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Volumn 11, Issue 9-10, 2006, Pages 452-457

Small organic molecules that modulate gene transcription

Author keywords

[No Author keywords available]

Indexed keywords

ADAMANOLOL; CCAAT ENHANCER BINDING PROTEIN BETA; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DEXAMETHASONE DERIVATIVE; DISTAMYCIN A; DNA; HEAT SHOCK PROTEIN; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMIDAZOLINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; ISOXAZOLIDINE DERIVATIVE; KG 501; NAPHTHOL DERIVATIVE; NUTLIN; NUTLIN 1; NUTLIN 2; NUTLIN 3; PROTEIN MDM2; PROTEIN P53; RNA POLYMERASE II; STEROID HORMONE; SYNTHETIC PEPTIDE; SYNTHETIC TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; WRENCHNOLOL;

EID: 33646096458     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2006.03.011     Document Type: Review
Times cited : (9)

References (34)
  • 1
    • 0034830898 scopus 로고    scopus 로고
    • Molecular recognition of DNA by small molecules
    • Dervan P.B. Molecular recognition of DNA by small molecules. Bioorg. Med. Chem. 9 (2001) 2215-2235
    • (2001) Bioorg. Med. Chem. , vol.9 , pp. 2215-2235
    • Dervan, P.B.1
  • 2
    • 0030951207 scopus 로고    scopus 로고
    • Regulation of gene expression by small molecules
    • Gottesfeld J.M., et al. Regulation of gene expression by small molecules. Nature 387 (1997) 202-205
    • (1997) Nature , vol.387 , pp. 202-205
    • Gottesfeld, J.M.1
  • 3
    • 0032573224 scopus 로고    scopus 로고
    • Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands
    • Dickinson L.A., et al. Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 12890-12895
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 12890-12895
    • Dickinson, L.A.1
  • 4
    • 10044258467 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
    • Olenyuk B.Z., et al. Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 16768-16773
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 16768-16773
    • Olenyuk, B.Z.1
  • 5
    • 0012473279 scopus 로고
    • The nuclear receptor superfamily: the second decade
    • Mangelsdorf D.J., et al. The nuclear receptor superfamily: the second decade. Cell 83 (1995) 835-839
    • (1995) Cell , vol.83 , pp. 835-839
    • Mangelsdorf, D.J.1
  • 6
    • 0032511086 scopus 로고    scopus 로고
    • Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors
    • Feng W., et al. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors. Science 280 (1998) 1747-1749
    • (1998) Science , vol.280 , pp. 1747-1749
    • Feng, W.1
  • 7
    • 0028970090 scopus 로고
    • Structure and function of transcriptional activation domains
    • Triezenberg S.J. Structure and function of transcriptional activation domains. Curr. Opin. Genet. Dev. 5 (1995) 190-196
    • (1995) Curr. Opin. Genet. Dev. , vol.5 , pp. 190-196
    • Triezenberg, S.J.1
  • 8
    • 0028337542 scopus 로고
    • Transcriptional activation: a complex puzzle with few easy pieces
    • Tjian R., and Maniatis T. Transcriptional activation: a complex puzzle with few easy pieces. Cell 77 (1994) 5-8
    • (1994) Cell , vol.77 , pp. 5-8
    • Tjian, R.1    Maniatis, T.2
  • 9
    • 0030756675 scopus 로고    scopus 로고
    • Induced alpha helix in the VP16 activation domain upon binding to a human TAF
    • Uesugi M., et al. Induced alpha helix in the VP16 activation domain upon binding to a human TAF. Science 277 (1997) 1310-1313
    • (1997) Science , vol.277 , pp. 1310-1313
    • Uesugi, M.1
  • 10
    • 0033592822 scopus 로고    scopus 로고
    • The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2
    • Uesugi M., and Verdine G.L. The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 14801-14806
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 14801-14806
    • Uesugi, M.1    Verdine, G.L.2
  • 11
    • 0034716850 scopus 로고    scopus 로고
    • Divergent hTAFII31-binding motifs hidden in activation domains
    • Choi Y., et al. Divergent hTAFII31-binding motifs hidden in activation domains. J. Biol. Chem. 275 (2000) 15912-15916
    • (2000) J. Biol. Chem. , vol.275 , pp. 15912-15916
    • Choi, Y.1
  • 12
    • 0023500809 scopus 로고
    • Transcription in yeast activated by a putative amphipathic alpha helix linked to a DNA binding unit
    • Giniger E., and Ptashne M. Transcription in yeast activated by a putative amphipathic alpha helix linked to a DNA binding unit. Nature 330 (1987) 670-672
    • (1987) Nature , vol.330 , pp. 670-672
    • Giniger, E.1    Ptashne, M.2
  • 13
    • 0030575937 scopus 로고    scopus 로고
    • Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    • Kussie P.H., et al. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 274 (1996) 948-953
    • (1996) Science , vol.274 , pp. 948-953
    • Kussie, P.H.1
  • 14
    • 0344936739 scopus 로고    scopus 로고
    • Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions
    • Radhakrishnan I., et al. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell 91 (1997) 741-752
    • (1997) Cell , vol.91 , pp. 741-752
    • Radhakrishnan, I.1
  • 15
    • 0037117479 scopus 로고    scopus 로고
    • Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha
    • Freedman S.J., et al. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 5367-5372
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 5367-5372
    • Freedman, S.J.1
  • 16
    • 0037117486 scopus 로고    scopus 로고
    • Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response
    • Dames S.A., et al. Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 5271-5276
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 5271-5276
    • Dames, S.A.1
  • 17
    • 0033813065 scopus 로고    scopus 로고
    • Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha
    • Rose R.B., et al. Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha. Nat. Struct. Biol. 7 (2000) 744-748
    • (2000) Nat. Struct. Biol. , vol.7 , pp. 744-748
    • Rose, R.B.1
  • 18
    • 37049183697 scopus 로고
    • Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon D.J., et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235 (1987) 177-182
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1
  • 19
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon D.J., et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244 (1989) 707-712
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1
  • 20
    • 8244259923 scopus 로고    scopus 로고
    • ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis
    • Chang C.H., et al. ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis. Oncogene 14 (1997) 1617-1622
    • (1997) Oncogene , vol.14 , pp. 1617-1622
    • Chang, C.H.1
  • 21
    • 0028120273 scopus 로고
    • Binding of an ETS-related protein within the DNase I hypersensitive site of the HER2/neu promoter in human breast cancer cells
    • Scott G.K., et al. Binding of an ETS-related protein within the DNase I hypersensitive site of the HER2/neu promoter in human breast cancer cells. J. Biol. Chem. 269 (1994) 19848-19858
    • (1994) J. Biol. Chem. , vol.269 , pp. 19848-19858
    • Scott, G.K.1
  • 22
    • 0036790811 scopus 로고    scopus 로고
    • External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator
    • Asada S., et al. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 12747-12752
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 12747-12752
    • Asada, S.1
  • 23
    • 0040368298 scopus 로고    scopus 로고
    • Composite co-activator ARC mediates chromatin-directed transcriptional activation
    • Naar A.M., et al. Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature 398 (1999) 828-832
    • (1999) Nature , vol.398 , pp. 828-832
    • Naar, A.M.1
  • 24
    • 0033614417 scopus 로고    scopus 로고
    • Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
    • Rachez C., et al. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 398 (1999) 824-828
    • (1999) Nature , vol.398 , pp. 824-828
    • Rachez, C.1
  • 25
    • 0033587187 scopus 로고    scopus 로고
    • Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
    • Boyer T.G., et al. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. Nature 399 (1999) 276-279
    • (1999) Nature , vol.399 , pp. 276-279
    • Boyer, T.G.1
  • 26
    • 0033521956 scopus 로고    scopus 로고
    • The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1
    • Ryu S., et al. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Nature 397 (1999) 446-450
    • (1999) Nature , vol.397 , pp. 446-450
    • Ryu, S.1
  • 27
    • 0037473529 scopus 로고    scopus 로고
    • A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction
    • Asada S., et al. A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction. J. Am. Chem. Soc. 125 (2003) 4992-4993
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 4992-4993
    • Asada, S.1
  • 28
    • 1642291800 scopus 로고    scopus 로고
    • A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction
    • Shimogawa H., et al. A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction. J. Am. Chem. Soc. 126 (2004) 3461-3471
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 3461-3471
    • Shimogawa, H.1
  • 29
    • 11144231977 scopus 로고    scopus 로고
    • Identification of small-molecule antagonists that inhibit an activator: coactivator interaction
    • Best J.L., et al. Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 17622-17627
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 17622-17627
    • Best, J.L.1
  • 30
    • 0025894713 scopus 로고
    • p53 mutations in human cancers
    • Hollstein M., et al. p53 mutations in human cancers. Science 253 (1991) 49-53
    • (1991) Science , vol.253 , pp. 49-53
    • Hollstein, M.1
  • 31
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev L.T., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 (2004) 844-848
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1
  • 32
    • 10344232709 scopus 로고    scopus 로고
    • Small molecule transcription factor mimic
    • Kwon Y., et al. Small molecule transcription factor mimic. J. Am. Chem. Soc. 126 (2004) 15940-15941
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 15940-15941
    • Kwon, Y.1
  • 33
    • 4344672780 scopus 로고    scopus 로고
    • A small molecule transcriptional activation domain
    • Minter A.R., et al. A small molecule transcriptional activation domain. J. Am. Chem. Soc. 126 (2004) 10504-10505
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 10504-10505
    • Minter, A.R.1
  • 34
    • 20444464372 scopus 로고    scopus 로고
    • A potent transactivation domain mimic with activity in living cells
    • Liu B., et al. A potent transactivation domain mimic with activity in living cells. J. Am. Chem. Soc. 127 (2005) 8254-8255
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 8254-8255
    • Liu, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.