouse and human: Aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms. Pharmacol Toxicol 69 : 310 321.
    • (1991) Pharmacol Toxicol , vol.69 , pp. 310-321
    • Nau, H.1    Hauck, R.S.2    Ehlers, K.3
  • 61
    • 77957179936 scopus 로고
    • Pharmacologic evaluation of various metabolites and analogs of valproic acid: Teratogenic potencies in mice
    • Nau H, Löscher W 1986 Pharmacologic evaluation of various metabolites and analogs of valproic acid: Teratogenic potencies in mice. Fundam Appl Toxicol 6 : 669 676.
    • (1986) Fundam Appl Toxicol , vol.6 , pp. 669-676
    • Nau, H.1    Löscher, W.2
  • 62
    • 0023063107 scopus 로고
    • Teratogenicity of valproic acid and related substances in the mouse: Drug accumulation and pH in the embryo during organogenesis and structure-activity considerations
    • Nau H, Scott WJ 1987 Teratogenicity of valproic acid and related substances in the mouse: Drug accumulation and pH in the embryo during organogenesis and structure-activity considerations. Arch Toxicol 11 : 128 139.
    • (1987) Arch Toxicol , vol.11 , pp. 128-139
    • Nau, H.1    Scott, W.J.2
  • 66
    • 18144374152 scopus 로고    scopus 로고
    • Identification of early responsive genes correlated to valproic acid induced neural tube defects in mice
    • Okada A, Kushima K, Aoki Y, Bialer M, Fujiwara M 2005a Identification of early responsive genes correlated to valproic acid induced neural tube defects in mice. Birth Defects Res Part A Clin Mol Teratol 73 : 229 238.
    • (2005) Birth Defects Res Part a Clin Mol Teratol , vol.73 , pp. 229-238
    • Okada, A.1    Kushima, K.2    Aoki, Y.3    Bialer, M.4    Fujiwara, M.5
  • 67
    • 24944451116 scopus 로고    scopus 로고
    • Phenytoin stimulates chondrogenic differentiation in mouse clonal chondrogenic EC cells, ATDC5
    • Okada A, Shiomi T, Aoki Y, Fujiwara M 2005b Phenytoin stimulates chondrogenic differentiation in mouse clonal chondrogenic EC cells, ATDC5. J Txicol Sci 30 : 145 156.
    • (2005) J Txicol Sci , vol.30 , pp. 145-156
    • Okada, A.1    Shiomi, T.2    Aoki, Y.3    Fujiwara, M.4
  • 69
    • 0030250887 scopus 로고    scopus 로고
    • Sodium valproate augments spontaneous neural tube defects and axial skeletal malformations in to mouse fetuses
    • Padmanabhan R, Ahmed I 1996 Sodium valproate augments spontaneous neural tube defects and axial skeletal malformations in TO mouse fetuses. Reprod Toxicol 10 : 345 363.
    • (1996) Reprod Toxicol , vol.10 , pp. 345-363
    • Padmanabhan, R.1    Ahmed, I.2
  • 70
    • 0028080907 scopus 로고
    • Exencephaly and axial skeletal malformations induced by maternal administration of sodium valproate in the MF1 mouse
    • Padmanabhan R, Hameed MS 1994 Exencephaly and axial skeletal malformations induced by maternal administration of sodium valproate in the MF1 mouse. J Craniofac Genet Dev Biol 14 : 192 205.
    • (1994) J Craniofac Genet Dev Biol , vol.14 , pp. 192-205
    • Padmanabhan, R.1    Hameed, M.S.2
  • 71
    • 0025202707 scopus 로고
    • Imprinting a determined state into the chromatin of Drosophila
    • Paro R 1990 Imprinting a determined state into the chromatin of Drosophila. Trends Genet 6 : 416 421.
    • (1990) Trends Genet , vol.6 , pp. 416-421
    • Paro, R.1
  • 73
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS 2001 Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem 276 : 36734 36741.
    • (2001) J Biol Chem , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 74
    • 0030802589 scopus 로고    scopus 로고
    • Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression
    • Pirotta V 1997 Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression. Trends Genet 13 : 314 318.
