메뉴 건너뛰기




Volumn 39, Issue 2, 2006, Pages 229-247

Molecular Biology of Oral Cavity Squamous Cell Carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CANCER VACCINE; CETUXIMAB; CHEMOKINE RECEPTOR ANTAGONIST; CYCLIN D1; DALTEPARIN; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; JANUS KINASE; MATRIX METALLOPROTEINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR INHIBITOR; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P53; PROTEIN TYROSINE KINASE INHIBITOR; SIBROTUZUMAB; STAT3 PROTEIN; SURAMIN; SURVIVIN; THROMBOCYTE GROWTH FACTOR ANTIBODY; UNCLASSIFIED DRUG; UNINDEXED DRUG; UVOMORULIN; VASCULOTROPIN; VASCULOTROPIN ANTIBODY; VASCULOTROPIN INHIBITOR;

EID: 33645851349     PISSN: 00306665     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.otc.2005.11.003     Document Type: Review
Times cited : (20)

References (72)
  • 3
    • 17844382964 scopus 로고    scopus 로고
    • Epidemiology of head and neck cancer: magnitude of the problem
    • Dobrossy L. Epidemiology of head and neck cancer: magnitude of the problem. Cancer Metastasis Rev 24 (2005) 9-17
    • (2005) Cancer Metastasis Rev , vol.24 , pp. 9-17
    • Dobrossy, L.1
  • 4
    • 2342517421 scopus 로고    scopus 로고
    • Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck
    • Cooper J.S., Pajak T.F., Forastiere A.A., et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med 350 (2004) 1937-1944
    • (2004) N Engl J Med , vol.350 , pp. 1937-1944
    • Cooper, J.S.1    Pajak, T.F.2    Forastiere, A.A.3
  • 7
    • 78651056338 scopus 로고
    • Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin
    • Slaughter D.P., Southwick H.W., and Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6 (1953) 963-968
    • (1953) Cancer , vol.6 , pp. 963-968
    • Slaughter, D.P.1    Southwick, H.W.2    Smejkal, W.3
  • 8
    • 0023261211 scopus 로고
    • Clonal analysis of human colorectal tumors
    • Fearon E.R., Hamilton S.R., and Vogelstein B. Clonal analysis of human colorectal tumors. Science 238 (1987) 193-197
    • (1987) Science , vol.238 , pp. 193-197
    • Fearon, E.R.1    Hamilton, S.R.2    Vogelstein, B.3
  • 9
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E.R., and Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 61 (1990) 759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 10
    • 9344247476 scopus 로고    scopus 로고
    • Genetic progression model for head and neck cancer: implications for field cancerization
    • Califano J., van der Riet P., Westra W., et al. Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 56 (1996) 2488-2492
    • (1996) Cancer Res , vol.56 , pp. 2488-2492
    • Califano, J.1    van der Riet, P.2    Westra, W.3
  • 11
    • 0029929885 scopus 로고    scopus 로고
    • Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment
    • Mao L., Lee J.S., Fan Y.H., et al. Frequent microsatellite alterations at chromosomes 9p21 and 3p14 in oral premalignant lesions and their value in cancer risk assessment. Nat Med 2 (1996) 682-685
    • (1996) Nat Med , vol.2 , pp. 682-685
    • Mao, L.1    Lee, J.S.2    Fan, Y.H.3
  • 12
    • 0027524636 scopus 로고
    • The incidence of p53 mutations increases with progression of head and neck cancer
    • Boyle J.O., Hakim J., Koch W., et al. The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res 53 (1993) 4477-4480
    • (1993) Cancer Res , vol.53 , pp. 4477-4480
    • Boyle, J.O.1    Hakim, J.2    Koch, W.3
  • 13
    • 0031022938 scopus 로고    scopus 로고
    • Field cancerisation and polyclonal p53 mutation in the upper aero-digestive tract
    • Waridel F., Estreicher A., Bron L., et al. Field cancerisation and polyclonal p53 mutation in the upper aero-digestive tract. Oncogene 14 (1997) 163-169
