Linear and nonlinear QSAR study of N-hydroxy-2-[(phenylsulfonyl)amino]acetamide derivatives as matrix metalloproteinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 12, 2006, Pages 4137-4150

  Fernández, Michael ^a   Caballero, Julio ^a   Tundidor Camba, Alain ^b  

^a UNIVERSITY OF MATANZAS   (Cuba)

^b NATL CENTER FOR SCIENTIFIC RESEARCH   (Cuba)

Author keywords

2D Autocorrelation space; Bayesian regularized Genetic Neural Networks; MMP inhibitors; QSAR analysis

Indexed keywords

ACETAMIDE DERIVATIVE; COLLAGENASE 3; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE INHIBITOR; STROMELYSIN;

ARTICLE; ARTIFICIAL NEURAL NETWORK; BAYES THEOREM; CORRELATION ANALYSIS; ENZYME INHIBITION; GENETIC ALGORITHM; IC 50; MATHEMATICAL MODEL; MULTIPLE LINEAR REGRESSION ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS;

ACETAMIDES; ALGORITHMS; ENZYME INHIBITORS; LINEAR MODELS; MATRIX METALLOPROTEINASES; MODELS, GENETIC; MOLECULAR STRUCTURE; NEURAL NETWORKS (COMPUTER); QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REGRESSION ANALYSIS; STEREOISOMERISM; SULFONAMIDES;

EID: 33646186011     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.072     Document Type: Article

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