Cocoa and cardiovascular health: The sweet heart protection

Agro Food Industry Hi-Tech

Volumn 17, Issue 1, 2006, Pages

  Grassi, Davide ^a   Desideri, Giovanbattista ^a   Croce, Giuseppe ^a   Lippi, Cristina ^a   Ferri, Claudio ^a   Pasqualetti, Paolo ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HEART PROTECTION;

FOOD TECHNOLOGY;

THEOBROMA CACAO;

EID: 33646029972     PISSN: 17226996     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (48)

1. T.L. Dillinger et al., "Food of the Gods: Cure for the Humanity? A cultural history of the medicinal and ritual use of chocolate", J. Nutr., 130, 2057S-2072S (2000)
2. E.L. Ding et al., "Chocolate and prevention of cardiovascular disease: A systematic review", Nutrition & Metabolism, 3, p. 2 (2006) doi:10.1186/1743-7075-3-2
3. E.B. Rimm et al., "Vegetable, fruit, and cereal fiber intake and risk of coronary heart disease among men", JAMA, 14; 275(6), pp. 447-451 (1996)
4. L.I. Mennen et al., "Consumption of foods rich in flavonoids is related to a decreased cardiovascular risk in apparently healthy French women", J Nutr., 134(4), pp. 923-926 (2004)
5. M.G. Hertog et al., "Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study", Lancet, 342(8878), pp. 1007-1011 (1993)
6. M.G. Hertog et al., "Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study", Arch Intern Med., 155(4), pp. 381-386 (1995)
7. A. Scalbert et al., "Dietary polyphenols and the prevention of diseases", Crit Rev Food Sci Nutr., 45(4), pp. 287-306 (2005)
8. L. Gu et al., "Concentrations of proanthocyanidins in common foods and estimations of normal consumption", J Nutr., 134(3), pp. 613-617 (2004)
9. F.M. Steinberg et al., "Cocoa and chocolate flavonoids: implications for cardiovascular health", J Am Diet Assoc., 103(2), pp. 215-223 (2003)
10. J.F. Hammerstone et al., "Identification of procyanidins in cocoa (Theobroma cacao) and chocolate using high-performance liquid chromatography/mass spectrometry", J Agric Food Chem., 47(2), pp. 490-496 (1999)
11. J. Wollgast, E. Anklam, "Review on polyphenols in Theobroma cacao: changes in composition during the manufacture of chocolate and methodology for identification and quantification", Food Research International, 33, pp. 423-447 (2000)
12. S. Deprez et al., "Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells", Antioxid Redox Signal., 3(6), pp. 957-967 (2001)
13. M.J. Lee et al., "Analysis of plasma and urinary tea polyphenols in human subjects", Cancer Epidemiol. Biomarkers Prev., 4, pp. 393-399 (1995)
14. A. Scalbert, G. Williamson, "Dietary intake and bioavailability of polyphenols", J. Nutr., 130, 2273S-2285S (2000)
15. J.P.E. Spencer et al., "Bioavailability of flavan-3-ols and procyanidins: gastrointestinal tract influences and their relevance to be active forms in vivo", Antioxid. Redox. Signal., 3, pp. 1023-1039 (2001)
16. S. Baba et al., "Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers", Free Radic. Res., 33, pp. 635-641 (2000)
17. M. Richelle et al., "Plasma kinetics in men of epicatechin from black chocolate", Eur J Clin. Nutr., 53, pp. 22-26 (1999)
18. R. Rein et al., "Epicatechin in human plasma; in vivo determination and effect of chocolate consumption on plasma antioxidant capacity", J. Nutr., 130, 2109S-2114S (2000)
19. J.F. Wang et al., "A dose-response effect from chocolate consumption on plasma epicatechin and oxidative damage", J Nutr., 130(8S Suppl), 2115S-9S (2000)
20. R.R. Holt et al., "Procyanidin dimmer B2 [epicatechin-(4β-8)-epicatechin] in human plasma after the consumption of a flavanol-rich cocoa", Am J Clin Nutr., 76, pp. 798-804 (2002)
21. N.K. Hollenberg et al., "Aging, acculturation, salt intake, and hypertension in the Kuna of Panama", Hypertension, 29(1 Pt 2), pp. 171-176 (1997)
