Acute monocytic leukemia with coexpression of minor BCR-ABL1 and PICALM-MLLT10 fusion genes along with overexpression of HOXA9

Genes Chromosomes and Cancer

Volumn 45, Issue 6, 2006, Pages 575-582

  Sindt, Audrey ^a   Deau, Benedicte ^b   Brahim, Wajih ^c   Staal, Anne ^d   Visanica, Sorin ^e   Villarese, Patrick ^b   Rault, Jean Philippe ^d   Macintyre, Elizabeth ^b,c   Delabesse, Eric ^b,c  

^a CHU NANCY BRABOIS   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d Centre Hospitalier Regional Metz Thionville   (France)

^e Bon Secours Hospital   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; BCR ABL PROTEIN; CYTARABINE; DAUNORUBICIN; HYBRID PROTEIN; PICALM MLLT10 FUSION PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ACUTE LYMPHOCYTIC LEUKEMIA; ACUTE MONOCYTIC LEUKEMIA; ADOLESCENT; ARTICLE; BCR ABLI GENE; CASE REPORT; CELL DIFFERENTIATION; CHROMOSOME TRANSLOCATION 9; CLINICAL PROTOCOL; DYSPNEA; ENZYME ACTIVATION; ENZYME ACTIVITY; FUSION GENE; GENE IDENTIFICATION; GENE MUTATION; GENE OVEREXPRESSION; HEADACHE; HOXA9 GENE; HUMAN; HUMAN CELL; MALE; ONCOGENE; PALLOR; PICALM MLLT10 GENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; BONE MARROW; FMS-LIKE TYROSINE KINASE 3; FOLLOW-UP STUDIES; FUSION PROTEINS, BCR-ABL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE FUSION; HOMEODOMAIN PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; LEUKEMIA, MONOCYTIC, ACUTE; MALE; METAPHASE; MODELS, GENETIC; MONOMERIC CLATHRIN ASSEMBLY PROTEINS; ONCOGENE PROTEINS, FUSION; PHENOTYPE; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 33646556154     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20320     Document Type: Article

References (52)