    • (1997) Trends Genet , vol.13 , pp. 314-318
    • Pirotta, V.1
  • 75
    • 0027471014 scopus 로고
    • Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene
    • Popperl H, Featherstone MS 1993 Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene. Mol Cell Biol 13 : 257 265.
    • (1993) Mol Cell Biol , vol.13 , pp. 257-265
    • Popperl, H.1    Featherstone, M.S.2
  • 76
    • 0031912815 scopus 로고    scopus 로고
    • Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid
    • Radatz M, Ehlers K, Yagen B, Bialer M, Nau H 1998 Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid. Epilepsy Res 30 : 41 48.
    • (1998) Epilepsy Res , vol.30 , pp. 41-48
    • Radatz, M.1    Ehlers, K.2    Yagen, B.3    Bialer, M.4    Nau, H.5
  • 79
    • 0023765743 scopus 로고
    • Genes specifically expressed at growth arrest of mammalian cells
    • Schneider C, King RM, Philipson L 1988 Genes specifically expressed at growth arrest of mammalian cells. Cell 54 : 787 793.
    • (1988) Cell , vol.54 , pp. 787-793
    • Schneider, C.1    King, R.M.2    Philipson, L.3
  • 80
    • 0029841672 scopus 로고    scopus 로고
    • Positional cloning of a global regulator of anterior-posterior patterning in mice
    • Schumacher A, Faust C, Magnuson T 1996 Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature 383 : 250 253.
    • (1996) Nature , vol.383 , pp. 250-253
    • Schumacher, A.1    Faust, C.2    Magnuson, T.3
  • 81
    • 0025980567 scopus 로고
    • Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells
    • Simeone A, Acampoca D, Negro V et al. 1991 Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma cells. Mech Dev 33 : 215 227.
    • (1991) Mech Dev , vol.33 , pp. 215-227
    • Simeone, A.1    Acampoca, D.2    Negro, V.3
  • 82
    • 0028569767 scopus 로고
    • Interaction of the p53-regulated protein GADD45 with proliferating nuclear cell antigen
    • Smith ML, Chen IT, Zhan Q et al. 1994 Interaction of the p53-regulated protein GADD45 with proliferating nuclear cell antigen. Science 266 : 1376 1379.
    • (1994) Science , vol.266 , pp. 1376-1379
    • Smith, M.L.1    Chen, I.T.2    Zhan, Q.3
  • 83
    • 3843141802 scopus 로고    scopus 로고
    • Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives
    • Sobol E, Bialer M, Yagen B 2004 Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives. J Med Chem 47 : 4316 4326.
    • (2004) J Med Chem , vol.47 , pp. 4316-4326
    • Sobol, E.1    Bialer, M.2    Yagen, B.3
  • 84
    • 0036744627 scopus 로고    scopus 로고
    • Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice
    • Suzuki M, Mizutani-Koseki Y, Fujimura Y et al. 2002 Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development 129 : 4171 4183.
    • (2002) Development , vol.129 , pp. 4171-4183
    • Suzuki, M.1    Mizutani-Koseki, Y.2    Fujimura, Y.3
  • 85
    • 0030729636 scopus 로고    scopus 로고
    • Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects
    • Takihara Y, Tomotsune D, Shirai M et al. 1997 Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development 124 : 3673 3682.
    • (1997) Development , vol.124 , pp. 3673-3682
    • Takihara, Y.1    Tomotsune, D.2    Shirai, M.3
  • 86
    • 0034333494 scopus 로고    scopus 로고
    • Regulation of Hoxb3 expression in the hindbrain and pharyngeal arches by rae28, a member of the mammalian Polyomb group of genes
    • Tomotsune D, Shirai M, Takihara Y, Shimada K 2000 Regulation of Hoxb3 expression in the hindbrain and pharyngeal arches by rae28, a member of the mammalian Polyomb group of genes. Mech Dev 98 : 165 169.
