Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice

Toxicology Letters

Volumn 164, Issue 1, 2006, Pages 44-53

  Sun, Guobin ^a   Thai, Sheau Fung ^a   Lambert, Guy R ^a   Wolf, Douglas C ^a   Tully, Douglas B ^a   Goetz, Amber K ^a   George, Michael H ^a   Grindstaff, Rachel D ^a   Dix, David J ^a   Nesnow, Stephen ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Alkoxyresorufin O dealkylation; Cyp; Fluconazole; P450; PCR; Western

Indexed keywords

ANTIFUNGAL AGENT; BENZYLOXYRESORUFIN DEALKYLASE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; CYTOCHROME P450 3A23; ETHOXYRESORUFIN DEETHYLASE; FLUCONAZOLE; MESSENGER RNA; MICROSOME ENZYME; PENTOXYRESORUFIN DEALKYLASE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEALKYLATION; DOSE RESPONSE; ENZYME ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; LIVER; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTIFUNGAL AGENTS; BLOTTING, WESTERN; CYTOCHROME P-450 ENZYME SYSTEM; FLUCONAZOLE; GENE EXPRESSION; LIVER; MALE; MICE; MICE, INBRED STRAINS; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

ANIMALIA;

EID: 33646114052     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.11.015     Document Type: Article

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