Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: A new antiepileptic drug

Epilepsia

Volumn 43, Issue 2, 2002, Pages 115-126

  Isoherranen, Nina ^a   White, H Steve ^c   Finnell, Richard H ^d   Yagen, Boris ^a,b   Woodhead, José H ^c   Bennett, Gregory D ^e   Wilcox, Karen S ^c   Barton, Matthew E ^c   Bialer, Meir ^a,b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c UNIVERSITY OF UTAH   (United States)

^d TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Animal model; Antiepileptic activity; Central nervous system (CNS) active cyclopropyl valproylamide analogue; Neural tube defects

Indexed keywords

ANTICONVULSIVE AGENT; BICUCULLINE; DRUG METABOLITE; N METHYL TETRAMETHYLCYCLOPROPYL CARBOXAMIDE; PENTETRAZOLE; TETRAMETHYLCYCLOPROPYL CARBOXAMIDE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; ELECTRIC SHOCK; EVALUATION; GRAND MAL SEIZURE; MALE; MOUSE; NEURAL TUBE DEFECT; NEUROTOXICITY; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; RAT; TERATOGENESIS;

ACOUSTIC STIMULATION; ADMINISTRATION, ORAL; AMIDES; ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; BICUCULLINE; CONVULSANTS; CYCLOPROPANES; ELECTROPHYSIOLOGY; ELECTROSHOCK; EPILEPSY; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED STRAINS; MUTAGENICITY TESTS; NEURAL TUBE DEFECTS; PENTYLENETETRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES;

EID: 0036126054     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1528-1157.2002.25801.x     Document Type: Article

References (34)

1. Valproic acid: Clinical use
2. Valproic acid: Toxicity
3. Fluorinated analogues as mechanistic probes in valproic acid hepatotoxicity: Hepatic microvesicular steatosis and glutathione status
4. Toxic metabolites of valproic acid: Inhibition of rat liver acetoacetyl-CoA thiolase by 2-n-propyl pentenoic acid (Δ4-VPA) and related branched-chain carboxylic acids
5. Congenital malformations due to antiepileptic drugs
6. Valproic acid, chemistry and biotransformation
7. Valproic acid induced neural tube defects in mouse and human: Aspects of chirality, alternative drug development, pharmacokinetics and possible mechanism
8. A comparative pharmacokinetic study of valpromide and valproic acid after intravenous administration in humans
9. Disposition of two tetramethylcyclopropane analogues of valpromide in the brain, liver, plasma and urine of rats
10. Pharmacokinetic analysis and antiepileptic activity of tetramethylcyclopropane analogues of valpromide
11. Effect of treatment with phenobarbital and stiripentol on carbamazepine-induced teratogenicity and reactive metabolite formation
12. Phenytoin-induced teratogenesis: A molecular basis for the observed developmental delay during neurulation
13. Teratogenicity of carbamazepine-10,11-epoxide and oxcarbamazepine in the SWV mouse
14. General principles: Experimental selection, quantification and evaluation of antiepileptic drugs
15. Comparative assay of antiepileptic drugs by "psychomotor" seizures and minimal electroshock threshold test
16. Pharmacological characterization of the 6-Hz psychomotor seizure model of partial epilepsy
17. Screening and characterization of antiepileptic drugs with rapidly recurring hippocampal seizures in rats
18. Modification of seizure activity by electrical stimulation, II: Motor seizure
19. General principles: Experimental selection, quantification and evaluation of antiepileptic drugs
20. The dihydropyridine nitredipine reduces N-methyl-D-aspartate (NMDA)-evoked currents of rodent cortical neurons through a direct interaction with NMDA receptor associated ion channel
21. Effects of the anticonvulsant Retigabine on cultured cortical neurons: Changes in electroresponsive properties and synaptic transmission
22. Improved patch clamp technique for high resolution current recording from cells and cell free membrane patches
23. Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite
24. Valproic acid-induced changes in gene expression during neurulation in a mouse model
25. The relation of mating, ovulation and the estrus smear in the house mouse to the time of day
26. Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate
27. 5-HT-mediated behavior: Animal studies
28. Kindling increases the sensitivity of rats to adverse effects of certain antiepileptic drugs
29. Pharmacology in the kindling model of epilepsy
30. Valproic acid induced neural tube defects in mouse and humans: Aspects of chirality, alternative drug development, pharmacokinetics and possible mechanism
31. Studies on the teratogen pharmacophore of valproic acid analogues: Evidence of interactions at a hydrophobic centre
32. Antiepileptic drug development program
33. Structure-pharmacokinetic relationships in a series of short fatty acid amides that possess anticonvulsant activity