Inhibition of HERG potassium channel current by the class 1a antiarrhythmic agent disopyramide

Biochemical and Biophysical Research Communications

Volumn 280, Issue 5, 2001, Pages 1243-1250

  Paul, Ashok A ^a   Witchel, Harry J ^a   Hancox, Jules C ^a  

^a SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

Author keywords

Antiarrhythmic; Cardiac; Delayed rectifier; Disopyramide; HERG; HERG S631A; IKr; Long QT syndrome; Potassium channel

Indexed keywords

ANTIARRHYTHMIC AGENT; COMPLEMENTARY DNA; DISOPYRAMIDE; GENE PRODUCT; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN HERG; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DOSE RESPONSE; HEART MUSCLE CELL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; QT INTERVAL; RABBIT;

CRICETINAE; CRICETULUS GRISEUS; ORYCTOLAGUS CUNICULUS;

EID: 0034810878     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4269     Document Type: Article

References (25)

1. Kr potassium channel
2. HERG, a human inward rectifier in the voltage-gated potassium channel family
3. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
4. Role of delayed rectifier potassium channels in cardiac repolarisation and arrhythmias
5. Familial and acquired long QT syndrome and the cardiac rapid delayed rectifier potassium current
6. QT interval prolongation by non-cardiovascular drugs: Issues and solutions for novel drug development
7. The potential for QT prolongation and pro-arrhythmia by non-antiarrhythmic drugs: Clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology
8. Antiarrhythmics - From cell to clinic: Past, present and future
9. The role of inactivation in open channel block of the sodium channel: Studies with inactivation-deficient mutant channels
10. Antiarrhythmic drugs and torsade de pointes
11. Early afterdepolarization-like activity in patients with class 1A induced long QT syndrome and torsades de pointes
12. Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans
13. + current. Differential sensitivity to block by Class III antiarrhythmic agents
14. Time course and voltage dependence of expressed HERG current compared with native 'rapid' delayed rectifier K current during the cardiac ventricular action potential
15. Alteration of HERG current profile during the cardiac ventricular action potential, following a pore mutation
16. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads
17. A method for isolating rabbit atrioventricular node myocytes which retain normal morphology and function
18. A method for making rapid changes of superfusate whilst maintaining temperature at 37°C
19. Use-dependent block of the delayed K current in rabbit ventricular myocytes
20. Effect of disopyramide on potassium currents in rabbit ventricular myocytes
21. Ks
22. Serum drug concentrations and adverse effects in cardiac patients after administration of a new controlled-release disopyramide preparation
23. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel
24. A mutation in the pore region of HERG K channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation
25. Comparative effects of three class I antiarrhythmic drugs on plateau and pacemaker currents of sheep cardiac Purkinje fibres