A multilevel analysis of cognitive dysfunction and psychopathology associated with chromosome 22q11.2 deletion syndrome in children

Development and Psychopathology

Volumn 17, Issue 3, 2005, Pages 753-784

  Simon, Tony J ^a   Bish, Joel P ^b   Bearden, Carrie E ^c   Ding, Lijun ^b   Ferrante, Samantha ^b   Nguyen, Vy ^a   Gee, James C ^d   McDonald McGinn, Donna M ^b   Zackai, Elaine H ^b,d   Emanuel, Beverly S ^b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ARTICLE; ASSOCIATION; ATTENTION; ATTENTION DEFICIT DISORDER; AUTISM; BRAIN DEVELOPMENT; BRAIN FUNCTION; BRAIN MALFORMATION; BRAIN MAPPING; BRAIN TISSUE; CHILD; CHILD BEHAVIOR; CHROMOSOME 22Q; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CHROMOSOME DELETION 22; COGNITION; COGNITIVE DEFECT; CORPUS CALLOSUM; DEPTH PERCEPTION; DISEASE ASSOCIATION; FRONTAL LOBE; GENE EXPRESSION REGULATION; GENETIC VARIABILITY; HEREDITY; HUMAN; INCIDENCE; MENTAL DISEASE; MENTAL HEALTH; NERVE CELL NETWORK; NUMERICAL CHROMOSOME ABERRATION; PARIETAL LOBE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RISK FACTOR; SCHIZOPHRENIA; STRUCTURE ACTIVITY RELATION;

ATTENTION; BRAIN; CHILD; CHROMOSOMES, HUMAN, PAIR 22; COGNITION DISORDERS; CUES; GENE DELETION; HUMANS; MENTAL DISORDERS; SPACE PERCEPTION; VISUAL PERCEPTION;

EID: 33645921626     PISSN: 09545794     EISSN: 14692198     Source Type: Journal    
DOI: 10.1017/S0954579405050364     Document Type: Article

References (126)

1. Akhtar, N., & Enns, J. T. (1989). Relations between covert orienting and filtering in the development of visual attention. Journal of Experimental Child Psychology, 48, 315-334.
2. Akshoomoff, N. A., & Courchesne, E. (1994). ERP evidence for a shifting attention deficit in patients with damage to the cerebellum. Journal of Cognitive Neuroscience, 6, 388-399.
3. Allen, G., Buxton, R. B., Wong, E. C., & Courchesne, E. (1997). Attentional activation of the cerebellum independent of motor involvement. Science, 275, 1940-1943.
4. Arnold, P. D., Siegel-Bartelt, J., Cytrynbaum, C., Teshima, I., & Schachar, R. (2001). Velo-cardio-facial syndrome: Implications of microdeletion 22q11 for schizophrenia and mood disorders. American Journal of Medical Genetics, 105, 354-362.
5. Ashburner, J., & Friston, K. J. (2000). Voxel-based morphometry - The methods. NeuroImage, 11, 805-821.
6. Barnea-Goraly, N., Menon, V., Krasnow, B., Ko, A., Reiss, A. L., & Eliez, S. (2003). Investigation of white matter structure in velocardiofacial syndrome: A diffusion tensor imaging study. American Journal of Psychiatry, 160, 1863-1869.
7. Basset, P. J., & Pierpaoli, C. (1996). Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. Journal of Magnetic Resonance, Series B, 111, 209-219.
8. Bassett, A. S., & Chow, E. W. (1999). 22q11 deletion syndrome: A genetic subtype of schizophrenia. Biological Psychiatry, 46, 882-891.
9. Bassett, A. S., Hodgkinson, K., Chow, E. W., Correia, S., Scutt, L. E., & Weksberg, R. (1998). 22q11 deletion syndrome in adults with schizophrenia. American Journal of Medical Genetics, 81, 328-337.
10. Bayley, N. (1969). Bayley Infant Scales of Infant Development. New York: Psychological Corporation.
11. Bearden, C. E., Jawad, A. F., Lynch, D. R., Monterosso, J. R., Sokol, S. M., McDonald-McGinn, D., Saitta, S. C., Harris, S. E., Moss, E. M., Wang, P. P., Zackai, E., Emannuel, B. S., & Simon, T. J. (in press). Effects of COMT genotype on behavioral symptomatology in the 22q11.2 Deletion Syndrome. Child Neuropsychology.
