CD5+ B cells are preferentially expanded in rabbit appendix: The role of CD5 in B cell development and selection

Developmental and Comparative Immunology

Volumn 30, Issue 8, 2006, Pages 711-722

  Pospisil, Richard ^a   Alexander, Cornelius B ^a   Obiakor, Harold ^a   Sinha, Rajesh K ^a   Mage, Rose G ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

appendix; B cells; CD5; gene conversion; rabbit; superantigens; trafficking; VH mutant ali ali

Indexed keywords

CD5 ANTIGEN; PADGEM PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APPENDIX; ARTICLE; B LYMPHOCYTE; BIRTH; BONE MARROW; CELL MATURATION; CELL MIGRATION; CELL MUTANT; CELL SELECTION; CONTROLLED STUDY; GENE CONVERSION; GENE REARRANGEMENT; GERMINAL CENTER; MUTATION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33645883256     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dci.2005.10.001     Document Type: Article

References (39)

1. Raman C., and Knight K.L. CD5+ B cells predominate in peripheral tissues of rabbit. J Immunol 149 (1992) 3858-3864
2. Pospisil R., Fitts M.G., and Mage R.G. CD5 is a potential selecting ligand for B-cell surface immunoglobulin framework region sequences. J Exp Med 184 (1996) 1279-1284
3. Knight K.L., and Crane M.A. Generating the antibody repertoire in rabbit. Adv Immunol 56 (1994) 179-218
4. Pospisil R., and Mage R.G. Rabbit appendix-A site of development and selection of the B-cell repertoire. In: Kelsoe G., and Flajnik M. (Eds). Contemporary topics in microbiology and immunology "somatic diversification of the immune response" (1998), Springer, Heidelberg 59-70
5. Dasso J.F., Obiakor H., Bach H., Anderson A.O., and Mage R.G. A morphological and immunohistological study of the human and rabbit appendix for comparison with the avian bursa. Dev Comp Immunol 24 (2000) 797-814
6. Sehgal D., Obiakor H., and Mage R.G. Distinct clonal Ig diversification patterns in young appendix compared to antigen-specific splenic clones. J Immunol 168 (2002) 5424-5433
7. Mehr R., Edelman H., Sehgal D., and Mage R.G. Analysis of mutational lineage trees from sites of primary and secondary Ig gene diversification in rabbits and chickens. J Immunol 172 (2004) 4790-4796
8. Knight K.L., and Becker R.S. Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: implications for the generation of antibody diversity. Cell 60 (1990) 963-970
9. Allegrucci M., Newman B.A., Young-Cooper G.O., Alexander C.B., Meier D., Kelus A.S., et al. Altered phenotypic expression of immunoglobulin heavy-chain variable-region (VH) genes in Alicia rabbits probably reflects a small deletion in the VH genes closest to the joining region. Proc Natl Acad Sci USA 87 (1990) 5444-5448
10. Allegrucci M., Young-Cooper G.O., Alexander C.B., Newman B.A., and Mage R.G. Preferential rearrangement in normal rabbits of the 3′ VHa allotype gene that is deleted in Alicia mutants; somatic hypermutation/conversion may play a major role in generating the heterogeneity of rabbit heavy chain variable region sequences. Eur J Immunol 21 (1991) 411-417
11. Ros F., Puels J., Reichenberger N., van Schooten W., Buelow R., and Platzer J. Sequence analysis of 0.5 Mb of the rabbit germline immunoglobulin heavy chain locus. Gene 330 (2004) 49-59
12. DiPietro L.A., Short J.A., Zhai S.K., Kelus A.S., Meier D., and Knight K.L. Limited number of immunoglobulin VH regions expressed in the mutant rabbit "Alicia". Eur J Immunol 20 (1990) 1401-1404
13. Chen H.T., Alexander C.B., Young-Cooper G.O., and Mage R.G. VH gene expression and regulation in the mutant Alicia rabbit. Rescue of VHa2 allotype expression. J Immunol 150 (1993) 2783-2793
14. H4 gene. J Immunol 160 (1998) 1246-1255
15. Chen H.T., Alexander C.B., and Mage R.G. Characterization of a rabbit germ-line VH gene that is a candidate donor for VH gene conversion in mutant Alicia rabbits. J Immunol 154 (1995) 6365-6371
16. Zhu X., Boonthum A., Zhai S.K., and Knight K.L. B lymphocyte selection and age-related changes in VH gene usage in mutant Alicia rabbits. J Immunol 163 (1999) 3313-3320
17. Pospisil R., Young-Cooper G.O., and Mage R.G. Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: "Positive" selection in appendix of normal and VH-mutant rabbits. Proc Natl Acad Sci 92 (1995) 6961-6965
