CD40 deficiency mitigates Alzheimer's disease pathology in transgenic mouse models

Journal of Neuroinflammation

Volumn 3, Issue , 2006, Pages

  Laporte, Vincent ^a   Ait Ghezala, Ghania ^a   Volmar, Claude Henry ^a   Mullan, Michael ^a  

^a ROSKAMP INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CD40 LIGAND; CD45 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; PRESENILIN 1;

ALZHEIMER DISEASE; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN REGION; COMPARATIVE STUDY; CONTROLLED STUDY; GENE DISRUPTION; GLIOSIS; MICROGLIA; MOUSE; NEUROPATHOLOGY; NONHUMAN; PROTEIN ANALYSIS; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

EID: 33646261886     PISSN: 17422094     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-3-3     Document Type: Article

References (18)

1. Selkoe DJ: Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001, 81(2):741-766.
2. Meda L, Cassatella MA, Szendrei GI, Otvos LJ, Baron P, Villalba M, Ferrari D, Rossi F: Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 1995, 374(6523):647-650.
3. Tan J, Town T, Paris D, Mori T, Suo Z, Crawford F, Mattson MP, Flavell RA, Mullan M: Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science 1999, 286(5448):2352-2355.
4. Calingasan NY, Erdely HA, Altar CA: Identification of CD40 ligand in Alzheimers disease and in animal models of Alzheimer's disease and brain injury. Neurobiol Aging 2002, 23(1):31-39.
5. Togo T, Akiyama H, Kondo H, Ikeda K, Kato M, Iseki E, Kosaka K: Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases. Brain Res 2000, 885(1):117-121.
6. Ait-Ghezala G, Mathura VS, Laporte V, Quadros A, Paris D, Patel N, Volmar CH, Kolippakkam D, Crawford F, Mullan M: Genomic regulation after CD40 stimulation in microglia: Relevance to Alzheimer's disease. Brain Res Mol Brain Res 2005.
7. Tan J, Town T, Crawford F, Mori T, DelleDonne A, Crescentini R, Obregon D, Flavell RA, Mullan MJ: Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice. Nat Neurosci 2002, 5(12):1288-1293.
8. Todd Roach J, Volmar CH, Dwivedi S, Town T, Crescentini R, Crawford F, Tan J, Mullan M: Behavioral effects of CD40-CD40L pathway disruption in aged PSAPP mice. Brain Res 2004, 1015(12):161-168.
9. Kawabe T, Naka T, Yoshida K, Tanaka T, Fujiwara H, Suematsu S, Yoshida N, Kishimoto T, Kikutani H: The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1994, 1(3):167-178.
10. Hsiao K: Transgenic mice expressing Alzheimer amyloid precursor proteins. Exp Gerontol 1998, 33(7-8):883-889.
11. Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, Eckman C, Younkin S, Hsiao K, Duff K: Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin I transgenes. Nat Med 1998, 4(1):97-100.
12. Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG: Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 2001, 21(2):372-381.
13. Noda-Saita K, Terai K, Iwai A, Tsukamoto M, Shitaka Y, Kawabata S, Okada M, Yamaguchi T: Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer's disease. Acta Neuropathol (Berl) 2004, 108(5):435-442.
14. Tan J, Town T, Mori T, Obregon D, Wu Y, DelleDonne A, Rojiani A, Crawford F, Flavell RA, Mullan M: CD40 is expressed and functional on neuronal cells. Embo J 2002, 21(4):643-652.
15. Dong Y, Benveniste EN: Immune function of astrocytes. Glia 2001, 36(2):180-190.
16. Abdel-Haq N, Hao HN, Lyman WD: Cytokine regulation of CD40 expression in fetal human astrocyte cultures. J Neuroimmunol 1999, 101(1):7-14.
17. Liao YF, Wang BJ, Cheng HT, Kuo LH, Wolfe MS: Tumor necrosis factor-alpha, interleukin-I beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J Biol Chem 2004, 279(47):49523-49532.
18. Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN: Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-I through 5'-untranslated region sequences. J Biol Chem 1999, 274(10):6421-6431.