Developing neonatal rabbit appendix, a primary lymphoid organ, is seeded by immature blood-borne B cells: Evidence for roles for CD62L/PNAd, CCR7/CCL21, α4β1 and LFA-1

Developmental and Comparative Immunology

Volumn 28, Issue 7-8, 2004, Pages 829-841

  Sinha, Rajesh K ^a   Mage, Rose G ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Adhesion molecules; B cell recruitment; Cell trafficking; Chemokines; FSC, forward scatter; GALT, gut associated lymphoid tissues; HEV, high endothelial venules; PI, propidium iodide; PNAd, peripheral lymph node addressin; Rabbit appendix; SSC, side scatter

Indexed keywords

ANIMAL CELL; APPENDIX; ARTICLE; B LYMPHOCYTE; BIRTH; BLOOD ANALYSIS; CELL MATURATION; CELL MIGRATION; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE CONVERSION; IMMUNOCHEMISTRY; LYMPHOID ORGAN; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; NEWBORN; NONHUMAN; ORGANOGENESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RABBIT; STRUCTURE ANALYSIS;

ANIMALIA; GALLUS GALLUS; ORYCTOLAGUS CUNICULUS;

EID: 1642358927     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dci.2004.01.003     Document Type: Article

References (47)

1. Cooper M.D., Perey D.Y., Gabrielsen R.A., Sutherland D.E.R., McKneally M.F., Good R.A. Production of an antibody deficiency syndrome in rabbits by neonatal removal of organized intestinal lymphoid tissues. Int Arch Allergy Appl Immunol. 33:1968;65-88.
2. Dasso J.F., Howell M.D. Neonatal appendectomy impairs mucosal immunity in rabbits. Cell Immunol. 182:1997;29-37.
3. Cooper M.D., Perey D.Y., McKneally M.F., Gabrielsen R.A., Sutherland D.E.R., Good R.A. A mammalian equivalent of the avian bursa fabricius. Lancet. 1:1966;1388-1391.
4. Weinstein P.D., Mage R.G., Anderson A.O. The appendix functions as a mammalian bursal equivalent in the developing rabbit. Adv Exp Med Bio1. 355:1994;249-253.
5. Weinstein P.D., Anderson A.O., Mage R.G. Rabbit IgH sequences in appendix germinal centers: VH diversification by gene conversion-like and hypermutation mechanisms. Immunity. 1:1994;647-659.
6. Vajdy M., Sethupathi P., Knight K.L. Dependence of antibody somatic diversification on gut-associated lymphoid tissue in rabbits. J Immunol. 160:1998;2725-2729.
7. Sehgal D., Obiakor H., Mage R.G. Distinct clonal Ig diversification patterns in young appendix compared to antigen-specific splenic clones. J Immunol. 168:2002;5424-5433.
8. Dasso J.F., Obiakor H., Bach H., Anderson A.O., Mage R.G. A morphological and immunohistological study of the human and rabbit appendix for comparison with the avian bursa. Dev Comp Immunol. 24:2000;797-814.
9. Kelus A.S., Weiss S. Mutation affecting the expression of immunoglobulin variable regions in the rabbit. Proc Natl Acad Sci USA. 83:1986;4883-4886.
10. Knight K.L., Becker R.S. Molecular basis of the allelic inheritance of rabbit immunoglobulin VH allotypes: implications for the generation of antibody diversity. Cell. 60:1990;963-970.
11. Becker R.S., Knight K.L. Somatic diversification of immunoglobulin heavy chain VDJ genses: evidence for somatic gene conversion in rabbits. Cell. 63:1990;987-997.
12. Allegucci M., Newman B.A., Young-Cooper G.O., Alexander C.B., Meier D., Kelus A.S., Mage R.G. Altered phenotypic expression of immunoglobulin heavy-chain variable-region (VH) genes in Alicia rabbits probably reflects a small deletion in the VH genes closest to the joining region. Proc Natl Acad Sci USA. 87:1990;5444-5448.
13. Pospisil R., Young-Cooper G.O., Mage R.G. Preferential expansion and survival of B lymphocytes based on VH framework 1 and framework 3 expression: 'positive' selection in appendix of normal and VH-mutant rabbits. Proc Natl Acad Sci USA. 92:1995;6961-6965.
14. Pospisil R., Mage R.G. B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix. Cell Immunol. 185:1998;93-100.
15. Pospisil R., Mage R.G. Rabbit appendix: a site of development and selection of the B cell repertoire. Curr Top Microbiol Immunol. 229:1998;59-70.
16. Sehgal D., Mage R.G., Schiaffella E. VH mutant rabbits lacking the VH1a2 gene develop a2+B cells in the appendix by gene conversion-like alteration of a rearranged VH4 gene. J Immunol. 160:1998;1246-1255.
17. Butcher E.C., Picker L.J. Lymphocyte homing and homeostasis. Science. 272:1996;60-66.
18. Hemmerich S., Butcher E.C., Rosen S.D. Sulfation-dependent recognition of HEV-ligands by L-selectin and MECA-79, an adhesion-blocking mAb. J Exp Med. 180:1994;2219-2226.
19. Rosen S.D. Endothelial ligands for L-selectin: from lymphocyte recirculation to allograft rejection. Am J Pathol. 155:1999;1013-1020.
20. Campbell J.J., Hedrick J., Zlotnik A., Siani M.A., Thompson D.A., Butcher E.C. Chemokines and the arrest of lymphocytes rolling under flow conditions. Science. 279:1998;381-384.
