Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period

Journal of Lipid Research

Volumn 44, Issue 11, 2003, Pages 2065-2072

  Heath, Richard B ^a   Karpe, Fredrik ^a   Milne, Ross W ^b   Burdge, Graham C ^c   Wootton, Stephen A ^c   Frayn, Keith N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Apolipoprorein B; Chylomicron; Immunoaffinity chromatography; N 3 polyunsaturated fatty acids; Palmitic acid; Stable isotopes; Triacylglycerol

Indexed keywords

APOLIPOPROTEIN B100; CHYLOMICRON; DOCOSAHEXAENOIC ACID; FATTY ACID; FISH OIL; ICOSAPENTAENOIC ACID; PALMITIC ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ANTIBODY AFFINITY; ARTICLE; BODY MASS; DIETARY INTAKE; FAT INTAKE; FEMALE; FISH; GAS CHROMATOGRAPHY; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0345098362     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: 10.1194/jlr.M300167-JLR200     Document Type: Article

References (36)

1. Austin, M. A. 1991. Plasma triglyceride and coronary heart disease. Arterioscler. Thromb. 11: 2-14.
2. Zilversmit, D. B. 1979. Atherogenesis: a postprandial phenomenon. Circulation. 60: 473-485.
3. Cohn, J. S., E. J. Johnson, J. S. Millar, S. D. Cohn, R. W. Milne, Y. L. Marcel, R. M. Russell, and E. J. Schaefer. 1993. Contribution of apoB-48 and apoB-100 triglyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides and retinyl esters. J. Lipid Res. 34: 2033-2040.
4. Schneeman, B. O., L. Kotite, K. M. Todd, and R. J. Havel. 1993. Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans. Proc. Natl. Acad. Sci. USA. 90: 2069-2073.
5. Bergeron, N., and R. J. Havel. 1995. Influence of diets rich in saturated and omega-6 polyunsaturated fatty acids on the postprandial responses of apolipoproteins B-48, B-100, E, and lipids in triglyceride-rich lipoproteins. Arterioscler. Thromb. Vasc. Biol. 15: 2111-2121.
6. Kane, J. P., D. A. Hardman, and H. E. Paulus. 1980. Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons. Proc. Natl. Acad. Sci. USA. 77: 2465-2469.
7. Powell, L. M., S. C. Wallis, R. J. Pease, Y. H. Edwards, T. J. Knott, and J. Scott. 1987. A novel form of tissue-specific RNA processing produces apolipoprotein-B-48 in intestine. Cell. 50: 831-840.
8. Milne, R. W., P. K. Weech, L. Blanchette, J. Davignon, P. Alaupovic, and Y. L. Marcel. 1984. Isolation and characterization of apolipoprotein B-48 and B-100 very low density lipoproteins from type III hyperlipoproteinemic subjects. J. Clin. Invest. 73: 816-823.
9. Björkegren, J., A. Hamsten, R. W. Milne, and F. Karpe. 1997. Alterations of VLDL composition during alimentary lipemia. J. Lipid Res. 38: 301-314.
10. Björkegren, J., F. Karpe, R. W. Milne, and A. Hamsten. 1998. Differences in apolipoprotein and lipid composition between human chylomicron remnants and very low density lipoproteins isolated from fasting and postprandial plasma. J. Lipid Res. 39: 1412-1420.
11. Björkegren, J., S. Boquist, A. Samnegård, P. Lundman, P. Tornvall, C. G. Ericsson, and A. Hamsten. 2000. Accumulation of apolipoprotein C-I-rich and cholesterol-rich VLDL remnants during exaggerated postprandial triglyceridemia in normolipidemic patients with coronary artery disease. Circulation. 101: 227-230.
12. Terce, F., R. W. Milne, P. K. Weech, J. Davignon, and Y. L. Marcel. 1985. Apolipoprotein B-48 and B-100 very low density lipoproteins. Comparison in dysbetalipoproteinemia (type III) and familial hypertriglyceridemia (type IV). Arteriosclerosis. 5: 201-211.
13. Frayn, K. N., S. W. Coppack, B. A. Fielding, and S. M. Humphreys. 1995. Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization. Adv. Enzyme. Regul. 35:163-178.
14. Coppack, S. W., R. M. Fisher, G. F. Gibbons, S. M. Humphreys, M. J. McDonough, J. L. Potts, and K. N. Frayn. 1990. Postprandial substrate deposition in human forearm and adipose tissues in vivo. Clin. Sci. 79: 339-348.
15. Summers, L. K., S. C. Barnes, B. A. Fielding, C. Beysen, V. Ilic, S. M. Humphreys, and K. N. Frayn. 2000. Uptake of individual fatty acids into adipose tissue in relation to their presence in the diet. Am. J. Clin. Nutr. 71: 1470-1477.