12. Bearden, C. E., Jawad, A. F., Lynch, D. R., Sokol, S. M., Kanes, S. J., McDonald-McGinn, D., Saitta, S. C., Harris, S. E., Moss, E. M., Wang, P. P., Zackai, E., Emannuel, B. S., & Simon, T. J. (2004). Effects of a functional COMT polymorphism on prefrontal cognitive function in the 22q11.2 deletion syndrome. American Journal of Psychiatry, 161, 1700-1702.
13. Bearden, C. E., Woodin, M. F., Wang, P. P., Moss, E., McDonald-McGinn, D., Zackai, E., Emannuel, B., & Cannon, T. D. (2001). The neurocognitive phenotype of the 22q11.2 deletion syndrome: Selective deficit in visual-spatial memory. Journal of Clinical and Experimental Neuropsychology, 23, 447-464.
14. Belmonte, M. K., & Yurgelun-Todd, D. A. (2003). Functional anatomy of impaired selective attention and compensatory processing in autism. Cognitive Brain Research, 17, 651-664.
15. Bilder, R. M., Volavka, J., Czobor, P., Malhotra, A. K., Kennedy, J. L., Ni, X., Goldman, R. S., Hoptman, M. J., Sheitman, B., Lindenmayer, J. P., Citrome, L., McEvoy, J. P., Kunz, M., Chakos, M., Cooper, T. B., & Lieberman, J. A. (2002). Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia. Biological Psychiatry, 52, 701-707.
16. Bish, J. P., Ferrante, S., McDonald-McGinn, D., Zackai, E., & Simon, T. J. (2005). Maladaptive conflict monitoring as evidence for executive dysfunction in children with chromosome 22q11.2 deletion syndrome. Developmental Science, 8, 36-43.
17. Bish, J. P., Nguyen, V., Ding, L., Ferrante, S., & Simon, T. J. (2004). Thalamic reductions in children with chromosome 22q11.2 deletion syndrome. NeuroReport, 15, 1413-1415.
18. Booth, J. R., Burman, D. D., Meyer, J. R., Lei, Z., Trommer, B. L., Davenport, N. D., Li, W., Parrish, T. B., Gitelman, D. R., & Mesulam, M. M. (2003). Neural development of selective attention and response inhibition. NeuroImage, 20, 737-751.
19. Botvinick, M., Nystrom, L. E., Fissell, K., Carter, C. S., & Cohen, J. D. (1999). Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature, 402 (6758), 179-181.
20. Bunge, S. A., Dudukovic, N. M., Thomason, M. E., Vaidya, C. J., & Gabrieli, J. D. (2002). Immature frontal lobe contributions to cognitive control in children: Evidence from fMRI. Neuron, 33, 301-311.
21. Bunge, S. A., Hazeltine, E., Scanlon, M. D., Rosen, A. C., & Gabrieli, J. D. (2002). Dissociable contributions of prefrontal and parietal cortices to response selection. NeuroImage, 17, 1562-1571.
22. Burn, J., & Goodship, J. (1996). Developmental genetics of the heart. Current Opinion in Genetics and Development, 6, 322-325.
23. Burn, J., Takao, A., Wilson, D., Cross, I., Momma, K., Wadey, R., Scambler, P., & Goodship, J. (1993). Conotruncal anomaly face syndrome is associated with a deletion within chromosome 22. Journal of Medical Genetics, 30, 822-824.
24. Bush, G., Luu, P., & Posner, M. I. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences, 4, 215-222.
25. Byne, W., Buchsbaum, M. S., Kemether, E., Hazlett, E. A., Shinwari, A., Mitropoulou, V., & Siever, L. J. (2001). Magnetic resonance imaging of the thalamic mediodorsal nucleus and pulvinar in schizophrenia and schizotypal personality disorder. Archives of General Psychiatry, 58, 133-140.
