Climbazole is a new potent inducer of rat hepatic cytochrome P450

Journal of Toxicological Sciences

Volumn 26, Issue 3, 2001, Pages 141-150

  Kobayashi, Yasuna ^a   Suzuki, Michiya ^a   Ohshiro, Naomi ^a   Sunagawa, Takashi ^a   Sasaki, Tadanori ^a   Tokuyama, Shogo ^a   Yamamoto, Toshinori ^a   Yoshida, Takemi ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Climbazole; Cytochrome P450; Enzyme induction; Imidazole

Indexed keywords

7 ETHOXYCOUMARIN DEETHYLASE; AMINOPHENAZONE; ANDROSTENEDIONE DERIVATIVE; BIFONAZOLE; CIMETIDINE; CLIMBAZOLE; CLORIMAZOLE; CLOTRIMAZOLE; CYTOCHROME P450 3A2; CYTOCHROME P450 4A1; CYTOCHROME P450 ISOENZYME; DRUG METABOLIZING ENZYME; ECONAZOLE; IMIDAZOLE DERIVATIVE; KETOCONAZOLE; MICONAZOLE; N DEMETHYLASE; PENTOXYRESORUFIN DEALKYLASE; PYRROLE DERIVATIVE; SULCONAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ENZYME INDUCTION; FEMALE; LIVER MICROSOME; MALE; NONHUMAN; RAT;

ANIMALIA;

EID: 0034872438     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.26.141     Document Type: Article

References (38)

1. 1-Benzylimidazole induces rat hepatic microsomal epoxide hydrolase with the elevation of its mRNA levels
2. Drug-metabolizing enzyme induction by simple diaryl pyridines; 2-substituted isomers selectively increase only conjugation enzyme activities, 4-substituted isomers also induce cytochrome P450
3. Whether cytochrome P450 induction accompanies glucuronosyl and glutathione transferase induction by isomers of dipyridyl appears unrelated to dose and iron chelation properties
4. Concomitant induction of microsomal epoxide hydrolase and UDP-glucuronosyltransferase activities by dipyridine compounds
5. Cytochrome P450 in rodents
6. Statistics for toxicologist
7. The molecular biology of cytochrome P450s
8. Evidence for functional and structural multiplicity of pregnenolone-16 α-carbonitrileinducible cytochrome P-450 isozymes in rat liver microsomes
9. Catalytic selectively and mechanismbased inactivation of stably expressed and hepatic cytochrome P450 2B4 and 2B5: Implications of the cytochrome P450 2B5 polymorphism
10. Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: Substrate specificity and inhibitor selectively studies
11. Coinduction of multiple hepatic cytochrome P-450 protein and their mRNAs in rats treated with imidazole antimycotic agents
12. Acute and subacute effects of miconazole nitrate on hepatic styrene oxide hydrolase and cytochrome P-450-dependent monooxygenase activities in male and female AKR/J mice
13. Clotrimazole as an inhibitor of benzo[α]pyrene metabolite-DNA adduct formation in vitro and of microsomal monooxygenase activity
14. The induction of cytochrome P4502E1 by nitrogen- and sulfur-containing heterocycles: Expression and molecular regulation
15. Induction of hepatic microsomal cytochrome P450 and drug-metabolizing enzymes by 4-benzylpyridine and its structurally related compounds in rats: Dose- and sexrelated differential induction of cytochrome P450 species
16. Structural requirements for the induction of hepatic microsomal cytochrome P450 by imidazole- and pyridine-containing compounds in rats
17. Involvement of testosterone in the induction of hepatic microsomal cytochrome P-450 2B1/2 (P-450 2B 1/2) by 1-benzylimidazole in male and female rats: Sex-differentiated induction of P-450 2B 1/2 species
18. Induction of hepatic microsomal P450 by 4-phenylalkylpyridines in rat; chain length-dependent and sex-related differential induction of P450s
19. Differential induction of hepatic and renal microsomal cytochrome P450 by N-phenylalkylimidazoles in rats
20. Regio-related differential induction of hepatic microsomal heme oxygenase and cytochrome P450 by substituted imidazole and pyridine compounds in rats
21. Concurrent induction of rat hepatic microsomal cytochrome P450 and heme oxygenase by 2,2′-dipyridyl ketone: Comparison with the effect of 2,2′-dipyridyl amine
22. Effect of 4-(4-chlorobenzyl)pyridine on rat hepatic microsomal cytochrome P450 and drug-metabolizing enzymes in vivo and in vitro
23. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
24. Induction and inhibition of rat liver cytochrome(s) P-450 by an imidazole fungicide (prochloraz)
25. Induction potential of antifungals containing an imidazole or triazole moiety
26. Protein measurement with the Folin phenol reagent
27. Structureactivity relationships in the induction of hepatic microsomal cytochrome P450 by clotrimazole and its structurally related compounds in rats
28. Analogues of chloramphenicol as mechanism-based inactivators of rat liver cytochrome P-450: Modifications of the propendiol side chain, the p-nitrogroup, and the dichloromethyl moiety
29. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction
30. The carbon monoxidebinding pigment of liver microsomes
31. N-Benzylimidazole, a high magnitude inducer of rat hepatic cytochrome P-450 exhibiting both polycyclic aromatic hydrocarbon- and phenobarbital-type induction of phase I and phase II drug-metabolizing enzymes
32. Induction and inhibition of rat hepatic drug metabolism by N-substituted imidazole drugs
33. High magnitude hepatic cytochrome P-450 induction by an N-substituted imidazole antimycotic, clotrimazole
34. Induction of the rat hepatic microsomal mixedfunction oxidases by 3 imidazole-containing antifungal agents: Selectively for the cytochrome P450IIB and P-450III families of cytochrome P450
35. Comparative induction of cytochrome P4504A in rat hepatocyte culture by proliferators, bifonazole and clofibrate
36. Influence of some novel N-substituted azoles and pyridines on rat hepatic CYP3A activity
37. Phase II-selective induction of hepatic drugmetabolizing enzymes by oltipraz [5-(2pyrazinyl)-4-methyl-1,2-dithiol-3-thione], 1,7phenanthroline, and 2,2′-dipyridyl in rats is not accompanied by induction of intestinal enzymes
38. Differential Induction of 3 dipyridyl isomers on hepatic microsomal cytochrome P450 and heme oxygenase in rats