1. Abate-Shen C. 2002. Deregulated homeobox gene expression in cancer: cause or consequence? Nat Rev Cancer 2:777-785.
2. Ahuja HG, Popplewell L, Tcheurekdjian L, Slovak ML. 2001. NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia. Genes Chromosomes Cancer 30:410-415.
3. Alimena G, Cedrone M, Nanni M, De Cuia MR, Lo Coco F, De Sanctis V, Cimino G, Mancini M. 1995. Acute leukemia presenting a variant Ph chromosome with p190 expression, dup 3q and -7, developed after malignant lymphoma treated with alkylating agents and topoisomerase II inhibitors. Leukemia 9:1483-1486.
4. Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD, Sallan SE, Lander ES, Golub TR, Korsmeyer SJ. 2002. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 30:41-47.
5. Asnafi V, Radford-Weiss I, Dastugue N, Bayle C, Leboeuf D, Charrin C, Garand R, Lafage-Pochitaloff M, Delabesse E, Buzyn A, Troussard X, Macintyre E. 2003. CALM-AF10 is a common fusion transcript in T-ALL and is specific to the TCRgammadelta lineage. Blood 102:1000-1006.
6. Beillard E, Pallisgaard N, van der Velden VH, Bi W, Dee R, van der Schoot E, Delabesse E, Macintyre E, Gottardi E, Saglio G, Watzinger F, Lion T, van Dongen JJ, Hokland P, Gabert J. 2003. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR)-a Europe against Cancer program. Leukemia 17:2474-2486.
7. Borrow J, Shearman AM, Stanton VP, Jr., Becher R, Collins T, Williams AJ, Dube I, Katz F, Kwong YL, Morris C, Ohyashiki K, Toyama K, Rowley J, Housman DE. 1996. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nat Genet 12(2):159-167.
8. Brunning R, Matutes E, Flandrin G, Vardiman J, Bennett J, Head D, Harris N. 2001. Acute myeloid leukemia not otherwise categorised. In: Jaffe E, Harris N, Stein H, Vardiman J, editors. Tumours of haematopoietic and lymphoid tissues. Lyon, France: IARC Press, p 95-99.
9. Chaplin T, Ayton P, Bernard OA, Saha V, Della Valle V, Hillion J, Gregorini A, Lillington D, Berger R, Young BD. 1995a. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. Blood 85:1435-1441.
10. Chaplin T, Bernard O, Beverloo HB, Saha V, Hagemeijer A, Berger R, Young BD. 1995b. The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene. Blood 86:2073-2076.
11. Cortes J, Giles F, O'Brien S, Thomas D, Albitar M, Rios MB, Talpaz M, Garcia-Manero G, Faderl S, Letvak L, Salvado A, Kantarjian H. 2003. Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders. Cancer 97:2760-2766.
12. Damaj G, Delabesse E, Le Bihan C, Asnafi V, Rachid M, Lefrere F, Radford-Weiss I, Macintyre E, Hermine O, Varet B. 2002. Typical essential thrombocythaemia does not express bcr-abelson fusion transcript. Br J Haematol 116:812-816.
13. Dash AB, Williams IR, Kutok JL, Tomasson MH, Anastasiadou E, Lindahl K, Li S, Van Etten RA, Borrow J, Housman D, Druker B, Gilliland DG. 2002. A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc Natl Acad Sci USA 99:7622-7627.
14. Dastugue N, Duchayne E, Huguet F, Demur C, Plaisancie H, Calvas P, Bourrouillou G, Pris J, Colombies P. 1992. t(9;11)(p22;q23) translocation in blastic phase of chronic myeloid leukemia. Cancer Genet Cytogenet 63(1):37-42.
15. Dik WA, Brahim W, Braun C, Asnafi V, Dastugue N, Bernard OA, van Dongen JJ, Langerak AW, Macintyre EA, Delabesse E. 2005. CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes. Leukemia 19:1948-1957.
16. DiMartino JF, Ayton PM, Chen EH, Naftzger CC, Young BD, Cleary ML. 2002. The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood 99:3780-3785.
17. Dreyling MH, Martinez-Climent JA, Zheng M, Mao J, Rowley JD, Bohlander SK. 1996. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family. Proc Natl Acad Sci USA 93:4804-4809.
18. Dreyling MH, Schrader K, Fonatsch C, Schlegelberger B, Haase D, Schoch C, Ludwig W, Loffler H, Buchner T, Wormann B, Hiddemann W, Bohlander SK. 1998. MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis. Blood 91:4662-4667.
19. Ferrando AA, Armstrong SA, Neuberg DS, Sallan SE, Silverman LB, Korsmeyer SJ, Look AT. 2003. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 102:262-268.
20. Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N, Barbany G, Cazzaniga G, Cayuela JM, Cave H, Pane F, Aerts JL, De Micheli D, Thirion X, Pradel V, Gonzalez M, Viehmann S, Malec M, Saglio G, van Dongen JJ. 2003. Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia-a Europe Against Cancer program. Leukemia 17:2318-2357.
21. Gilliland DG. 2002. Molecular genetics of human leukemias: new insights into therapy. Semin Hematol 39(4 Suppl 3):6-11.
22. Ito K, Tominaga K, Suzuki T, Jinnai I, Bessho M. 2005. Successful treatment with imatinib mesylate in a case of minor BCR-ABL-positive acute myelogenous leukemia. Int J Hematol 81:242-245.
23. Kelly LM, Gilliland DG. 2002. Genetics of myeloid leukemias. Annu Rev Genomics Hum Genet 3:179-198.
24. Kelly LM, Kutok JL, Williams IR, Boulton CL, Amaral SM, Curley DP, Ley TJ, Gilliland DG. 2002. PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model. Proc Natl Acad Sci USA 99:8283-8288.
25. Kroon E, Krosl J, Thorsteinsdottir U, Baban S, Buchberg AM, Sauvageau G. 1998. Hoxa9 transforms primary bone marrow cells through specific collaboration with Meisla but not Pbx1b. Embo J 17:3714-3725.
26. Kurzrock R, Shtalrid M, Talpaz M, Kloetzer WS, Gutterman JU. 1987. Expression of c-abl in Philadelphia-positive acute myelogenous leukemia. Blood 70:1584-1588.