    • (1997) Oncogene , vol.14 , pp. 163-169
    • Waridel, F.1    Estreicher, A.2    Bron, L.3
  • 14
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn E.H. Switching and signaling at the telomere. Cell 106 (2001) 661-673
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 15
    • 0029769788 scopus 로고    scopus 로고
    • Telomerase activity in head and neck squamous cell carcinoma and adjacent tissues
    • Mao L., El-Naggar A.K., Fan Y.H., et al. Telomerase activity in head and neck squamous cell carcinoma and adjacent tissues. Cancer Res 56 (1996) 5600-5604
    • (1996) Cancer Res , vol.56 , pp. 5600-5604
    • Mao, L.1    El-Naggar, A.K.2    Fan, Y.H.3
  • 16
    • 0037105785 scopus 로고    scopus 로고
    • Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia
    • Kresty L.A., Mallery S.R., Knobloch T.J., et al. Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia. Cancer Res 62 (2002) 5295-5300
    • (2002) Cancer Res , vol.62 , pp. 5295-5300
    • Kresty, L.A.1    Mallery, S.R.2    Knobloch, T.J.3
  • 17
    • 0037446974 scopus 로고    scopus 로고
    • A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications
    • Braakhuis B.J., Tabor M.P., Kummer J.A., et al. A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res 63 (2003) 1727-1730
    • (2003) Cancer Res , vol.63 , pp. 1727-1730
    • Braakhuis, B.J.1    Tabor, M.P.2    Kummer, J.A.3
  • 18
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B., and Kinzler K.W. Cancer genes and the pathways they control. Nat Med 10 (2004) 789-799
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 19
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • Mendelsohn J., and Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 21 (2003) 2787-2799
    • (2003) J Clin Oncol , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 20
    • 0034658499 scopus 로고    scopus 로고
    • STAT signaling in head and neck cancer
    • Song J.I., and Grandis J.R. STAT signaling in head and neck cancer. Oncogene 19 (2000) 2489-2495
    • (2000) Oncogene , vol.19 , pp. 2489-2495
    • Song, J.I.1    Grandis, J.R.2
  • 21
    • 10844223748 scopus 로고    scopus 로고
    • Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis
    • Vitale-Cross L., Amornphimoltham P., Fisher G., et al. Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis. Cancer Res 64 (2004) 8804-8807
    • (2004) Cancer Res , vol.64 , pp. 8804-8807
    • Vitale-Cross, L.1    Amornphimoltham, P.2    Fisher, G.3
  • 22
    • 0015043748 scopus 로고
    • Mutation and cancer: statistical study of retinoblastoma
    • Knudson Jr. A.G. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 68 (1971) 820-823
    • (1971) Proc Natl Acad Sci U S A , vol.68 , pp. 820-823
    • Knudson Jr., A.G.1
  • 23
    • 0037157786 scopus 로고    scopus 로고
    • Cancer genetics
    • Knudson A.G. Cancer genetics. Am J Med Genet 111 (2002) 96-102
    • (2002) Am J Med Genet , vol.111 , pp. 96-102
    • Knudson, A.G.1
  • 24
  • 25
    • 11844293427 scopus 로고    scopus 로고
    • p53 and prognosis: new insights and further complexity
    • Vousden K.H., and Prives C. p53 and prognosis: new insights and further complexity. Cell 120 (2005) 7-10
    • (2005) Cell , vol.120 , pp. 7-10
    • Vousden, K.H.1    Prives, C.2
  • 26
    • 0842346437 scopus 로고    scopus 로고
    • Principles of tumor suppression
    • Sherr C.J. Principles of tumor suppression. Cell 116 (2004) 235-246
    • (2004) Cell , vol.116 , pp. 235-246
    • Sherr, C.J.1
  • 27
    • 0036836259 scopus 로고    scopus 로고
    • Inactivation of the PTEN gene by mutation, exonic deletion, and loss of transcript in human oral squamous cell carcinomas
