Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury

Journal of Neuroimmunology

Volumn 174, Issue 1-2, 2006, Pages 119-125

  Pan, Weihong ^a   Cain, Courtney ^a   Yu, Yongmei ^a   Kastin, Abba J ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Blood brain barrier; Cytokine; LIF; Neuroregeneration; Transport

Indexed keywords

ALBUMIN TC 99M; LEUKEMIA INHIBITORY FACTOR; LEUKEMIA INHIBITORY FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD; BLOOD BRAIN BARRIER; BRAIN MICROCIRCULATION; CHROMATOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTHELIUM CELL; IMMUNOFLUORESCENCE; INFLAMMATION; ISCHEMIA; ISOTOPE LABELING; LUMBAR SPINAL CORD; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SPINAL CORD INJURY; STAINING; STATISTICAL SIGNIFICANCE; TISSUE REPAIR; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTIBODIES; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CAPILLARY PERMEABILITY; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INTERLEUKIN-6; IODINE ISOTOPES; LEUKEMIA INHIBITORY FACTOR; LEUKEMIA INHIBITORY FACTOR RECEPTOR ALPHA SUBUNIT; MALE; MICE; PROTEIN TRANSPORT; RECEPTORS, CYTOKINE; RECEPTORS, OSM-LIF; SPINAL CORD INJURIES; TIME FACTORS;

EID: 33646103677     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2006.02.006     Document Type: Article

References (25)

1. Banks W.A., and Kastin A.J. Passage of peptides across the blood-brain barrier: pathophysiological perspectives. Life Sci. 59 (1996) 1923-1943
2. Begley D.J. Peptides and the blood-brain barrier: the status of our understanding. Ann. N. Y. Acad. Sci. 739 (1994) 89-100
3. Blesch A., Uy H.S., Grill R.J., Cheng J.G., Patterson P.H., and Tuszynski M.H. Leukemia inhibitory factor augments neurotrophin expression and corticospinal axon growth after adult CNS injury. J. Neurosci. 19 (1999) 3556-3566
4. Butzkueven H., Zhang J.-G., Soilu-Hanninen M., Hochrein H., Chionh F., Shipham K.A., Emery B., Turnley A.M., Petratos S., Ernst M., Bartlett P.F., and Kilpatrick T.J. LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival. Nat. Med. 8 (2002) 613-619
5. Deguchi Y., Okutsu H., Okura T., Yamada S., Kimura R., Yuge T., Furukawa A., Morimoto K., Tachikawa M., Ohtsuki S., Hosoya K., and Terasaki T. Internalization of basic fibroblast growth factor at the mouse blood-brain barrier involves perlecan, a heparan sulfate proteoglycan. J. Neurochem. 83 (2002) 381-389
6. Gearing D.P., Gough N.M., King J.A., Hilton D.J., Nicola N.A., Simpson R.J., Nice E.C., Kelso A., and Metcalf D. Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J. 6 (1987) 3995-4002
7. Hosoya K., Tetsuka K., Nagase K., Tomi M., Saeki S., Ohtsuki S., and Terasaki T. Conditionally immortalized brain capillary endothelial cell lines established from a transgenic mouse harboring temperature-sensitive Simian virus 40 large T-antigen gene. AAPS PharmSci 2 (2000) 1-11
8. Huber J.D., Witt K.A., Hom S., Egleton R.D., Mark K.S., and Davis T.P. Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression. Am. J. Physiol. 280 (2001) H1241-H1248
9. Kastin A.J., Akerstrom V., and Pan W. Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls. Peptides 22 (2001) 2127-2136
10. Kurek J.B., Bennett T.M., Bower J.J., Muldoon C.M., and Austin L. Leukaemia inhibitory factor (LIF) production in a mouse model of spinal trauma. Neurosci. Lett. 249 (1998) 1-4
11. Kurek J.B., Radford A.J., Crump D.E., Bower J.J., Feeney S.J., Austin L., and Byrne E. LIF (AM424), a promising growth factor for the treatment of ALS. J. Neurol. Sci. 160 (1998) S106-S113
12. Li M., Sendtner M., and Smith A. Essential function of LIF receptor in motor neurons. Nature 378 (1995) 724-727
13. Pan W., and Kastin A.J. Interactions of IGF-1 with the blood-brain barrier in vivo and in situ. Neuroendocrinology 72 (2000) 171-178
14. Pan W., and Kastin A.J. Increase in TNFa transport after SCI is specific for time, region, and type of lesion. Exp. Neurol. 170 (2001) 357-363
15. Pan W., and Kastin A.J. Upregulation of the transport system for TNFa at the blood-brain barrier. Arch. Physiol. Biochem. 109 (2001) 350-353
16. Pan W., and Kastin A.J. Transport of cytokines and neurotrophins across the BBB and their regulation after spinal cord injury. In: Shanker H., and Westman J. (Eds). Blood-Spinal Cord and Brain Barriers in Health and Disease (2003), Academic Press 395-407
17. Pan W., Banks W.A., Fasold M.B., Bluth J., and Kastin A.J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37 (1998) 1553-1561
18. Pan W., Kastin A.J., Bell R.L., and Olson R.D. Upregulation of tumor necrosis factor a transport across the blood-brain barrier after acute compressive spinal cord injury. J. Neurosci. 19 (1999) 3649-3655
19. Pan W., Kastin A.J., and Brennan J.M. Saturable entry of leukemia inhibitory factor from blood to the central nervous system. J. Neuroimmunol. 106 (2000) 172-180
20. Pan W., Csernus B., and Kastin A.J. Upregulation of p55 and p75 receptors mediating TNF-alpha transport across the injured blood-spinal cord barrier. J. Mol. Neurosci. 21 (2003) 173-184
21. Pan W., Zhang L., Liao J., Csernus B., and Kastin A.J. Selective increase in TNFa permeation across the blood-spinal cord barrier after SCI. J. Neuroimmunol. 134 (2003) 111-117
22. Pan W., Kastin A.J., Zankel T., van Kerkhof P., Terasaki T., and Bu G. Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier. J. Cell Sci. 117 (2004) 5071-5078
23. Pan W., Ding Y., Yu Y., Ohtaki H., Nakamachi T., and Kastin A.J. Stroke upregulates TNF transport across the blood-brain barrier. Exp. Neurol. 198 (2006) 222-223
24. Strand F.L. Neuropeptides: Regulators of Physiological Processes (1999), MIT Press, Cambridge, MA
25. Tamai I., and Tsuji A. Transporter-mediated permeation of drugs across the blood-brain barrier. J. Pharm. Sci. 89 (2000) 1371-1388