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Volumn 22, Issue 9, 2003, Pages 2060-2070

Importin α-regulated nucleation of microtubules by TPX2

Author keywords

Importin ; Nuclear localization sequence; Ran; Spindle assembly; TPX2

Indexed keywords

GUANOSINE TRIPHOSPHATASE; KARYOPHERIN ALPHA; MICROTUBULE ASSOCIATED PROTEIN; MUTANT PROTEIN; TPX2 PROTEIN; UNCLASSIFIED DRUG;

EID: 0038558166     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdg195     Document Type: Article
Times cited : (152)

References (39)
  • 1
    • 0036911347 scopus 로고    scopus 로고
    • The Ran GTPase cycle and importins α and β are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos
    • Askjaer, P., Galy, V., Hannak, E. and Mattaj, I.W. (2002) The Ran GTPase cycle and importins α and β are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol. Biol. Cell, 13, 4355-4370.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 4355-4370
    • Askjaer, P.1    Galy, V.2    Hannak, E.3    Mattaj, I.W.4
  • 2
    • 0036006303 scopus 로고    scopus 로고
    • The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo
    • Bamba, C., Bobinnec, Y., Fukuda, M. and Nishida, E. (2002) The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo. Curr. Biol., 12, 503-507.
    • (2002) Curr. Biol. , vol.12 , pp. 503-507
    • Bamba, C.1    Bobinnec, Y.2    Fukuda, M.3    Nishida, E.4
  • 4
    • 0033536178 scopus 로고    scopus 로고
    • Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation
    • Carazo-Salas, R.E., Guarguaglini, G., Gruss, O.J., Segref, A., Karsenti, E. and Mattaj, I.W. (1999) Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature, 400, 178-181.
    • (1999) Nature , vol.400 , pp. 178-181
    • Carazo-Salas, R.E.1    Guarguaglini, G.2    Gruss, O.J.3    Segref, A.4    Karsenti, E.5    Mattaj, I.W.6
  • 5
    • 0035090344 scopus 로고    scopus 로고
    • Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly
    • Carazo-Salas, R.E., Gruss, O.J., Mattaj, I.W. and Karsenti, E. (2001) Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly. Nat. Cell Biol., 3, 228-234.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 228-234
    • Carazo-Salas, R.E.1    Gruss, O.J.2    Mattaj, I.W.3    Karsenti, E.4
  • 6
    • 0034826896 scopus 로고    scopus 로고
    • Regulation of microtubule-associated proteins
    • Cassimeris, L. and Spittle, C. (2001) Regulation of microtubule-associated proteins. Int. Rey. Cytol., 210, 163-226.
    • (2001) Int. Rey. Cytol. , vol.210 , pp. 163-226
    • Cassimeris, L.1    Spittle, C.2
  • 7
    • 0035445281 scopus 로고    scopus 로고
    • Ran GTPase: A master regulator of nuclear structure and function during the eukaryotic cell division cycle?
    • Clarke, P.R. and Zhang, C. (2001) Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle? Trends Cell Biol., 11, 366-371.
    • (2001) Trends Cell Biol. , vol.11 , pp. 366-371
    • Clarke, P.R.1    Zhang, C.2
  • 8
    • 0033782853 scopus 로고    scopus 로고
    • Spindle assembly in animal cells
    • Compton, D.A. (2000) Spindle assembly in animal cells. Annu. Rev. Biochem., 69, 95-114.
    • (2000) Annu. Rev. Biochem. , vol.69 , pp. 95-114
    • Compton, D.A.1
  • 9
    • 0037162398 scopus 로고    scopus 로고
    • The Ran GTPase: Theme and variations
    • Dasso, M. (2002) The Ran GTPase: theme and variations. Curr. Biol., 12, R502-R508.
    • (2002) Curr. Biol. , vol.12
    • Dasso, M.1
  • 10
    • 0001298807 scopus 로고
    • Cryo-electron microscopy of vitrified biological specimen
    • Dubochet, J.M., Lepault, A.J. and McDowall, A.W. (1985) Cryo-electron microscopy of vitrified biological specimen. Trends Biochem. Sci., 10, 143-146.
    • (1985) Trends Biochem. Sci. , vol.10 , pp. 143-146
    • Dubochet, J.M.1    Lepault, A.J.2    McDowall, A.W.3
  • 11
    • 0034949769 scopus 로고    scopus 로고
    • The non-catalytic domain of the Xenopus laevis aurora A kinase localises the protein to the centrosome
    • Giet, R. and Prigent, C. (2001) The non-catalytic domain of the Xenopus laevis auroraA kinase localises the protein to the centrosome. J. Cell Sci., 114, 2095-2104.
    • (2001) J. Cell Sci. , vol.114 , pp. 2095-2104
    • Giet, R.1    Prigent, C.2
  • 12
    • 0027937653 scopus 로고
    • Isolation of a protein that is essential for the first step of nuclear protein import