26. Casey, B. J., Thomas, K. M., Welsh, T. F., Badgaiyan, R., Eccard, C. H., Jennings, J. R., & Crone, E. A. (2000). Dissociation of response conflict, attentional control, and expectancy with functional magnetic resonance imaging (fMRI). Proceedings of the National Academy of Sciences of the United States of America, 97, 8728-8733.
27. Cicchetti, D., & Dawson, G. (2002). Multiple levels of analysis. Development and Psychopathology, 14, 417-420.
28. Corbetta, M. (1998). Frontoparietal cortical networks for directing attention and the eye to visual locations: Identical, independent or overlapping neural systems? Proceedings of the National Academy of Sciences of the United States of America, 95, 831-838.
29. Corbetta, M., & Shulman, G. L. (2002). Control of goal-directed and stimulus-driven attention in the brain. Nature Reviews: Neuroscience, 3, 201-215.
30. Courchesne, E., Townsend, J., Akshoomoff, N. A., Saitoh, O., Yeung-Courchesne, R., Lincoln, A. J., James, H. E., Haas, R. H., Schreibman, L., & Lau, L. (1994). Impairment in shifting attention in autistic and cerebellar patients. Behavioral Neuroscience, 108, 848-865.
31. Culham, J. C., Cavanaugh, P., & Kanwisher, N. G. (2001). Attention response functions: Characterizing brain areas using fMRI activation during parametric variations of attentional load. Neuron, 32, 737-745.
32. Davidson, L. L., & Heinrichs, R. W. (2003). Quantification of frontal and temporal lobe brain-imaging findings in schizophrenia: A meta-analysis. Psychiatry Research, 122, 69-87.
33. Dehaene, S., & Cohen, L. (1995). Towards an anatomical and functional model of number processing. Mathematical Cognition, 1, 83-120.
34. Dehaene, S., Piazza, M., Pinel, P., & Cohen, L. (2003). Three parietal circuits for number processing. Cognitive Neuropsychology, 20, 487-506.
35. Dehaene, S., Spelke, E. S., Pinel, P., Stanescu, R., & Tsivkin, S. (1999). Sources of mathematical thinking: Behavioral and brain imaging evidence. Science, 284, 970-974.
36. DiGeorge, A. (1965). A new concept of the cellular basis of immunity. Journal of Pediatrics, 67, 907.
37. Driscoll, D. A., Budarf, M. L., & Emanuel, B. S. (1992). Consistent deletions and microdeletions of 22q11. American Journal of Human Genetics, 50, 924-933.
38. Driscoll, D. A., Spinner, N. B., Budarf, M. L., McDonald-McGinn, D. M., Zackai, E. H., Goldberg, R. B., Shprintzen, R. J., Saal, H. M., Zonana, J., Jones, M. C., Mascarello, J. T., & Emanuel, B. S. (1992). Deletions and microdeletions of 22q11.2 in velo-cardio-facial syndrome. American Journal of Human Genetics, 44, 261-268.
39. Durston, S. (2003). A review of the biological bases of ADHD: What have we learned from imaging studies? Mental Retardation and Developmental Disabilities Research Reviews, 9, 184-195.
40. Durston, S., Thomas, K. M., Yang, Y., Ulug, A. M., Zimmerman, R. D., & Casey, B. J. (2002). A neural basis for the development of inhibitory control. Developmental Science, F9-F16.
41. Durston, S., Tottenham, N. T., Thomas, K. M., Davidson, M. C., Eigsti, I. M., Yang, Y., Ulug, A. M., & Casey, B. J. (2003). Differential patterns of striatal activation in young children with and without ADHD. Biological Psychiatry, 53, 871-878.
42. Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. H., Straub, R. E., Goldman, D., & Weinberger, D. R. (2001). Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 98, 6917-6922.
43. Eliez, S., Blasey, C. M., Menon, V., White, C. D., Schmitt, J. E., & Reiss, A. L. (2001). Functional brain imaging study of mathematical reasoning abilities in velocardiofacial syndrome (del22q11.2). Genetics in Medicine, 3, 49-55.
44. Eliez, S., Blasey, C. M., Schmitt, E. J., White, C. D., Hu, D., & Reiss, A. L. (2001). Velocardiofacial syndrome: Are structural changes in the temporal and mesial temporal regions related to schizophrenia. American Journal of Psychiatry, 158, 447-453.