    • Shin K.H., Kim J.M., Rho K.S., et al. Inactivation of the PTEN gene by mutation, exonic deletion, and loss of transcript in human oral squamous cell carcinomas. Int J Oncol 21 (2002) 997-1001
    • (2002) Int J Oncol , vol.21 , pp. 997-1001
    • Shin, K.H.1    Kim, J.M.2    Rho, K.S.3
  • 28
    • 0037268338 scopus 로고    scopus 로고
    • The Fanconi anaemia/BRCA pathway
    • D'Andrea A.D., and Grompe M. The Fanconi anaemia/BRCA pathway. Nat Rev Cancer 3 (2003) 23-34
    • (2003) Nat Rev Cancer , vol.3 , pp. 23-34
    • D'Andrea, A.D.1    Grompe, M.2
  • 29
    • 24944497114 scopus 로고    scopus 로고
    • The Fanconi anemia group. A protein modulates homologous repair of DNA double-strand breaks in mammalian cells
    • Yang Y.G., Herceg Z., Nakanishi K., et al. The Fanconi anemia group. A protein modulates homologous repair of DNA double-strand breaks in mammalian cells. Carcinogenesis (2005)
    • (2005) Carcinogenesis
    • Yang, Y.G.1    Herceg, Z.2    Nakanishi, K.3
  • 30
    • 1342301467 scopus 로고    scopus 로고
    • Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival
    • Marsit C.J., Liu M., Nelson H.H., et al. Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival. Oncogene 23 (2004) 1000-1004
    • (2004) Oncogene , vol.23 , pp. 1000-1004
    • Marsit, C.J.1    Liu, M.2    Nelson, H.H.3
  • 31
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 32
    • 0032478998 scopus 로고    scopus 로고
    • Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival
    • Rubin Grandis J., Melhem M.F., et al. Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 90 (1998) 824-832
    • (1998) J Natl Cancer Inst , vol.90 , pp. 824-832
    • Rubin Grandis, J.1    Melhem, M.F.2
  • 33
    • 0033372557 scopus 로고    scopus 로고
    • Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members
    • Xia W., Lau Y.K., Zhang H.Z., et al. Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clin Cancer Res 5 (1999) 4164-4174
    • (1999) Clin Cancer Res , vol.5 , pp. 4164-4174
    • Xia, W.1    Lau, Y.K.2    Zhang, H.Z.3
  • 34
    • 2342591455 scopus 로고    scopus 로고
    • The discovery of receptor tyrosine kinases: targets for cancer therapy
    • Gschwind A., Fischer O.M., and Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 4 (2004) 361-370
    • (2004) Nat Rev Cancer , vol.4 , pp. 361-370
    • Gschwind, A.1    Fischer, O.M.2    Ullrich, A.3
  • 35
    • 0036340532 scopus 로고    scopus 로고
    • Targeted molecular therapy for oral cancer with epidermal growth factor receptor blockade: a preliminary report
    • Myers J.N., Holsinger F.C., Bekele B.N., et al. Targeted molecular therapy for oral cancer with epidermal growth factor receptor blockade: a preliminary report. Arch Otolaryngol Head Neck Surg 128 (2002) 875-879
    • (2002) Arch Otolaryngol Head Neck Surg , vol.128 , pp. 875-879
    • Myers, J.N.1    Holsinger, F.C.2    Bekele, B.N.3
  • 36
    • 7444227578 scopus 로고    scopus 로고
    • Tumor cell and endothelial cell therapy of oral cancer by dual tyrosine kinase receptor blockade
    • Yigitbasi O.G., Younes M.N., Doan D., et al. Tumor cell and endothelial cell therapy of oral cancer by dual tyrosine kinase receptor blockade. Cancer Res 64 (2004) 7977-7984
    • (2004) Cancer Res , vol.64 , pp. 7977-7984
    • Yigitbasi, O.G.1    Younes, M.N.2    Doan, D.3
  • 37
    • 33645858725 scopus 로고    scopus 로고
    • Bonner J, Giralt J, Harari P, et al. Cetuximab prolongs survival in patients with locoregionally advanced squamous cell carcinoma of head and neck: a phase III study of high dose radiation therapy with or without cetuximab. In: Proceedings of the annual meeting of the American Society of Clinical Oncology. New Orleans, LA; June 5-8, 2004. p. 5507.
