Lowering of p27(Kip1) levels by its antisense or by development of resistance to 1,25-dihydroxyvitamin D3 reverses the G1 block but not differentiation of HL60 cells

Leukemia

Volumn 12, Issue 8, 1998, Pages 1256-1265

  Wang, Q M ^a   Chen, F ^a   Luo, X ^a   Moore, D C ^a   Flanagan, M ^b   Studzinski, G P ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b GILEAD SCIENCES   (United States)

Author keywords

1,25 dihydroxyvitamin D3; Antisense; Cell cycle; Differentiation; Leukemia cells

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CALCITRIOL; CYCLIN DEPENDENT KINASE INHIBITOR; PROTEIN P27; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; ENZYME INHIBITOR; MICROTUBULE ASSOCIATED PROTEIN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CONTROLLED STUDY; DNA TRANSFECTION; DRUG RESISTANCE; EXPRESSION VECTOR; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOSIS INHIBITION; PRIORITY JOURNAL; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; TIME; TUMOR SUPPRESSOR GENE;

CALCITRIOL; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; G1 PHASE; GENES, TUMOR SUPPRESSOR; HL-60 CELLS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; TIME FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0031596230     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2401088     Document Type: Article

References (14)

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