45. Eliez, S., Schmitt, J. E., White, C. D., & Reiss, A. L. (2000). Children and adolescents with velocardiofacial syndrome: A volumetric study. American Journal of Psychiatry, 157, 409-415.
46. Emanuel, B. S., McDonald-McGinn, D., Saitta, S. C., & Zackai, E. H. (2001). The 22q11.2 deletion syndrome. Advances in Pediatrics, 48, 39-73.
47. Eriksen, B. A., & Eriksen, C. W. (1974). Effects of noise letters upon the identification of a target letter in a nonsearch task. Perception & Psychophysics, 16, 143-149.
48. Feinstein, C., Eliez, S., Blasey, C., & Reiss, A. L. (2002). Psychiatric disorders and behavioral problems in children with velocardiofacial syndrome: Usefulness as phenotypic indicators of schizophrenia risk. Biological Psychiatry, 51, 312-318.
49. Fine, S., Weissman, A., Gerdes, M., Pinto-Martin, J., Zackai, E., McDonald-McGinn, D., & Emanuel, B. S. (2005). Autism spectrum disorders and symptoms in children with moloecularly confirmed 22q11.2 deletion syndrome. Journal of Autism and Developmental Disorders, 35, 461-470.
50. Fletcher, J. M., Bohan, T. P., Brandt, M. E., Brookshire, B. L., Beaver, S. R., Francis, D. J., Davidson, K. C., Thompson, N. M., & Miner, M. E. (1992). Cerebral white matter and cognition in hydrocephalic children. Archives of Neurology, 49, 818-824.
51. Fossella, J., Sommer, T., Fan, J., Wu, Y., Swanson, J. M., Pfaff, D. W., & Posner, M. I. (2002). Assessing the molecular genetics of attention networks. BMC Neuroscience, 3, 14.
52. Gerdes, M., Solot, C. B., Wang, P. P., Moss, E. M., LaRossa, D., Randall, P., Goldmuntz, E., Clark, B. J., Driscoll, D. A., Jawad, A., Emmanuel, B. S., McDonald-McGinn, D. M., Batshaw, M. L., & Zackai, E. H. (1999). Cognitive and behavior profile of preschool children with chromosome 22q11.2 deletion. American Journal of Medical Genetics, 85, 127-133.
53. Giannotti, A., Digilio, M. C., Marino, B., Mingarelli, R., & Dallapiccola, B. (1994). Cayler cardiofacial syndrome and del 22q11: Part of the CATCH22 phenotype. American Journal of Medical Genetics, 53, 303-304.
54. Glatt, S. J., Faraone, S. V., & Tsuang, M. T. (2003). Association between a functional catechol-O-methyltransferase gene polymorphism and schizophrenia: Meta-analysis of case-control and family-based studies. American Journal of Psychiatry, 160, 469-476.
55. Göbel, S., Walsh, V., & Rushworth, M. F. S. (2001). The mental number line and the human angular gyrus. NeuroImage, 14, 1278-1289.
56. Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., & Heintz, N. (2003). A gene expression atlas of the central nervous system based on bacterial artificial chromosomes. Nature, 425(6961), 917-925.
57. Gothelf, D., Presburger, G., Zohar, A. H., Burg, M., Nahmani, A., Frydman, M., Shohat, M., Inbar, D., Aviram-Goldring, A., Yeshaya, J., Steinberg, T., Finkelstein, Y., Frisch, A., Weizman, A., & Apter, A. (2004). Obsessive-compulsive disorder in patients with velocardiofacial (22q11 deletion) syndrome. American Journal of Medical Genetics, 126B, 99-105.
58. Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160, 636-645.
59. Graf, W. D., Unis, A. S., Yates, C. M., Sulzbacher, S., Dinulos, M. B., Jack, R. M., Dugaw, K. A., Paddock, M. N., & Parson, W. W. (2001). Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism. Neurology, 57, 410-416.
60. Gratton, G., Coles, M. G. H., & Donchin, E. (1992). Optimizing the use of information: Strategic control of activation of responses. Journal of Experimental Psychology: General, 121, 480-506.