  • 38
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer-new molecular targets come of age
    • Yu H., and Jove R. The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 4 (2004) 97-105
    • (2004) Nat Rev Cancer , vol.4 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 39
    • 0037096876 scopus 로고    scopus 로고
    • Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma
    • Masuda M., Suzui M., Yasumatu R., et al. Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell carcinoma. Cancer Res 62 (2002) 3351-3355
    • (2002) Cancer Res , vol.62 , pp. 3351-3355
    • Masuda, M.1    Suzui, M.2    Yasumatu, R.3
  • 40
    • 0013689209 scopus 로고    scopus 로고
    • Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
    • Grandis J.R., Drenning S.D., Chakraborty A., et al. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro. J Clin Invest 102 (1998) 1385-1392
    • (1998) J Clin Invest , vol.102 , pp. 1385-1392
    • Grandis, J.R.1    Drenning, S.D.2    Chakraborty, A.3
  • 42
    • 12944272024 scopus 로고    scopus 로고
    • Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
    • Grandis J.R., Drenning S.D., Zeng Q., et al. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. Proc Natl Acad Sci U S A 97 (2000) 4227-4232
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4227-4232
    • Grandis, J.R.1    Drenning, S.D.2    Zeng, Q.3
  • 43
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell 81 (1995) 323-330
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 44
    • 0036559896 scopus 로고    scopus 로고
    • Papillomaviruses and cancer: from basic studies to clinical application
    • zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2 (2002) 342-350
    • (2002) Nat Rev Cancer , vol.2 , pp. 342-350
    • zur Hausen, H.1
  • 45
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: critical control points
    • Danial N.N., and Korsmeyer S.J. Cell death: critical control points. Cell 116 (2004) 205-219
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 46
    • 5044232018 scopus 로고    scopus 로고
    • Connecting proliferation and apoptosis in development and disease
    • Hipfner D.R., and Cohen S.M. Connecting proliferation and apoptosis in development and disease. Nat Rev Mol Cell Biol 5 (2004) 805-815
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 805-815
    • Hipfner, D.R.1    Cohen, S.M.2
  • 47
    • 0032479321 scopus 로고    scopus 로고
    • E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells
    • Kantak S.S., and Kramer R.H. E-cadherin regulates anchorage-independent growth and survival in oral squamous cell carcinoma cells. J Biol Chem 273 (1998) 16953-16961
    • (1998) J Biol Chem , vol.273 , pp. 16953-16961
    • Kantak, S.S.1    Kramer, R.H.2
  • 48
    • 0026721505 scopus 로고
    • Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes
    • Korsmeyer S.J. Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Annu Rev Immunol 10 (1992) 785-807
    • (1992) Annu Rev Immunol , vol.10 , pp. 785-807
    • Korsmeyer, S.J.1
  • 49
    • 0035252742 scopus 로고    scopus 로고
    • Abnormalities of the ARF-p53 pathway in oral squamous cell carcinoma
    • Bradley G., Irish J., MacMillan C., et al. Abnormalities of the ARF-p53 pathway in oral squamous cell carcinoma. Oncogene 20 (2001) 654-658
    • (2001) Oncogene , vol.20 , pp. 654-658
    • Bradley, G.1    Irish, J.2    MacMillan, C.3
  • 50
    • 3042531148 scopus 로고    scopus 로고
    • Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01
    • Amornphimoltham P., Sriuranpong V., Patel V., et al. Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin Cancer Res 10 (2004) 4029-4037
    • (2004) Clin Cancer Res , vol.10 , pp. 4029-4037
    • Amornphimoltham, P.1    Sriuranpong, V.2    Patel, V.3
