Generation of heterogeneous rabbit anti-DNP antibodies by gene conversion and hypermutation of rearranged V(L) and V(H) genes during clonal expansion of B cells in splenic germinal centers

European Journal of Immunology

Volumn 30, Issue 12, 2000, Pages 3634-3644

  Sehgal, Devinder ^a   Schiaffella, Enrico ^b   Anderson, Arthur O ^b   Mage, Rose G ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

Gene conversion; Germinal center; Immunoglobulin light chain; Rabbit; Spleen

Indexed keywords

AMINO ACID; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL CLONE; GENE AMPLIFICATION; GENE CONVERSION; GENE MUTATION; GENE SEQUENCE; GERMINAL CENTER; INTESTINE LYMPHATIC TISSUE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RABBIT; UNINDEXED SEQUENCE;

AMINO ACID SEQUENCE; ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; COMPLEMENTARITY DETERMINING REGIONS; DINITROBENZENES; GENE CONVERSION; GENE REARRANGEMENT; GENES, IMMUNOGLOBULIN; GERMINAL CENTER; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; MUTATION; RABBITS; SPLEEN;

EID: 0034529754     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200012)30:12<3634::AID-IMMU3634>3.0.CO;2-7     Document Type: Article

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