61. Greenwood, P. M., & Parasuraman, R. (2003). Normal genetic variation, cognition and aging. Behavioral and Cognitive Neuroscience Reviews, 2, 278-306.
62. Greenwood, P. M., Sunderland, T., Friz, J. L., & Parasuraman, R. (2000). Genetics and visual attention: Selective deficits in healthy adult carriers of the epsilon 4 allele of the apolipoprotein E gene. Proceedings of the National Academy of Sciences of the United States of America, 97, 11661-11666.
63. Grossman, M. H., Emanuel, B. S., & Budarf, M. L. (1992). Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1-q11.2. Genomics, 12, 822-825.
64. Henry, J. C., van Amelsvoort, T., Morris, R. G., Owen, M. J., Murphy, D. G., & Murphy, K. C. (2002). An investigation of the neuropsychological profile in adults with velo-cardio-facial syndrome (VCFS). Neuropsychologia, 40, 471-478.
65. Johnson, M. H., Halit, H., Grice, S. J., & Karmiloff-Smith, A. (2002). Neuroimaging of typical and atypical development: A perspective from multiple levels of analysis. Developments in Psychopathology, 14, 521-536.
66. Karayiorgou, M., Morris, M. A., Morrow, B., Shprintzen, R. J., Goldberg, R., Borrow, J., Gos, A., Nestadt, G., Wolyniec, P. S., Lasseter, V. K., Eisen, H., Childs, B., Kazazian, H. H., Kucherlapati, R., Antonarakis, S. E., & Housman, D. E. (1995). Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proceedings of the National Academy of Sciences of the United Sates of America, 92, 7612-7616.
67. Kates, W. R., Burnette, C. P., Jabs, E. W., Rutberg, J., Murphy, A. M., Grados, M., Geraghty, M., Kaufmann, W. E., & Pearlson, G. D. (2001). Regional cortical white matter reductions in velocardiofacial syndrome: A volumetric MRI analysis. Biological Psychiatry, 49, 677-684.
68. Kerns, J. G., Cohen, J. D., MacDonald, A. W., 3rd, Cho, R. Y., Stenger, V. A., & Carter, C. S. (2004). Anterior cingulate conflict monitoring and adjustments in control. Science, 303 (5660), 1023-1026.
69. Kingstone, A., Friesen, C. K., & Gazzaniga, M. S. (2000). Reflexive joint attention depends in lateralized cortical connections. Psychological Science, 11, 159-166.
70. Kingstone, A., Grabowecky, M., Mangun, G. R., Valsangkar, M. A., & Gazzaniga, M. S. (1997). Paying attention to the brain. The study of selective visual attention in cognitive neuroscience. In J. Burak & J. T. Enns (Eds.), Attention, development, and psychopathology. New York: Guilford Press.
71. Lachman, H. M., Kelsoe, J. R., Remick, R. A., Sadovnick, A. D., Rapaport, M. H., Lin, M., Pazur, B. A., Roe, A. M., Saito, T., & Papolos, D. F. (1997). Linkage studies suggest a possible locus for bipolar disorder near the velo-cardio-facial syndrome region on chromosome 22. American Journal of Medical Genetics, 74, 121-128.
72. Lachman, H. M., Papolos, D. F., Saito, T., Yu, Y. M., Szumlanski, C. L., & Weinshilboum, R. M. (1996). Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics, 6, 243-250.
73. Landry, R., & Bryson, S. E. (2004). Impaired disengagement of attention in young children with autism. Journal of Child Psychology and Psychiatry, 45, 1115-1122.
74. Liu, H., Heath, S. C., Sobin, C., Roos, J. L., Galke, B. L., Blundell, M. L., Lenane, M., Robertson, B., Wijsman, E. M., Rapoport, J. L., Gogos, J. A., & Karayiorgou, M. (2002). Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 99, 3717-3722.
75. Luck, S. J., Hillyard, S. A., Mangun, G. R., & Gazzaniga, M. S. (1989). Independent hemispheric attentional systems mediate visual search in split-brain patients. Nature, 342, 543-545.
76. Malhotra, A. K., Kestler, L. J., Mazzanti, C., Bates, J. A., Goldberg, T., & Goldman, D. (2002). A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. American Journal of Psychiatry, 159, 652-654.
