Identification of nuclear spliceosomal antigens targeted by NOD mouse antibodies following sodium iodide intake

Autoimmunity

Volumn 39, Issue 2, 2006, Pages 99-106

  Thompson, C ^a   Pomeranz Krummel, D A ^b   Jacobsen, H ^a   Nagai, K ^b   Cooke, A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Autoantibodies; NOD; Sj grens syndrome; Spliceosome

Indexed keywords

ANTINUCLEAR ANTIBODY; CELL NUCLEUS ANTIGEN; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B; IODINE; PROTEIN SM; SMALL NUCLEAR RIBONUCLEOPROTEIN; SODIUM IODIDE; SODIUM IODIDE SYMPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; EXPERIMENTAL MOUSE; FEMALE; HUMAN; HUMAN CELL; IMMUNOASSAY; MALE; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SALIVARY GLAND; SPLICEOSOME; THYROID GLAND;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, ANTINUCLEAR; ANTIBODY SPECIFICITY; AUTOANTIGENS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED NOD; MOLECULAR SEQUENCE DATA; RIBONUCLEOPROTEIN, U1 SMALL NUCLEAR; RIBONUCLEOPROTEINS, SMALL NUCLEAR; RNA-BINDING PROTEINS; SJOGREN'S SYNDROME; SODIUM IODIDE; SPLICEOSOMES;

EID: 33646399183     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930600597276     Document Type: Article

References (47)

