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Volumn 66, Issue 3-5, 2001, Pages 463-471

Highly active analogs of 1α,25-dihydroxyvitamin D3 that resist metabolism through C-24 oxidation and C-3 epimerization pathways

(10) Uskokovic, Milan R a Norman, Anthony W b Manchand, Percy S a Studzinski, George P c Campbell, Moray J d Koeffler, H Phillip e Takeuchi, Atsuko f Siu Caldera, Mei Ling g Rao, D Sunita g Reddy, G Satyanarayana g

a HOFFMANN LA ROCHE INC (United States)

b UNIVERSITY OF CALIFORNIA (United States)

c RUTGERS NEW JERSEY MEDICAL SCHOOL (United States)

d UNIVERSITY DEPARTMENT OF MEDICINE (United Kingdom)

e UNIVERSITY OF CALIFORNIA (United States)

f KOBE PHARMACEUTICAL UNIVERSITY (Japan)

g BROWN UNIVERSITY (United States)

Author keywords

1 ,25(OH)2D3; Analogs; C 24 oxidation pathway; C 3 Epimerization pathway; Metabolism; Metabolites

Indexed keywords

1ALPHA,25 DIHYDROXY 16 ENE 23 YNE 26,27 HEXAFLUORO 19 NOR VITAMIN D3; 1ALPHA,25 DIHYDROXY 16,23 DIENE 26,27 HEXAFLUORO 19 NOR VITAMIN D3; 1ALPHA,25 DIHYDROXY 3 EPI VITAMIN D3; ANTIMITOTIC AGENT; CALCITRIOL; CALCITRIOL DERIVATIVE; CALCITRIOL LACTONE; CALCITROIC ACID; CARBON; FLUORINE; HYDROGEN; HYDROXYL GROUP; RO 25 6760; RO 25 9022; RO 26 2198; SECOSTEROID; UNCLASSIFIED DRUG;

CHEMICAL BOND; CHEMICAL MODIFICATION; CONFERENCE PAPER; DRUG DESIGN; DRUG METABOLISM; DRUG SYNTHESIS; EPIMERIZATION; HUMAN; HYDROXYLATION; KIDNEY; LEUKEMIA CELL LINE; METABOLITE; MYELOID LEUKEMIA; NONHUMAN; OXIDATION;

ANIMALS; CALCITRIOL; HUMANS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; VITAMIN D;

EID: 0035342676 PISSN: 0039128X EISSN: None Source Type: Journal
DOI: 10.1016/S0039-128X(00)00226-9 Document Type: Conference Paper

Times cited : (54)

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