77. Mataro, M., Poca, M. A., Sahuquillo, J., Cuxart, A., Iborra, J., de la Calzada, M. D., & Junque, C. (2000). Cognitive changes after cerebrospinal fluid shunting in young adults with spina bifida and assumed arrested hydrocephalus. Journal of Neurology, Neurosurgery, and Psychiatry, 68, 615-621.
78. Maynard, T. M., Haskell, G. T., Peters, A. Z., Sikich, L., Lieberman, J. A., & LaMantia, A. S. (2003). A comprehensive analysis of 22q11 gene expression in the developing and adult brain. Proceedings of the National Academy of Sciences of the United States of America, 100, 14433-14438.
79. McDonald-McGinn, D. M., Driscoll, D. A., Bason, L., Christensen, K., Lynch, D., Sullivan, K., Canning, D., Zavod, W., Quinn, N., & Rome, J. (1995). Autosomal dominant "Opitz" GBBB syndrome due to a 22q11.2 deletion. American Journal of Medical Genetics, 59, 103-113.
80. McDonald-McGinn, D. M., Kirschner, R., Goldmuntz, E., Sullivan, K., Eicher, P., Gerdes, M., Moss, E. M., Solot, C. B., Wang, P. P., Jacobs, I., Handler, S., Knightly, C., Heher, K., Wilson, M., Ming, J. E., Grace, K., Driscoll, D. A., Pasquariello, P., Randall, P., LaRossa, D., Emanuel, B. S., & Zackai, E. H. (1999). The Philadelphia Story: The 22q11.2 deletion: Report on 250 patients. Genetic Counselling, 10, 11-24.
81. Mesulam, M. M., Nobre, A. C., Kim, Y.-H., Parrish, T. B., & Gitelman, D. R. (2001). Heterogeneity of cingulate contributions to spatial attention. NeuroImage, 13, 1055-1072.
82. Moss, E. M., Batshaw, M. L., Solot, C. B., Gerdes, M., McDonald-McGinn, D. M., Driscoll, D. A., Emmanuel, B. S., Zackai, E. H., & Wang, P. P. (1999). Psychoeducational profile of the 22q11.2 microdeletion: A complex pattern. The Journal of Pediatrics, 134, 193-198.
83. Murphy, K. C., Jones, L. A., & Owen, M. J. (1999). High rates of schizophrenia in adults with velo-cardio-facial syndrome. Archives of General Psychiatry, 56, 940-945.
84. Nieoullon, A. (2002). Dopamine and the regulation of cognition and attention. Progress in Neurobiology, 67, 53-83.
85. Niklasson, L., Rasmussen, P., Oskarsdottir, S., & Gillberg, C. (2001). Neuropsychiatric disorders in the 22q11 deletion syndrome. Genetics in Medicine, 3, 79-84.
86. Niklasson, L., Rasmussen, P., Oskarsdottir, S., & Gillberg, C. (2002). Chromosome 22q11 deletion syndrome (CATCH 22): Neuropsychiatric and neuropsychological aspects. Developmental Medicine and Child Neurology, 44, 44-50.
87. Papolos, D. F., Faedda, G. L., Veit, S., Goldberg, R., Morrow, B., Kucherlapati, R., & Shprintzen, R. J. (1996). Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: Does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder? American Journal of Psychiatry, 153, 1541-1547.
88. Parasuraman, R., & Greenwood, P. M. (2004). Molecular genetics of visuospatial attention and working memory. In M. I. Posner (Ed.), Cognitive neuroscience of attention. New York: Guilford Press.
89. Pesenti, M., Thioux, M., Seron, X., & De Volder, A. (2000). Neuroanatomical substrates of arabic number processing, numerical comparison and simple addition: A PET study. Journal of Cognitive Neuroscience, 12, 461-479.
90. Petersen, S. E., Robinson, D. L., & Morris, J. D. (1987a). Contributions of the pulvinar to visual spatial attention. Neuropsychologia, 25, 97-105.
91. Petersen, S. E., Robinson, D. L., & Morris, J. D. (1987b). Contributions of the pulvinar to visual spatial attention. Neuropsychologia, 25(1A), 97-105.
