KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier

Journal of Physiology

Volumn 573, Issue 1, 2006, Pages 17-34

  Schwarz, J R ^a   Glassmeier, G ^a   Cooper, E C ^b   Kao, T C ^b   Nodera, H ^c   Tabuena, D ^c   Kaji, R ^c   Bostock, H ^d  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

10,10 BIS(4 PYRIDINYLMETHYL) 9(10H) ANTHRACENONE; LINOPIRDINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KCNQ2; POTASSIUM CHANNEL KCNQ3; RETIGABINE; UNCLASSIFIED DRUG; MONOCLONAL ANTIBODY; POTASSIUM; POTASSIUM CHLORIDE; TETRYLAMMONIUM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; IC 50; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; IN VIVO STUDY; INHIBITION KINETICS; MALE; MEMBRANE POTENTIAL; MOTOR NERVE; MUSCLE ACTION POTENTIAL; MYELINATED NERVE; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE EXCITABILITY; NERVE STIMULATION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RANVIER NODE; RAT; SCIATIC NERVE; VOLTAGE CLAMP; ADULT; ANIMAL CELL; ANIMAL TISSUE; CHANNEL GATING; HETEROLOGOUS EXPRESSION; IMMUNOFLUORESCENCE MICROSCOPY; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE POTENTIAL; STIMULUS RESPONSE; VOLTAGE CLAMP TECHNIQUE;

ACTION POTENTIALS; ANIMALS; ANTHRACENES; ANTIBODIES; IMMUNOHISTOCHEMISTRY; KCNQ2 POTASSIUM CHANNEL; KCNQ3 POTASSIUM CHANNEL; MALE; MOTOR NEURONS; NERVE FIBERS, MYELINATED; PATCH-CLAMP TECHNIQUES; POTASSIUM; RABBITS; RANVIER'S NODES; RATS; RATS, WISTAR; SCIATIC NERVE;

EID: 33646378890     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.106815     Document Type: Article

References (54)