    • Görlich, D., Prehn, S., Laskey, R.A. and Hartmann, E. (1994) Isolation of a protein that is essential for the first step of nuclear protein import. Cell, 79, 767-778.
    • (1994) Cell , vol.79 , pp. 767-778
    • Görlich, D.1    Prehn, S.2    Laskey, R.A.3    Hartmann, E.4
  • 13
    • 17744380396 scopus 로고    scopus 로고
    • Ran induces spindle assembly by reversing the inhibitory effect of importin α on TPX2 activity
    • Gruss, O.J. et al. (2001) Ran induces spindle assembly by reversing the inhibitory effect of importin α on TPX2 activity. Cell, 104, 83-93.
    • (2001) Cell , vol.104 , pp. 83-93
    • Gruss, O.J.1
  • 16
    • 0036306726 scopus 로고    scopus 로고
    • The Ran GTPase as a marker for chromosome position in spindle formation and nuclear envelope assembly
    • Hetzer, M., Gruss, O.J. and Mattaj, I.W. (2002) The Ran GTPase as a marker for chromosome position in spindle formation and nuclear envelope assembly. Nat. Cell Biol., 4, E177-E184.
    • (2002) Nat. Cell Biol. , vol.4
    • Hetzer, M.1    Gruss, O.J.2    Mattaj, I.W.3
  • 18
    • 0033528994 scopus 로고    scopus 로고
    • The Ran GTPase regulates mitotic spindle assembly
    • Kalab, P., Pu, R.T. and Dasso, M. (1999) The Ran GTPase regulates mitotic spindle assembly. Curr. Biol., 9, 481-484.
    • (1999) Curr. Biol. , vol.9 , pp. 481-484
    • Kalab, P.1    Pu, R.T.2    Dasso, M.3
  • 19
    • 0035913964 scopus 로고    scopus 로고
    • The mitotic spindle: A self-made machine
    • Karsenti, E. and Vernos, I. (2001) The mitotic spindle: a self-made machine. Science, 294, 543-547.
    • (2001) Science , vol.294 , pp. 543-547
    • Karsenti, E.1    Vernos, I.2
  • 20
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 277, 680-685.
    • (1970) Nature , vol.277 , pp. 680-685
    • Laemmli, U.K.1
  • 21
    • 0021711717 scopus 로고
    • Microtubule assembly nucleated by isolated centrosomes
    • Mitchison, T. and Kirschner, M. (1984) Microtubule assembly nucleated by isolated centrosomes. Nature, 312, 232-237.
    • (1984) Nature , vol.312 , pp. 232-237
    • Mitchison, T.1    Kirschner, M.2
  • 22
    • 0035312819 scopus 로고    scopus 로고
    • γ-tubulin complexes and microtubule nucleation
    • Moritz, M. and Agard, D.A. (2001) γ-tubulin complexes and microtubule nucleation. Curr. Opin. Struct. Biol., 11, 174-181.
    • (2001) Curr. Opin. Struct. Biol. , vol.11 , pp. 174-181
    • Moritz, M.1    Agard, D.A.2
  • 23
    • 0026266161 scopus 로고
    • Cell cycle extracts
    • Kay, B.K. and Peng, H.B. (eds), Academic Press, San Diego, CA
    • Murray, A. (1991) Cell cycle extracts. In Kay, B.K. and Peng, H.B. (eds), Xenopus laevis: Practical Uses in Cell and Molecular Biology, Vol. 36. Academic Press, San Diego, CA, pp. 581-605.
    • (1991) Xenopus Laevis: Practical Uses in Cell and Molecular Biology , vol.36 , pp. 581-605
    • Murray, A.1
  • 25
    • 0032972509 scopus 로고    scopus 로고
    • PSORT: A program for detecting sorting signals in proteins and predicting their subcellular localization
    • Nakai, K. and Horton, P. (1999) PSORT: a program for detecting sorting signals in proteins and predicting their subcellular localization. Trends Biochem. Sci., 24, 34-35.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 34-35
    • Nakai, K.1    Horton, P.2
  • 26
    • 0033591386 scopus 로고    scopus 로고
    • Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran
    • Ohba, T., Nakamura, M., Nishitani, H. and Nishimoto, T. (1999) Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran. Science, 284, 1356-1358.
    • (1999) Science , vol.284 , pp. 1356-1358
    • Ohba, T.1    Nakamura, M.2    Nishitani, H.3    Nishimoto, T.4
  • 27
    • 0037031151 scopus 로고    scopus 로고
    • XMAP215 is required for the microtubule-nucleating activity of centrosomes
    • Popov, A., Severin, F. and Karsenti, E. (2002) XMAP215 is required for the microtubule-nucleating activity of centrosomes. Curr. Biol., 12, 1326-1330.
    • (2002) Curr. Biol. , vol.12 , pp. 1326-1330
    • Popov, A.1    Severin, F.2    Karsenti, E.3
  • 28
    • 0026027192 scopus 로고
    • Mitotic spindle assembly by two different pathways in vitro
    • Sawin, K.E. and Mitchison, T.J. (1991) Mitotic spindle assembly by two different pathways in vitro. J. Cell Biol., 112, 925-940.
    • (1991) J. Cell Biol. , vol.112 , pp. 925-940