92. Piazza, M., Giacomini, E., Le Bihan, D., & Dehaene, S. (2003). Single trial classification of parallel preattentive and serial attentive processing using functional magnetic resonance imaging. Proceedings of the Royal Society of London, Series B: Biological Sciences,, 1237-1245.
93. Piazza, M., Mechelli, A., Butterworth, B., & Price, C. J. (2002). Are subitizing and counting implemented as separate or functionally overlapping processes? NeuroImage, 15, 435-446.
94. Pierpaoli, C., & Basser, P. J. (1996). Toward a quantitative assessment of diffusion anisotropy. Magnetic Resonance in Medicine, 36, 893-906.
95. Pinel, P., Le Clec'H, G., van de Moortele, P., Naccache, L., Le Bihan, D., & Dehaene, S. (1999). Event-related fMRI analysis of the cerebral circuit for number comparison. NeuroReport, 10(7), 1473-1479.
96. Posner, M. I. (1980). Orienting of attention. Quarterly Journal of Experimental Psychology, 32, 3-25.
97. Posner, M. I., & Petersen, S. E. (1990). The attention system of the human brain. Annual Review of Neuroscience, 13, 25-42.
98. Posner, M. I., Walker, J. A., Friedrich, F. J., & Rafal, R. D. (1984). Effects of parietal injury on covert orienting of attention. The Journal of Neuroscience, 4, 1863-1874.
99. Purcell, R., Maruff, P., Kyrios, M., & Pantelis, C. (1998). Cognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal function. Biological Psychiatry, 43, 348-357.
100. Rourke, B. P., Ahmad, S. A., Collins, D. W., Hayman-Abello, B. A., Hayman-Abello, S. E., & Warriner, E. M. (2002). Child clinical/pediatric neuropsychology: Some recent advances. Annual Review of Psychology, 53, 309-339.
101. Rueda, M. R., Fan, J., McCandliss, B. D., Halparin, J. D., Gruber, D. B., Lercari, L. P., & Posner, M. I. (2004). Development of attentional networks in childhood. Neuropsychologia, 42, 1029-1040.
102. Sathian, K., Simon, T. J., Peterson, S., Patel, G. A., Hoffman, J. M., & Grafton, S. T. (1999). Neural evidence linking visual object enumeration and attention. Journal of Cognitive Neuroscience, 11(1), 36-51.
103. Shashi, V., Muddasani, S., Santos, C. C., Berry, M. N., Kwapil, T. R., Lewandowski, E., & Keshavan, M. S. (2004). Abnormalities of the corpus callosum in non-psychotic children with chromosome 22q11 deletion syndrome. NeuroImage, 21, 1399-1406.
104. Shprintzen, R. J., Goldberg, R. B., Lewin, M. L., Sidoti, E. J., Berkman, M. D., Argamaso, R. V., & Young, D. (1978). A new syndrome involving cleft palate, cardiac anomalies, typical faces, and learning disabilities: Velo-cardio-facial syndrome. Cleft Palate Journal, 15, 56-62.
105. Simon, T. J. (1997). Reconceptualizing the origins of number knowledge: A "non-numerical" approach. Cognitive Development, 12, 349-372.
106. Simon, T. J., Bearden, C. E., McDonald-McGinn, D. M., & Zackai, E. H. (2005). Visuospatial and numerical cognitive deficits in chromosome 22q11.2 deletion syndrome. Cortex, 41, 131-141.
107. Simon, T. J., Ding, L., Bish, J. P., McDonald-McGinn, D. M., Zackai, E. H., & Gee, J. C. (2005). Volumetric, connective and morphologic changes in the brains of children with chromosome 22q11.2 deletion syndrome: An integrative study. NeuroImage, 25, 169-180.
108. Sobin, C., Kiley-Brabeck, K., Daniels, S., Blundell, M., Anyane-Yeboa, K., & Karayiorgou, M. (2004). Networks of attention in children with the 22q11 deletion syndrome. Developmental Neuropsychology, 26, 611-626.
109. Swanson, J., Posner, M., Fosella, J., Wasdell, M., Sommer, T., & Fan, J. (2001). Genes and attention deficit hyperactivity disorder. Current Psychiatry Reports, 3, 92-100.