22. K.A. Chevaux et al., "Proximate mineral and procyanidin content of certain foods and beverages consumed by the Kuna Amerinds of Panama", J Food Comp Analysis, 14, pp. 553-563 (2001)
23. J.M. Geleijnse et al., "Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study", Am J Clin Nutr., 75(5), pp. 880-886 (2002)
24. K.J. Mukamal et al., "Tea consumption and mortality after acute myocardial infarction", Circulation, 105(21), pp. 2476-2481 (2002)
25. H. Brunner et al.," Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension", J Hypertens, 23(2), pp. 233-246 (2005)
26. S. Taddei et al., "Endothelial dysfunction in hypertension", J Nephrol., 13(3), pp. 205-210 (2000)
27. D.F. Fitzpatrick et al., "Endothelium-dependent vasorelaxation caused by various plant extracts", J Cardiovasc Pharmacol., 26(1), pp. 90-95 (1995)
28. E. Andriambeloson et al., "Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta", Br J Pharmacol., 120(6), pp. 1053-1058 (1997)
29. J.F. Leikert et al., "Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells", Circulation, 106(13), pp. 1614-1617 (2002)
30. G.E. Arteel et al., "Reactions of peroxynitrite with cocoa procyanidin oligomers", J Nutr., 130, 2100S-2104S (2000)
31. W.A. Pryor, G.L. Squadrito, "The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide", Am J Physiol., 268, L698-K722 (1995)
32. G. Desideri, C. Ferri, "Endothelial activation. Sliding door to atherosclerosis", Curr Pharm Des., 11(17), pp. 2163-2175 (2005)
33. M. Karim et al., "Effects of cocoa extracts on endothelium-dependent relaxation", J Nutr., 130(8S Suppl), 2105S-8S (2000)
34. N.D. Fisher et al., "Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans", J Hypertens, 21(12), pp. 2281-2286 (2003)
35. O. Pechanova et al., "Vasoactive systems in L-NAME hypertension: the role of inducible nitric oxide synthase", J Hypertens., 22(1), pp. 167-173 (2004)
36. C. Heiss et al., "Vascular effects of cocoa rich in flavan-3-ols", JAMA, 290(8), pp. 1030-1031 (2003)
37. D. Grassi et al., "Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons", Am J Clin Nutr., 81(3), pp. 611-614 (2004)
38. D. Grassi et al., "Cocoa reduces blood pressure and insulin resistance and improves endothelium-dependent vasodilation in hypertensives", Hypertension, 46(2), pp. 398-405 (2005)
39. H. Schroeter et al., "(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans", Proc Natl Acad Sci U S A, 103(4), pp. 1024-1029 (2006)
40. D. Taubert et al., "Chocolate and blood pressure in elderly individuals with isolated systolic hypertension", JAMA, 290(8), pp. 1029-1030 (2003)
41. C.G. Fraga et al., "Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer players", Clin Dev Immunol., 12(1), pp. 11-17 (2005)
42. M.B. Engler et al., "Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults", J Am Coll Nutr., 23(3), pp. 197-204 (2004)
43. S.J. Cleland et al., "Insulin as a vascular hormone: implications for the pathophysiology of cardiovascular disease", Clin Exp Pharmacol Physiol., 25(3-4), pp. 175-184 (1998)
44. D. Rein et al., "Cocoa inhibits platelet activation and function", Am J Clin Nutr., 72(1), pp. 30-35 (2000)
45. J.G. Keevil et al., "Grape juice, but not orange juice or grapefruit juice, inhibits human platelet aggregation", J Nutr., 130(1), pp. 53-56 (2000)
46. D.A. Pearson et al., "The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function", Thromb Res., 106(4-5), pp. 191-197 (2002)
47. K.J. Murphy et al., "Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function", Am J Clin Nutr., 77(6), pp. 1466-1473 (2003)
48. D.D. Schramm et al., "Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells", Am J Clin Nutr., 73(1), pp. 36-40 (2001)