18. Pospisil R., and Mage R.G. B-cell superantigens play a role in B-cell development and selection in the young rabbit appendix. Cell Immunol 185 (1998) 93-100
19. Rhee K.-J., Jasper P.J., Sethupathi P., Shanmugam M., Zhai S.-K., and Knight K.L. Positive selection of the peripheral B cell repertoire in gut-associated lymphoid tissues. J Exp Med 200 (2005) 55-62
20. Pospisil R., and Mage R.G. CD5 and other superantigens as "Ticklers" of the B cell receptor. Immunol Today 19 (1998) 106-108
21. Mage R.G., and Pospisil R. CD5 and other superantigens may select and maintain rabbit self-renewing B-lymphocytes and human B-CLL cells. Curr Top Microbiol Immunol 252 (2000) 87-96
22. Pospisil R., Obiakor H., Newman B., Alexander C., and Mage R.G. Stable expression of the extracellular domains of rabbit recombinant CD5: development and characterization of polyclonal and monoclonal antibodies. Vet Immunol Immunopathol 103 (2005) 257-267
23. Sinha R.K., and Mage R.G. Developing neonatal rabbit appendix, a primary lymphoid organ, is seeded by immature blood-borne B cells: evidence for roles for CD62L/PNAd, CCR7/CCL21, α4β1 and LFA-1. Dev Comp Immunol 28 (2004) 829-841
24. Lankester A.C., van Schijndel G.M.W., Cordell J.L., van Noesel C.J.M., and van Lier R.A.W. CD5 is associated with the human B cell antigen receptor complex. Eur J Immunol 24 (1994) 812-816
25. Gary-Gouy H., Bruhns P., Schmitt C., Dalloul A., Daeron M., and Bismuth G. The pseudo-immunoreceptor tyrosine-based activation motif of CD5 mediates its inhibitory action on B-cell receptor signaling. J Biol Chem 275 (2000) 548-556
26. Sato S., Ono N., Steeber D.A., Pisetsky D.S., and Tedder T.F. CD19 regulates B lymphocyte signaling thresholds critical for development of B-1 lineage cells in autoimmunity. J Immunol 157 (1996) 4371-4378
27. Lu X., Axtell R.C., Collawn J.F., Gibson A., Justement L.B., and Raman C. AP2 adaptor complex-dependent internalization of CD5: differential regulation in T and B cells. J Immunol 168 (2002) 5612-5620
28. Sehgal D., Schiaffella E., Anderson A.O., and Mage R.G. Analyses of single B cells by PCR reveals rearranged VH with germline sequences in spleens of immunized rabbits: implications for B cell repertoire maintenance and renewal. J Immunol 161 (1998) 5347-5356
29. Schiaffella E., Sehgal D., Anderson A.O., and Mage R.G. Gene conversion and hypermutation during diversification of VH sequences in developing splenic germinal centers of immunized rabbits. J Immunol 162 (1999) 3984-3995
30. Sehgal D., Schiaffella E., Anderson A.O., and Mage R.G. Generation of heterogeneous rabbit anti-DNP antibodies by gene conversion and hypermutation of rearranged VL and VH genes during clonal expansion of B cells in splenic germinal centers. Eur J Immunol 30 (2000) 3634-3644
31. +B cells control the IL-12-dependent Th1-priming capacity of neonatal DCs. Immunity 22 (2005) 467-477
32. Lam K.P., and Rajewsky K. B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development. J Exp Med 190 (1999) 471-478
33. Casola S., Otipoby K.L., Alimzhanov M., Humme S., Uyttersprot N., Kutok J.L., et al. B cell receptor signal strength determines B cell fate. Nat Immunol 5 (2004) 317-327
34. Mansikka A., Jalkanen S., Sandberg M., Granfors K., Lassila O., and Toivanen P. Bursectomy of chicken embryos at 60 hours of incubation leads to an oligoclonal B cell compartment and restricted Ig diversity. J Immunol 145 (1990) 3601-3609
35. Obiakor H., Sehgal D., Dasso J.F., Bonner R.F., Malekafzali A., and Mage R.G. A comparison of hydraulic and laser capture microdissection methods for recovery of rearranged immunoglobulin genes of single B lymphocytes, PCR and sequencing of antibody VDJ. Anal Biochem 306 (2002) 55-62
36. McHeyzer-Williams M.G., Nossal G.J., and Lalor P.A. Molecular characterization of single memory B cells. Nature 350 (1991) 502
37. Liu A.H., Creadon G., and Wysocki L.J. Sequencing heavy- and light-chain variable genes of single B-hybridoma cells by total enzymatic amplification. Proc Natl Acad Sci USA 89 (1992) 7610-7614
38. Jacob J., Przylepa J., Miller C., and Kelsoe G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J Exp Med 178 (1993) 1293-1307
39. Kabat E.A., Wu T.T., Perry H.M., Gottesman K.S., and Foeller C. Sequences of proteins of immunological interest. 5th ed. (1991), US Department of Health and Human Services, Washington, DC