27. Li L, Ritterbach J, Harbott J, Schroyens W, Lohmeyer J, Pralle H, Lampert F. 1993. Elastic phase chronic myeloid leukemia with a four-break rearrangement: t(11;9)(9;22)(q23;p22q34;q11). Cancer Genet Cytogenet 68(2):131-134.
28. Libura M, Asnafi V, Tu A, Delabesse E, Tigaud I, Cymbalista F, Bennaceur-Griscelli A, Villarese P, Solbu G, Hagemeijer A, Beldjord K, Hermine O, Macintyre E. 2003. FLT3 and MLL intragenic abnormalities in AML reflect a common category of genotoxic stress. Blood 102:2198-2204.
29. Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P, Verrijzer CP, Saha V. 2000. Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation. J Mol Biol 299:369-378.
30. Melo JV, Myint H, Galton DA, Goldman JM. 1994. P190BCR-ABL chronic myeloid leukaemia: the missing link with chronic myelomonocytic leukaemia? Leukemia 8:208-211.
31. Najfeld V, Cuttner J, Figur A, Kawasaki ES, Witte ON, Clark SS. 1989. P185BCR-ABL in two patients with late appearing Philadelphia chromosome-positive acute nonlymphocytic leukemia. Leukemia 3:841-846.
32. Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen IM, Feinberg AP, Jenkins NA, Copeland NG, Shaughnessy JD Jr. 1996. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nat Genet 12(2):154-158.
33. Narita M, Shimizu K, Hayashi Y, Taki T, Taniwaki M, Hosoda F, Kobayashi H, Nakamura H, Sadamori N, Ohnishi H, Bessho F, Yanagisawa M, Ohki M. 1999. Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts. Br J Haematol 105:938-937.
34. Nishii K, Usui E, Sakakura M, Miyata E, Ridge SA, Ford AM, Masuya M, Chen F, Mitani H, Yamaguchi M, Katayama N, Kita K, Shiku H. 2001. Additional t(11;17)(q23;q21) in a patient with Philadelphia-positive mixed lineage antigen-expressing leukemia. Cancer Genet Cytogenet 126(1):8-12.
35. Noguera NI, Breccia M, Divona M, Diverio D, Costa V, De Santis S, Avvisati G, Pinazzi MB, Petti MC, Mandelli F, Lo Coco F, 2002. Alterations of the FLT3 gene in acute promyelocytic leukemia: association with diagnostic characteristics and analysis of clinical outcome in patients treated with the Italian AIDA protocol. Leukemia 16:2185-2189.
36. Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y. 2005. hDOT1L links histone methylation to leukemogenesis. Cell 121(2):167-178.
37. Paietta E, Racevskis J, Bennett JM, Neuberg D, Cassileth PA, Rowe JM, Wiernik PH. 1998. Biologic heterogeneity in Philadelphia chromosome-positive acute leukemia with myeloid morphology: the Eastern Cooperative Oncology Group experience. Leukemia 12:1881-1885.
38. Rabinowitz I, Larson R. 2004. Chronic myeloid leukemia. In: Greer J, Foerster J, Lukens J, Rodgers G, Paraskevas F, Glader B, editors. Wintrobe's clinical hematology. 11th ed. Philadelphia: Lippincott Williams & Wilkins. p 2235-2258.
39. Ren R. 2005. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer 5:172-183.
40. Rozovskaia T, Feinstein E, Mor O, Foa R, Blechman J, Nakamura T, Croce CM, Cimino G, Canaani E. 2001. Upregulation of Meis1 and HoxA9 in acute lymphocytic leukemias with the t(4:11) abnormality. Oncogene 20:874-878.
41. Rozovskaia T, Ravid-Amir O, Tillib S, Getz G, Feinstein E, Agrawal H, Nagler A, Rappaport EF, Issaeva I, Matsuo Y, Kees UR, Lapidot T, Lo Coco F, Foa R, Mazo A, Nakamura T, Croce CM, Cimino G, Domany E, Canaani E. 2003. Expression profiles of acute lymphoblastic and myeloblastic leukemias with ALL-1 rearrangements. Proc Natl Acad Sci USA 100:7853-7858.
42. Saha V, Chaplin T, Gregorini A, Ayton P, Young BD. 1995. The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins. Proc Natl Acad Sci USA 92:9737-9741.
43. Schessl C, Rawat VR Cusan M, Deshpande A, Kohl TM, Rosten PM, Spiekermann K, Humphries RK, Schnittger S, Kern W, Hiddemann W, Quintanilla-Martinez L, Bohlander SK, Feuring-Buske M, Buske C. 2005. The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice. J Clin Invest 115:2159-2168.
44. Schnittger S, Kohl TM, Haferlach T, Kern W, Hiddemann W, Spiekermann K, Schoch C. 2005. KIT-D816 mutations in AML1-ETO positive AML are associated with impaired event-free and overall survival. Blood.
45. Soulier J, Clappier E, Cayuela JM, Regnault A, Garcia-Pedro M, Dombret H, Baruchel A, Toribio ML, Sigaux F. 2005. HOXA genes are included in genetic and biological networks defining human acute T-cell leukemia (T-ALL). Blood 106(1):274-286.
46. Speleman F, Cauwelier B, Dastugue N, Cools J, Verhasselt B, Poppe B, Van Roy N, Vandesompele J, Graux C, Uyttebroeck A, Boogaerts M, De Moerloose B, Benoit Y, Selleslag D, Billiet J, Robert A, Huguet F, Vandenberghe P, De Paepe A, Marynen P, Hagemeijer A. 2005. A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. Leukemia 19:358-366.
47. Tebar F, Bohlander SK, Sorkin A. 1999. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic. Mol Biol Cell 10:2687-2702.
48. Thorsteinsdottir U, Mamo A, Kroon E, Jerome L, Bijl J, Lawrence HJ, Humphries K, Sauvageau G. 2002. Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Blood 99(1):121-129.
49. Wang YY, Zhou GB, Yin T, Chen B, Shi JY, Liang WX, Jin XL, You JH, Yang G, Shen ZX, Chen J, Xiong SM, Chen GQ, Xu F, Liu YW, Chen Z, Chen SJ. 2005. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci USA 102:1104-1109.
50. Wong S, Witte ON. 2004. The BCR-ABL story: bench to bedside and back. Annu Rev Immunol 22:247-306.
51. Yamamoto K, Nakamura Y, Saito K, Furusawa S. 2000. Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15). Br J Haematol 109:423-426.
52. Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L, Downing JR. 2002. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1(2):133-143.