110. Swillen, A., Devriendt, K., Legius, E., Eyskens, B., Dumoulin, M., Gewillig, M., & Fryns, J. P. (1997). Intelligence and psychosocial adjustment in velocardiofacial syndrome: A study of 37 children and adolescents with VCFS. The Journal of Medical Genetics, 34, 453-458.
111. Swillen, A., Devriendt, K., Legius, E., Prinzie, P., Vogels, A., Ghesquiere, P., & Fryns, J. P. (1999). The behavioural phenotype in velo-cardio-facial syndrome (VCFS): From infancy to adolescence. Genetic Counselling, 10, 79-88.
112. Swillen, A., Vogels, A., Devriendt, K., & Fryns, J. P. (2000). Chromosome 22q11 deletion syndrome: Update and review of the clinical features, cognitive-behavioral spectrum, and psychiatric complications. American Journal of Medical Genetics, 97, 128-135.
113. Temple, E., & Posner, M. I. P. (1998). Brain mechanisms of quantity are similar in 5-year-old children and adults. Proceedings of the National Academy of Sciences of the United States of America, 95, 7836-7841.
114. Townsend, J., Courchesne, E., Covington, J., Westerfield, M., Harris, N. S., Lyden, P., Lowry, T. P., & Press, G. A. (1999). Spatial attention deficits in patients with acquired or developmental cerebellar abnormality. Journal of Neuroscience, 19(13), 5632-5643.
115. Townsend, J. T., & Ashby, F. G. (1983). Stochastic modeling of elementary psychological processes. New York: Cambridge University Press.
116. Trick, L. M., & Pylyshyn, Z. W. (1993). What enumeration studies can tell us about spatial attention. Evidence for limited capacity preattentive processing. Journal of Experimental Psychology: Human Perception and Performance, 19, 331-351.
117. Trick, L. M., & Pylyshyn, Z. W. (1994). Why are small and large numbers enumerated differently? A limited capacity preattentive stage in vision. Psychological Review, 101, 80-102.
118. Vaidya, C. J., Austin, G., Kirkorian, G., Ridlehuber, H. W., Desmond, J. E., Glover, G. H., & Gabrieli, J. D. (1998). Selective effects of methylphenidate in attention deficit hyperactivity disorder: A functional magnetic resonance study. Proceedings of the National Academy of Sciences of the United States of America, 95, 4494-14499.
119. Van Amelsvoort, T., Daly, E., Robertson, D., Suckling, J., Ng, V., Critchley, H., Owen, M. J., Henry, J., Murphy, K. C., & Murphy, D. G. M. (2001). Structural brain abnormalities associated with the deletion at chromosome 22q11. British Journal of Psychiatry, 178, 412-419.
120. van Veen, V., & Carter, C. S. (2002). The anterior cingulate as a conflict monitor: FMRI and ERP studies. Physiology & Behavior, 77, 477-482.
121. Velakoulis, D., & Pantelis, C. (1996). What have we learned from functional imaging studies in schizophrenia? The role of frontal, striatal and temporal areas. The Australian and New Zealand Journal of Psychiatry, 30, 195-209.
122. Wang, P. P., Woodin, M. F., Kreps-Falk, R., & Moss, E. M. (2000). Research on behavioral phenotypes: Velocardiofacial syndrome (deletion 22q11.2). Developmental Medicine and Child Neurology, 42, 422-427.
123. Ward, R., Danziger, S., Owen, V., & Rafal, R. D. (2002). Deficits in spatial coding and feature binding following damage to the spatiotopic maps in the human pulvinar. Nature Neuroscience, 5, 99-100.
124. Woodin, M. F., Wang, P. P., Aleman, D., McDonald-McGinn, D. M., Zackai, E. H., & Moss, E. M. (2001). Neuropsychological profile of children and adolescents with the 22q11.2 microdeletion. Genetics in Medicine, 3, 34-39.
125. Woods, C. G. (2004). Human microcephaly. Current Opinion in Neurobiology, 14, 1-6.
126. Zakzanis, K. K., & Heinrichs, R. W. (1999). Schizophrenia and the frontal brain: A quantitative review. Journal of the International Neuropsychological Society, 5, 556-566.