1. Casiano, CA and Tan, EM. (1996) Recent developments in the understanding of antinuclear autoantibodies Int Arch Allergy Immunol, 111, pp. 308-313.
2. Routsias, JG and Tzioufas, AG and Moutsopoulos, HM. (2004) The clinical value of intracellular autoantigens B-cell epitopes in systemic rheumatic diseases Clin Chim Acta, 340, pp. 1-25.
3. Mavragani, CP and Tzioufas, AG and Moutsopoulos, HM. (2000) Sjogren's syndrome: Autoantibodies to cellular antigens Clin Mol Aspects Int Arch Allergy Immunol, 123, pp. 46-57.
4. Humphreys-Beher, MG and Yamachika, S and Yamamoto, H and Maeda, N and Nakagawa, Y and Peck, AB and Robinson, CP. (1998) Salivary gland changes in the NOD mouse model for Sjogren's syndrome: Is there a non-immune genetic trigger? Eur J Morphol, 36 (Suppl), pp. 247-251.
5. Skarstein, K and Wahren, M and Zaura, E and Hattori, M and Jonsson, R. (1995) Characterization of T cell receptor repertoire and anti-Ro/SSA autoantibodies in relation to sialadenitis of NOD mice Autoimmunity, 22, pp. 9-16.
6. Baxter, AG and Horsfall, AC and Healey, D and Ozegbe, P and Day, S and Williams, DG and Cooke, A. (1994) Mycobacteria precipitate an SLE-like syndrome in diabetes-prone NOD mice Immunology, 83, pp. 227-231.
7. Dohan, O and De la Vieja, A and Paroder, V and Riede, LC and Artani, M and Reed, M and Ginter, CS and Carrasco, N. (2003) The sodium/iodide symporter (NIS): Characterization, regulation, and medical significance Endocr Rev, 24, pp. 48-77.
8. De La Vieja, A and Dohan, O and Levy, O and Carrasco, N. (2000) Molecular analysis of the sodium/iodide symporter: Impact on thyroid and extrathyroid pathophysiology Physiol Rev, 80, pp. 1083-1105.
9. Spitzweg, C and Joba, W and Schriever, K and Goellner, JR and Morris, JC and Heufelder, AE. (1999) Analysis of human sodium iodide symporter immunoreactivity in human exocrine glands J Clin Endocrinol Metab, 84, pp. 4178-4184.
10. Hutchings, PR and Verma, S and Phillips, JM and Harach, SZ and Howlett, S and Cooke, A. (1999) Both CD4(+) T cells and CD8(+) T cells are required for iodine accelerated thyroiditis in NOD mice Cell Immunol, 192, pp. 113-121.
11. Rose, NR and Rasooly, L and Saboori, AM and Burek, CL. (1999) Linking iodine with autoimmune thyroiditis Environ Health Perspect, 107(Suppl 5), pp. 749-752.
12. Rasooly, L and Burek, CL and Rose, NR. (1996) Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice Clin Immunol Immunopathol, 81, pp. 287-292.
13. Kambach, C and Walke, S and Nagai, K. (1999) Structure and assembly of the spliceosomal small nuclear ribonucleoprotein particles Curr Opin Struct Biol, 9, pp. 222-230.
14. Rosen, A and Casciola-Rosen, L. (1999) Autoantigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease Cell Death Differ, 6, pp. 6-12.
15. Scherly, D and Boelens, W and Dathan, NA and Kambach, C and van Venrooij, WJ and Mattaj, IW. (1990) Binding specificity determinants of U1A and U2B″ proteins Mol Biol Rep, 14, pp. 181-182.
16. Jaekel, HP and Klopsch, T and Benkenstein, B and Grobe, N and Baldauf, A and Schoessler, W and Werle, E. (2001) Reactivities to the Sm autoantigenic complex and the synthetic SmD1-aa83-119 peptide in systemic lupus erythematosus and other autoimmune diseases J Autoimmun, 17, pp. 347-354.
17. McClain, MT and Ramsland, PA and Kaufman, KM and James, JA. (2002) Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens J Immunol, 168, pp. 2054-2062.
18. Kambach, C and Walke, S and Young, R and Avis, JM and de la Fortelle, E and Raker, VA and Luhrmann, R and Li, J and Nagai, K. (1999) Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs Cell, 96, pp. 375-387.
19. Field, M and Williams, DG and Charles, P and Maini, RN. (1988) Specificity of anti-Sm antibodies by ELISA for systemic lupus erythematosus: Increased sensitivity of detection using purified peptide antigens Ann Rheum Dis, 47, pp. 820-825.
20. Weatherall, D and Sarvetnick, N and Shizuru, JA. (1992) Genetic control of diabetes mellitus Diabetologia, 35(Suppl 2), pp. S1-S7.
21. Lerner, EA and Lerner, MR and Janeway, CA, Jr and Steitz, JA. (1981) Monoclonal antibodies to nucleic acid-containing cellular constituents: Probes for molecular biology and autoimmune disease Proc Natl Acad Sci USA, 78, pp. 2737-2741.
22. Sleeman, JE and Lamond, AI. (1999) Nuclear organization of pre-mRNA splicing factors Curr Opin Cell Biol, 11, pp. 372-377.
23. Sleeman, JE and Lamond, AI. (1999) Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway Curr Biol, 9, pp. 1065-1074.