1. Baker M & Bostock H (1989). Depolarization changes the mechanism of accommodation in rat and human motor axons. J Physiol 411, 545-561.
2. Baker M, Bostock H, Grafe P & Martius P (1987). Function and distribution of three types of rectifying channel in rat spinal root myelinated axons. J Physiol 383, 45-67.
3. Bergmann C, Nonner W & Stämpfli R (1968). Sustained spontaneous activity of Ranvier nodes induced by the combined action of TEA and lack of calcium. Pflugers Arch 302, 24-37.
4. Bergmans J (1970). The Physiology of Single Human Nerve Fibres. University of Louvain, Vander, Belgium.
5. Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ & Steinlein OK (1998). A potassium channel mutation in neonatal human epilepsy. Science 279, 403-406.
6. Bostock H (1995). Mechanisms of accommodation and adaptation in myelinated axons. In The Axon, ed. Waxman SG, Stys PK & Kocsis JD, pp. 311-327. Oxford University Press, Oxford.
7. Bostock H & Baker M (1988). Evidence for two types of potassium channel in human motor axons in vivo. Brain Res 462, 354-358.
8. Bostock H, Burke D & Hales JP (1994). Differences in behaviour of sensory and motor axons following release of ischaemia. Brain 117, 225-234.
9. Bostock H, Cikurel K & Burke D (1998). Threshold tracking techniques in the study of human peripheral nerve. Muscle Nerve 21, 137-158.
10. Bostock H & Rothwell JC (1997). Latent addition in motor and sensory fibres of human peripheral nerve. J Physiol 498, 277-294.
11. Brismar T (1980). Potential clamp analysis of membrane currents in rat myelinated nerve fibres. J Physiol 298, 171-184.
12. Brown DA (1988). M currents. In Ion Channels 1, ed. Narahashi T, pp. 55-94. Plenum Press, New York & London.
13. Burke D, Kiernan MC & Bostock H (2001). Excitability of human axons. Clin Neurophysiol 112, 1575-1585.
14. Cooper EC, Harrington E, Jan YN & Jan LY (2001). M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci 21, 9529-9540.
15. + channel. PNAS 98, 12272-12277.
16. Delmas P & Brown DA (2005). Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat Rev Neurosci 6, 850-862.
17. + channel. J Neurosci 24, 1236-1244.
18. Dubois JM (1981). Evidence for the existence of three types of potassium channels in the frog Ranvier node membrane. J Physiol 318, 297-316.
19. Dubois JM (1983). Potassium currents in the frog node of Ranvier. Prog Biophys Mol Biol 42, 1-20.
20. Gokin AP, Philip B & Strichartz GR (2001). Preferential block of small myelinated sensory and motor fibres by lidocaine: In vivo electrophysiology in the rat sciatic nerve. Anesthesiology 95, 1441-1454.
21. Hadley JK, Noda M, Selyanko AA, Wood IC, Abogadie FC & Brown DA (2000). Differential tetraethylammonium sensitivity of KCNQ1-4 potassium channels. Br J Pharmacol 129, 413-415.
22. Hadley JK, Passmore GM, Tatulian L, Al-Qatari M, Ye F, Wickenden AD & Brown DA (2003). Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium. J Neurosci 23, 5012-5019.
23. Jentsch TJ (2000). Neuronal KCNQ potassium channels: Physiology and disease. Nature Rev Neurosci 1, 21-30.
24. Kiernan MC, Burke D, Andersen KV & Bostock H (2000). Multiple measures of axonal excitability: A new approach in clinical testing. Muscle Nerve 23, 399-409.
25. Kiernan MC, Hart IK & Bostock H (2001). Excitability properties of motor axons in patients with spontaneous motor unit activity. J Neurol Neurosurg Psychiatry 70, 56-64.
26. K (M)) and some other voltage- and ligand-gated membrane currents in rat sympathetic neurons. Europ J Neurosci 9, 605-616.
27. Neumcke B, Schwarz JR & Stämpfli R (1987). A comparison of sodium currents in rat and frog myelinated nerve: Normal and modified sodium inactivation. J Physiol 382, 175-191.
28. Neumcke B & Stämpfli R (1982). Sodium currents and sodium-current fluctuations in rat myelinated nerve fibres. J Physiol 329, 163-184.
29. Nonner W (1969). A new voltage clamp method for Ranvier nodes. Pflugers Arch 309, 176-192.
30. Pan Z, Selyanko AA, Hadley JK, Brown DA, Dixon JE & McKinnon D (2001). Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents. J Physiol 531, 347-358.
31. Passmore GM, Selyanko AA, Mistry M, Al-Qatari M, Marsh SS, Matthews EA, Dickenson AH, Brown TA, Burbidge SA, Main M & Brown DA (2003). KCNQ/ M currents in sensory neurons: Significance for pain therapy. J Neurosc 23, 7227-7236.
32. Poliak S & Peles E (2003). The local differentiation of myelinated axons at nodes of Ranvier. Nature Rev Neurosci 4, 968-980.
33. Rasband MN, Trimmer JS, Schwarz TL, Levinson SR, Ellisman MH, Schachner M & Shrager P (1998). Potassium channel distribution, clustering, and function in remyelinating rat axons. J Neurosci 18, 36-47.
34. Reid G, Bostock H & Schwarz JR (1993). Quantitative description of action potentials and membrane currents in human node of Ranvier. J Physiol 467, 247 P.
35. Reid G, Scholz A, Bostock H & Vogel W (1999). Human axons contain at least five types of voltage-dependent potassium channels. J Physiol 518, 681-696.
36. Röper J & Schwarz JR (1989). Heterogeneous distribution of fast and slow potassium channels in myelinated rat nerve fibres. J Physiol 416, 93-110.
37. + channels in neuronal cells. Europ J Pharmacol 336, 243-249.
38. Rundfeldt C & Netzer R (2000). The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits. Neurosci Lett 282, 73-76.
39. Safronov BV, Kampe K & Vogel W (1993). Single voltage-dependent potassium channels in rat peripheral nerve membrane. J Physiol 460, 675-691.
40. Scherer SS, Arroyo EJ & Peles E (2004). Functional organization of the nodes of Ranvier. In Myelin Biology and Disorders, ed. Lazzarini RA, Griffin JW, Lassman H, Nave K-A, Miller R & Trapp B, pp. 89-116. Elsevier, San Diego.
41. Schmalbruch H (1986). Fiber composition of the rat sciatic nerve. Anat Rec 215, 71-81.
42. Schroeder BC, Kubisch C, Stein V & Jentsch TJ (1998). Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K channels causes epilepsy. Nature 396, 687-690.
43. Schwarz JR, Reid G & Bostock H (1995). Action potentials and membrane currents in the human node of Ranvier. Pflugers Arch 430, 283-292.
44. Selyanko AA, Hadley JK & Brown DA (2001). Properties of single M-type KCNQ2/KCNQ3 potassium channels expressed in mammalian cells. J Physiol 534, 15-24.
45. Selyanko AA, Hadley JK, Wood IC, Abogadie FC, Jentsch TJ & Brown DA (2000). Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors. J Physiol 522, 349-355.
46. Shen W, Hamilton SE, Nathanson NM & Surmeier DJ (2005). Cholinergic suppression of KCNQ channel currents enhances excitability of striatal medium spiny neurons. J Neurosc 25, 7449-7458.
47. Singh NA, Charlier C, Stauffer D, DuPont BR, Leach RJ, Melis R, Ronen GM, Bjerre I, Quattlebaum T & Murphy JV (1998). A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet 18, 25-29.
48. Stämpfli R & Hille B (1976). Electrophysiology of the peripheral myelinated nerve. In Frog Neurobiology, ed. Llinás R & Precht W, pp. 3-32. Springer Verlag, Berlin Heidelberg.
49. Tatulian L, Delmas P, Abogadie FC & Brown DA (2001). Activation of expressed KCNQ potassium currents and native neuronal M-type potassium currents by the anti-convulsant drug retigabine. J Neurosci 21, 5535-5545.
50. Vleggeert-Lankamp CL, Van den Berg RJ, Feirabend HK, Lakke EA, Malessy MJ & Thomeer RT (2004). Electrophysiology and morphometry of the Aα- and Aβ-fiber populations in the normal and regenerating rat sciatic nerve. Exp Neurol 187, 337-349.
51. Vogel W & Schwarz JR (1995). Voltage-clamp studies in axons: macroscopic and single-channel currents. Action potentials and nodal membrane currents. In The Axon, ed. Waxman JD, Kocsis JD & Stys PK, pp. 257-280. Oxford University Press, Oxford.
52. Wang H-S, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE & McKinnon D (1998). KCNQ2 and KCNQ3 potassium channel subunits: Molecular correlates of the M-channel. Science 282, 1890-1893.
53. Wickenden AD, Yu W, Zou A, Jegla T & Wagoner PK (2000). Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol Pharmacol 58, 591-600.
54. Yang Q, Kaji R, Hirota N, Kojima Y, Takagi T, Kohara N, Kimura J, Shibasaki H & Bostock H (2000). Effect of maturation on nerve excitability in an experimental model of threshold electrotonus. Muscle Nerve 23, 498-506.