    • Sawin, K.E.1    Mitchison, T.J.2
  • 29
    • 0033954226 scopus 로고    scopus 로고
    • γ-tubulin complexes: Binding to the centrosome, regulation and microtubule nucleation
    • Schiebel, E. (2000) γ-tubulin complexes: binding to the centrosome, regulation and microtubule nucleation. Curr. Opin. Cell Biol., 12, 113-118.
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 113-118
    • Schiebel, E.1
  • 30
    • 0033792092 scopus 로고    scopus 로고
    • Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts
    • Tournebize, R. et al. (2000) Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts. Nat. Cell Biol., 2, 13-19.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 13-19
    • Tournebize, R.1
  • 31
    • 0032795910 scopus 로고    scopus 로고
    • Phosphorylation by CDK1 regulates XMAP215 function in vitro
    • Vasquez, R.J., Gard, D.L. and Cassimeris, L. (1999) Phosphorylation by CDK1 regulates XMAP215 function in vitro. Cell Motil. Cytoskeleton, 43, 310-321.
    • (1999) Cell Motil. Cytoskeleton , vol.43 , pp. 310-321
    • Vasquez, R.J.1    Gard, D.L.2    Cassimeris, L.3
  • 32
    • 0030454052 scopus 로고    scopus 로고
    • Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities
    • Weis, K., Dingwall, C. and Lamond, A.I. (1996) Characterization of the nuclear protein import mechanism using Ran mutants with altered nucleotide binding specificities. EMBO J., 15, 7120-7128.
    • (1996) EMBO J. , vol.15 , pp. 7120-7128
    • Weis, K.1    Dingwall, C.2    Lamond, A.I.3
  • 33
    • 0035951480 scopus 로고    scopus 로고
    • Role of importin β in coupling Ran to downstream targets in microtubule assembly
    • Wiese, C., Wilde, A., Moore, M.S., Adam, S.A., Merdes, A. and Zheng, Y. (2001) Role of importin β in coupling Ran to downstream targets in microtubule assembly. Science, 291, 653-656.
    • (2001) Science , vol.291 , pp. 653-656
    • Wiese, C.1    Wilde, A.2    Moore, M.S.3    Adam, S.A.4    Merdes, A.5    Zheng, Y.6
  • 34
    • 0033591373 scopus 로고    scopus 로고
    • Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran
    • Wilde, A. and Zheng, Y. (1999) Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran. Science, 284, 1359-1362.
    • (1999) Science , vol.284 , pp. 1359-1362
    • Wilde, A.1    Zheng, Y.2
  • 35
    • 0035090387 scopus 로고    scopus 로고
    • Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities
    • Wilde, A., Lizarraga, S.B., Zhang, L., Wiese, C., Gliksman, N.R., Walczak, C.E. and Zheng, Y. (2001) Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities. Nat. Cell Biol., 3, 221-227.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 221-227
    • Wilde, A.1    Lizarraga, S.B.2    Zhang, L.3    Wiese, C.4    Gliksman, N.R.5    Walczak, C.E.6    Zheng, Y.7
  • 36
    • 0032476724 scopus 로고    scopus 로고
    • Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein and dynein
    • Wittmann, T., Boleti, H., Antony, C., Karsenti, E. and Vernos, I. (1998) Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein and dynein. J. Cell Biol., 143, 673-685.
    • (1998) J. Cell Biol. , vol.143 , pp. 673-685
    • Wittmann, T.1    Boleti, H.2    Antony, C.3    Karsenti, E.4    Vernos, I.5
  • 37
    • 0034717818 scopus 로고    scopus 로고
    • TPX2, a novel Xenopus MAP involved in spindle pole organization
    • Wittmann, T., Wilm, M., Karsenti, E. and Vemos, I. (2000) TPX2, a novel Xenopus MAP involved in spindle pole organization. J. Cell Biol., 149, 1405-1418.
    • (2000) J. Cell Biol. , vol.149 , pp. 1405-1418
    • Wittmann, T.1    Wilm, M.2    Karsenti, E.3    Vemos, I.4
  • 38
    • 0035146128 scopus 로고    scopus 로고
    • The spindle: A dynamic assembly of microtubules and motors
    • Wittmann, T., Hyman, A. and Desai, A. (2001) The spindle: a dynamic assembly of microtubules and motors. Nat. Cell Biol., 3, E28-E34.
    • (2001) Nat. Cell Biol. , vol.3
    • Wittmann, T.1    Hyman, A.2    Desai, A.3
  • 39
    • 0032814745 scopus 로고    scopus 로고
    • Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts
    • Zhang, C., Hughes, M. and Clarke, P.R. (1999) Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts. J. Cell Sci., 112, 2453-2461
    • (1999) J. Cell Sci. , vol.112 , pp. 2453-2461
    • Zhang, C.1    Hughes, M.2    Clarke, P.R.3


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