Determination of the substrate specificity of tripeptidyl-peptidase I using combinatorial peptide libraries and development of improved fluorogenic substrates

Journal of Biological Chemistry

Volumn 281, Issue 10, 2006, Pages 6559-6572

  Tian, Yu ^a   Sohar, Istvan ^a   Taylor, John W ^b   Lobel, Peter ^a,c,d  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d CABM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; ENZYMES; GENETIC ENGINEERING; MUTAGENESIS; NITROGEN COMPOUNDS; SUBSTRATES; SYNTHESIS (CHEMICAL);

FLUOROGENIC SUBSTRATES; GENE ENCODING; PEPTIDE LIBRARIES; SUBSTRATE SPECIFICITY;

ENZYME KINETICS;

7 AMINO 4 CARBAMOYLMETHYLCOUMARIN; COUMARIN DERIVATIVE; PENTAPEPTIDE; PEPTIDASE; PEPTIDE LIBRARY; TETRAPEPTIDE; TRIPEPTIDYL PEPTIDASE 1 ENZYME; UNCLASSIFIED DRUG; FLUORESCENT DYE; PROTEINASE; TRIPEPTIDYL PEPTIDASE I; TRIPEPTIDYL-PEPTIDASE I;

ARTICLE; COMBINATORIAL LIBRARY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME SPECIFICITY; ENZYME SYNTHESIS; FLUORESCENCE ANALYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; DRUG DESIGN; ENZYMOLOGY; HUMAN; KINETICS; METABOLISM; MOUSE; NEURONAL CEROID LIPOFUSCINOSIS; PH; SYNTHESIS; VALIDATION STUDY;

ANIMALS; DRUG DESIGN; ENDOPEPTIDASES; FLUORESCENT DYES; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MICE; NEURONAL CEROID-LIPOFUSCINOSES; PEPTIDE LIBRARY; SUBSTRATE SPECIFICITY;

EID: 33646582013     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M507336200     Document Type: Article

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