24. Martin, RM and Silva, A and Lew, AM. (1997) The Igh-1 sequence of the non-obese diabetic (NOD) mouse assigns it to the IgG2c isotype Immunogenetics, 46, pp. 167-168.
25. Martin, RM and Brady, JL and Lew, AM. (1998) The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice J Immunol Methods, 212, pp. 187-192.
26. Makino, S and Kunimoto, K and Muraoka, Y and Mizushima, Y and Katagiri, K and Tochino, Y. (1980) Breeding of a non-obese, diabetic strain of mice Jikken Dobutsu, 29, pp. 1-13.
27. Perez, B and Kraus, A and Lopez, G and Cifuentes, M and Alarcon-Segovia, D. (1995) Autoimmune thyroid disease in primary Sjogren's syndrome Am J Med, 99, pp. 480-484.
28. Binder, A and Maddison, PJ and Skinner, P and Kurtz, A and Isenberg, DA. (1989) Sjogren's syndrome: Association with type-1 diabetes mellitus Br J Rheumatol, 28, pp. 518-520.
29. Ban, Y and Tomer, Y. (2005) Susceptibility genes in thyroid autoimmunity Clin Dev Immunol, 12, pp. 47-58.
30. Rose, NR and Bonita, R and Burek, CL. (2002) Iodine: An environmental trigger of thyroiditis Autoimmun Rev, 1, pp. 97-103.
31. Casiano, CA and Tan, EM. (1996) Antinuclear autoantibodies: Probes for defining proteolytic events associated with apoptosis Mol Biol Rep, 23, pp. 211-216.
32. Casiano, CA and Ochs, RL and Tan, EM. (1998) Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes Cell Death Differ, 5, pp. 183-190.
33. Gordon, TP and Kinoshita, G and Cavill, D and Keech, C and Farris, A and Kaufman, K and McCluskey, J and Purcell, A. (2002) Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDa Ro (SS-A) in experimental autoimmunity Scand J Immunol, 56, pp. 168-173.
34. Itoh, Y and Itoh, K and Frank, MB and Reichlin, M. (1992) Autoantibodies to the Ro/SSA autoantigen are conformation dependent. II: Antibodies to the denatured form of 52 kD Ro/SSA are a cross reacting subset of antibodies to the native 60 kD Ro/SSA molecule Autoimmunity, 14, pp. 89-95.
35. Itoh, Y and Reichlin, M. (1992) Autoantibodies to the Ro/SSA antigen are conformation dependent. I: Anti-60 kD antibodies are mainly directed to the native protein; anti-52 kD antibodies are mainly directed to the denatured protein Autoimmunity, 14, pp. 57-65.
36. Malmegrim, KC and Pruijn, GJ and van Venrooij, WJ. (2002) The fate of the U1 snRNP autoantigen during apoptosis: Implications for systemic autoimmunity Isr Med Assoc J, 4, pp. 706-712.
37. Monneaux, F and Dumortier, H and Steiner, G and Briand, JP and Muller, S. (2001) Murine models of systemic lupus erythematosus: B and T cell responses to spliceosomal ribonucleoproteins in MRL/Fas(lpr) and (NZB × NZW)F(1) lupus mice Int Immunol, 13, pp. 1155-1163.
38. Degen, WG and Aarssen, Y and Pruijn, GJ and Utz, PJ and van Venrooij, WJ. (2000) The fate of U1 snRNP during anti-Fas induced apoptosis: Specific cleavage of the U1 snRNA molecule Cell Death Differ, 7, pp. 70-79.
39. Monneaux, F and Lozano, JM and Patarroyo, ME and Briand, JP and Muller, S. (2003) T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MR/lpr mice Eur J Immunol, 33, pp. 287-296.
40. Monneaux, F and Muller, S. (2002) Epitope spreading in systemic lupus erythematosus: Identification of triggering peptide sequences Arthritis Rheum, 46, pp. 1430-1438.
41. Leijon, K and Hammarstrom, B and Holmberg, D. (1994) Non-obese diabetic (NOD) mice display enhanced immune responses and prolonged survival of lymphoid cells Int Immunol, 6, pp. 339-345.
42. O'Brien, BA and Huang, Y and Geng, X and Dutz, JP and Finegood, DT. (2002) Phagocytosis of apoptotic cells by macrophages from NOD mice is reduced Diabetes, 51, pp. 2481-2488.
43. Leadbetter, EA and Rifkin, IR and Hohlbaum, AM and Beaudette, BC and Shlomchik, MJ and Marshak-Rothstein, A. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and toll-like receptors Nature, 416, pp. 603-607.
44. Viglianti, GA and Lau, CM and Hanley, TM and Miko, BA and Shlomchik, MJ and Marshak-Rothstein, A. (2003) Activation of autoreactive B cells by CpG dsDNA Immunity, 19, pp. 837-847.
45. Muto, Y and Pomeranz Krummel, D and Oubridge, C and Hernandez, H and Robinson, CV and Neuhaus, D and Nagai, K. (2004) The structure and biochemical properties of the human spliceosomal protein U1C J Mol Biol, 341, pp. 185-198.
46. Jurica, MS and Moore, MJ. (2003) Pre-mRNA splicing: Awash in a sea of proteins Mol Cell, 12, pp. 5-14.
47. Price, SR and Evans, PR and Nagai, K. (1998) Crystal structure of the spliceosomal U2B″ U2A′ protein complex bound to a fragment of U2 small nuclear RNA Nature, 394, pp. 645-650.