Itraconazole- and fluconazole-induced toxicity in rat hepatocytes: A comparative in vitro study

Human and Experimental Toxicology

Volumn 21, Issue 1, 2002, Pages 43-48

  Somchit, N ^a   Hassim, S M ^a   Samsudin, S H ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Antifungal; Fluconazole; Hepatotoxicity; Itraconazole; Rat

Indexed keywords

ANTIFUNGAL AGENT; CYTOCHROME P450; FLUCONAZOLE; ITRACONAZOLE; LACTATE DEHYDROGENASE; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; FEMALE; IN VITRO STUDY; INCUBATION TIME; LIVER CELL; LIVER TOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; TOXICITY TESTING; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECT; ENZYME INDUCTION; ENZYMOLOGY; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TIME;

ANIMAL; ANTIFUNGAL AGENTS; CELL SURVIVAL; CELLS, CULTURED; COMPARATIVE STUDY; CYTOCHROME P-450 ENZYME SYSTEM; CYTOPROTECTION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; FEMALE; FLUCONAZOLE; HEPATOCYTES; ITRACONAZOLE; LACTATE DEHYDROGENASE; PHENOBARBITAL; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; ANIMALS; L-LACTATE DEHYDROGENASE;

ANIMALIA;

EID: 0036000089     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327102ht208oa     Document Type: Article

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