16. Gibney, M. J., and E. Daly. 1994. The incorporation of n-3 polyunsaturated fatty acids into plasma lipid and lipoprotein fractions in the postprandial phase in healthy volunteers. Eur. J. Clin. Nutr. 48: 866-872.
17. Zuijdgeest van Leeuwen, S. D., P. C. Dagnelie, T. Rietveld, J. W. van den Berg, and J. H. Wilson. 1999. Incorporation and washout of orally administered n-3 fatty acid ethyl esters in different plasma lipid fractions. Br. J. Nutr. 82: 481-488.
18. Sanders, T. A., A. Hinds, and C. C. Pereira. 1989. Influence of n-3 fatty acids on blood lipids in normal subjects. J. Intern. Med. 225 (Suppl.): 99-104.
19. Leaf, D. A., W. E. Connor, L. Barstad, and G. Sexton. 1995. Incorporation of dietary n-3 fatty acids into the fatty acids of human adipose tissue and plasma lipid classes. Am. J. Clin. Nutr. 62: 68-73.
20. Sadou, H., C. L. Leger, B. Descomps, J. N. Barjon, L. Monnier, and A. Crastes de Paulet. 1995. Differential incorporation of fish-oil eicosapentaenoate and docosahexaenoate into lipids of lipoprotein fractions as related to their glyceryl esterification: a short-term (postprandial) and long-term study in healthy humans. Am. J. Clin. Nutr. 62: 1193-1200.
21. Karpe, F., G. Steiner, T. Olivecrona, L. A. Carlson, and A. Hamsten. 1993. Metabolism of triglyceride-rich lipoproteins during alimentary lipemia. J. Clin. Invest. 91: 748-758.
22. Marcel, Y. L., M. Hogue, R. Theolis, Jr., and R. W. Milne. 1982. Mapping of antigenic determinants of human apolipoprotein B using monoclonal antibodies against low density lipoproteins. J. Biol. Chem. 257: 13165-13168.
23. Karpe, F., and A. Hamsten. 1994. Determination of apolipoproteins B-48 and B-100 in triglyceride-rich lipoproteins by analytical SDS-PAGE. J. Lipid Res. 35: 1311-1317.
24. Folch, J., M. Lees, and G. Sloane Stanley. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226: 497-509.
25. Fielding, B. A., J. Callow, R. M. Owen, J. S. Samra, D. R. Matthews, and K. N. Frayn. 1996. Postprandial lipemia: the origin of an early peak studied by specific dietary fatty acid intake during sequential meals. Am. J. Clin. Nutr. 63: 36-41.
26. Burdge, G. C., P. Wright, A. E. Jones, and S. A. Wootton. 2000. A method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid-phase extraction. Br. J. Nutr. 84: 781-787.
27. Evans, K., G. C. Burdge, S. A. Wootton, M. L. Clark, and K. N. Frayn. 2002. Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. Diabetes. 51: 2684-2690.
28. Campos, E., K. Nakajima, A. Tanaka, and R. J. Havel. 1992. Properties of an apolipoprotein E-enriched fraction of triglyceride-rich lipoproteins isolated from human blood plasma with a monoclonal antibody to apolipoprotein B-100. J. Lipid Res. 33: 369-380.
29. Fukuda, N., and J. A. Ontko. 1984. Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver. J. Lipid Res. 25: 831-842.
30. Welty, F. K., A. H. Lichtenstein, P. H. Barrett, G. G. Dolnikowski, and E. J. Schaefer. 1999. Human apolipoprotein (Apo) B-48 and ApoB-100 kinetics with stable isotopes. Arterioscler. Thromb. Vasc. Biol. 19: 2966-2974.
31. Karpe, F., T. Olivecrona, A. Hamsten, and M. Hultin. 1997. Chylomicron/chylomicron remnant turnover in humans: evidence for margination of chylomicrons and poor conversion of larger to smaller chylomicron remnants. J. Lipid Res. 38: 949-961.
32. Wilson, D. E., and I. F. Chan. 1983. In vitro transfer of chylomicron retinol and retinyl esters. Biochem. Biophys. Res. Commun. 115: 958-964.
33. Zilversmit, D. B., R. E. Morton, L. B. Hughes, and K. H. Thompson. 1982. Exchange of retinyl and cholesteryl esters between lipoproteins of rabbit plasma. Biochim. Biophys. Acta. 712: 88-93.
34. Hultin, M., R. Savonen, and T. Olivecrona. 1996. Chylomicron metabolism in rats: lipolysis, recirculation of triglyceride-derived fatty acids in plasma FFA, and fate of core lipids as analyzed by compartmental modelling. J. Lipid Res. 37: 1022-1036.
35. Ekström, B., A. Nilsson, and B. Akesson. 1989. Lipolysis of polyenoic fatty acid esters of human chylomicrons by lipoprotein lipase. Eur. J. Clin. Invest. 19: 259-264.
36. Melin, T., C. Qi, G. Bengtsson-Olivecrona, B. Åkesson, and A. Nilsson. 1991. Hydrolysis of chylomicron polyenoic fatty acid esters with lipoprotein lipase and hepatic lipase. Biochim. Biophys. Acta. 1075: 259-266.