21. Stein J.V., Rot A., Luo Y., Narasimhaswamy M., Nakoano H., Gunn M.D., Matsuzawa A., Quackenbush E.J., Dorf M.E., von Andrian U.H. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, Exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J Exp Med. (191):2000;61-76.
22. Hwang S.T., Singer M.S., Giblin P.A., Yednock T.A., Bacon K.B., Simon S.I., Rosen S.D. GlyCAM-1, a physiological ligand for L-selectin, activates β2 integrins on naive peripheral lymphocytes. J Exp Med. 184:1996;1343-1348.
23. Cyster J.G. Chemkines and cell migration in secondary lymphoid organs. Science. 286:1999;2098-2102.
24. Reif K., Ekland E.H., Ohl L., Nakano H., Lipp M., Forester R., Cyster J.G. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature. 416:2002;94-99.
25. Masteller E.L., Larsen R.D., Carlson L.M., Pickel J.M., Nickoloff B., Lowe J., Thompson C.B., Lee K.P. Chicken B cells undergo discreate developmental changes in surface carbohydrate structure that appear to play a role in directing lymphocyte migration during embryogenesis. Development. 121:1995;1657-1667.
26. Masteller E.L., Lee K.P., Carlson L.M., Thompson C.B. Expression of sialyl Lewis (x) and Lewis (x) defines distinct stages of chicken B cell maturation. J Immunol. 155:1995;5550-5556.
27. Mitsuoka C., Sawada-Kasugai M., Ando-Furui K., Izawa M., Nakanishi H., Nakamura S., Ishida H., Kiso M., Kannagi R. Identification of a major carbohydrate capping group of the L-selectin ligand on high endothelial venules in human lymph nodes as 6-sulfo sialy Lewis X. J Biol Chem. 273:1998;11225- 11233.
28. McEver R.P., Moore K.L., Cummings R.D. Leukocyte trafficking mediated by selectin-carbohydrate interactions. J Biol Chem. 270:1995;11025-11028.
29. Tedder T.F., Steeber D.A., Chen A., Engel P. The selectins: vascular adhesion molecules. FASEB J. 9:1995;866-873.
30. Van Zante A., Rosen S.D. Sulphated endothelial ligands for L-selectin in lymphocyte homing and inflammation. Biochem Soc Trans. 31:2003;313-317.
31. Spertini O., Freedman A.S., Belvin M.P., Penta A.C., Griffin J.D., Teddrer T.F. Regulation of leukocyte adhesion molecule-1 (TQ1 Leu-8) expression and shedding by normal and malignant cells. Leukemia. 5:1991;300-308.
32. Varki A. Selectin ligands. Proc Natl Acad Sci USA. 91:1994;7390-7397.
33. Streeter P., Berg E., Rouse T., Bargatze R., Butcher E. A tissue-specific endothelial cell molecule involved in lymphocyte homing. Nature. 331:1988;41-43.
34. Steeber D.A., Tang M.L., Zhang X.Q., Muller W., Wagner N., Tedder T.F. Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. J Immunol. 161:1998;6638-6647.
35. Sawada M., Takada A., Ohwaki I., Takahashi N., Tateno H., Sakamoto J., Kannagi R. Specific expression of a complex sialyl Lewis X antigen on high endothelial venules of human lymph nodes: possible candidate for L-selectin ligand. Biochem Biophys Res Commun. 193:1993;337-347.
36. Akimoto H., McDonald T.O., Weyhrich J.T., Thomas R., Rothnie C.L., Allen M.D. Antibody to CD18 reduces neutrophil and T lymphocyte infiltration and vascular cell adhesion molecule-1 expression in cardiac rejection. Transplantation. 61:1996;1610-1617.
37. Berlin-Rufenach C., Otto F., Mathies M., Westermann J., Owen M.J., Hamann A., Hogg N. Lymphocyte migration in lymphocyte function-associated antigen (LFA)-1-deficient mice. J Exp Med. 189:1999;1467-1478.
38. Lo C.G., Lu T.T., Cyster J.G. Integrin-dependence of lymphocyte entry into the splenic white pulp. J Exp Med. 197:2003;353-361.
39. Winn R.K., Harlan J.M. CD18-independent neutrophil and mononuclear leukocyte emigration into the peritoneum of rabbits. J Clin Invest. 92:1993;1168-1173.
40. Hernandez-Caselles T., Matinez-Esparza M., Lazarovits A.I., Aparicio P. Specific regulation of VLA-4 and alpha 4 beta 7 integrin expression of human activated T lymphocytes. J Immunol. 156:1996;3668-3677.
41. Vassileva G., Soto H., Zlotnik A., Nakano H., Kakiuchi T., Hedrick J.A., Lira S.A. The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes. J Exp Med. 190:1999;1183-1188.
42. Gunn M.D., Kyuwa S., Tam C., Kakiuchi T., Matsuzawa A., Williams L.T., Nakano H. Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J Exp Med. 189:1999;451-460.
43. Okada T., Ngo V.N., Ekland E.H., Forster R., Lipp M., Littman D.R., Cyster J.G. Chemokine requirements for B cell entry to lymph nodes and Peyer's patches. J Exp Med. 196:2002;65-75.
44. Aragay A.M., Ruiz-Gomez A., Penela P., Sarnago S., Elorza A., Jimenez-Sainz M.C., Mayor J.F. G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions. FEBS Lett. 430:1998;37-40.
45. Signoret N., Rosenkilde M.M., Klasse P.J., Schwartz T.W., Malim M.H., Hoxie J.A., Marsh M. Differential regulation of CXCR4 and CCR5 endocytosis. J Cell Sci. 111:1998;2819-2830.
46. Chuang T.T., lacovelli L., Sallese M., De Blasi A. G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications. Trends Pharmacol Sci. 17:1996;416-421.
47. Förster R., Mattis A.E., Kremmer E., Wolf E., Brem G., Lipp M. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell. 87:1996;1037-1047.