    • (2000) Mech Dev , vol.98 , pp. 165-169
    • Tomotsune, D.1    Shirai, M.2    Takihara, Y.3    Shimada, K.4
  • 87
    • 0030734789 scopus 로고    scopus 로고
    • Identification of a growth arrest specific (gas5) gene by differential display as a candidate gene for determining susceptibility to hyperthermia-induced exencephaly in mice
    • Vacha SJ, Bennett GD, Mackler SA, Koebbe MJ, Finnell RH 1997 Identification of a growth arrest specific (gas5) gene by differential display as a candidate gene for determining susceptibility to hyperthermia-induced exencephaly in mice. Dev Genet 21 : 212 222.
    • (1997) Dev Genet , vol.21 , pp. 212-222
    • Vacha, S.J.1    Bennett, G.D.2    MacKler, S.A.3    Koebbe, M.J.4    Finnell, R.H.5
  • 88
    • 0028201742 scopus 로고
    • Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene
    • van der Lugt NMT, Domen J, Linders K et al. 1994 Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene. Genes Dev 8 : 757 769.
    • (1994) Genes Dev , vol.8 , pp. 757-769
    • Van Der Lugt, N.M.T.1    Domen, J.2    Linders, K.3
  • 89
    • 0032751323 scopus 로고    scopus 로고
    • Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
    • van der Vlag J, Otte AP 1999 Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat Genet 23 : 474 478.
    • (1999) Nat Genet , vol.23 , pp. 474-478
    • Van Der Vlag, J.1    Otte, A.P.2
  • 90
    • 0023273582 scopus 로고
    • Teratogenicity and developmental toxicity of valproic acid in rats
    • Vorhees CV 1987 Teratogenicity and developmental toxicity of valproic acid in rats. Teratology 35 : 195 202.
    • (1987) Teratology , vol.35 , pp. 195-202
    • Vorhees, C.V.1
  • 91
    • 0036707815 scopus 로고    scopus 로고
    • The mouse PcG gene eed is required for Hox gene repression and extraembryonic development
    • Wang J, Mager J, Schnedier E, Magnuson T 2002 The mouse PcG gene eed is required for Hox gene repression and extraembryonic development. Mamm Genome 13 : 493 503.
    • (2002) Mamm Genome , vol.13 , pp. 493-503
    • Wang, J.1    Mager, J.2    Schnedier, E.3    Magnuson, T.4
  • 92
    • 0015348474 scopus 로고
    • Congenital malformations of the central nervous system in rats produced by maternal zinc deficiency
    • Warkany J, Petering HG 1972 Congenital malformations of the central nervous system in rats produced by maternal zinc deficiency. Teratology 5 : 319 334.
    • (1972) Teratology , vol.5 , pp. 319-334
    • Warkany, J.1    Petering, H.G.2
  • 93
    • 0016054422 scopus 로고
    • Proliferation in the neural tube of the splotch (Sp) mutant mouse
    • Wilson DB 1974 Proliferation in the neural tube of the splotch (Sp) mutant mouse. J Comp Neurol 154 : 249 256.
    • (1974) J Comp Neurol , vol.154 , pp. 249-256
    • Wilson, D.B.1
  • 94
    • 0016143015 scopus 로고
    • Neural cell cycle in the Looptail mutant of the mouse (Lp)
    • Wilson DB, Center EM 1974 Neural cell cycle in the Looptail mutant of the mouse (Lp). J Embryol Exp Morphol 32 : 697 705.
    • (1974) J Embryol Exp Morphol , vol.32 , pp. 697-705
    • Wilson, D.B.1    Center, E.M.2
  • 95
    • 0030292878 scopus 로고    scopus 로고
    • Arsenic-induced neural tube defects in mice: Alterations in cell cycle and gene expression
    • Wlodarczyk BJ, Bennett GD, Calvin JA, Finnell RH 1996 Arsenic-induced neural tube defects in mice: Alterations in cell cycle and gene expression. Reprod Toxicol 10 : 447 454.
    • (1996) Reprod Toxicol , vol.10 , pp. 447-454
    • Wlodarczyk, B.J.1    Bennett, G.D.2    Calvin, J.A.3    Finnell, R.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.