  • 51
    • 0034051179 scopus 로고    scopus 로고
    • Prognostic significance of apoptosis and associated factors in oral squamous cell carcinoma
    • Stoll C., Baretton G., Ahrens C., et al. Prognostic significance of apoptosis and associated factors in oral squamous cell carcinoma. Virchows Arch 436 (2000) 102-108
    • (2000) Virchows Arch , vol.436 , pp. 102-108
    • Stoll, C.1    Baretton, G.2    Ahrens, C.3
  • 52
    • 0031264540 scopus 로고    scopus 로고
    • Mortality and immortality at the cellular level. A review
    • Hayflick L. Mortality and immortality at the cellular level. A review. Biochemistry (Mosc) 62 (1997) 1180-1190
    • (1997) Biochemistry (Mosc) , vol.62 , pp. 1180-1190
    • Hayflick, L.1
  • 53
    • 0034798128 scopus 로고    scopus 로고
    • Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ
    • Kim H.R., Christensen R., Park N.H., et al. Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ. Clin Cancer Res 7 (2001) 3079-3086
    • (2001) Clin Cancer Res , vol.7 , pp. 3079-3086
    • Kim, H.R.1    Christensen, R.2    Park, N.H.3
  • 54
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 285 (1971) 1182-1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 55
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin D.J., and Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23 (2005) 1011-1027
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 56
    • 0034111116 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma
    • Smith B.D., Smith G.L., Carter D., et al. Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma. J Clin Oncol 18 (2000) 2046-2052
    • (2000) J Clin Oncol , vol.18 , pp. 2046-2052
    • Smith, B.D.1    Smith, G.L.2    Carter, D.3
  • 57
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    • Winkler F., Kozin S.V., Tong R.T., et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 6 (2004) 553-563
    • (2004) Cancer Cell , vol.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3
  • 58
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350 (2004) 2335-2342
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 59
    • 0035936807 scopus 로고    scopus 로고
    • Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin
    • Vasioukhin V., Bauer C., Degenstein L., et al. Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell 104 (2001) 605-617
    • (2001) Cell , vol.104 , pp. 605-617
    • Vasioukhin, V.1    Bauer, C.2    Degenstein, L.3
  • 60
    • 16444368642 scopus 로고    scopus 로고
    • E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs
    • Margulis A., Zhang W., Alt-Holland A., et al. E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs. Cancer Res 65 (2005) 1783-1791
    • (2005) Cancer Res , vol.65 , pp. 1783-1791
    • Margulis, A.1    Zhang, W.2    Alt-Holland, A.3
  • 61
    • 1642535493 scopus 로고    scopus 로고
    • Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue
    • Lim S.C., Zhang S., Ishii G., et al. Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue. Clin Cancer Res 10 (2004) 166-172
    • (2004) Clin Cancer Res , vol.10 , pp. 166-172
    • Lim, S.C.1    Zhang, S.2    Ishii, G.3
  • 62
    • 5044238876 scopus 로고    scopus 로고
    • Integrin signalling during tumour progression
    • Guo W., and Giancotti F.G. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 5 (2004) 816-826
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 816-826
    • Guo, W.1    Giancotti, F.G.2
  • 63
    • 0033079605 scopus 로고    scopus 로고
    • The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene
    • Christofori G., and Semb H. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci 24 (1999) 73-76
    • (1999) Trends Biochem Sci , vol.24 , pp. 73-76
    • Christofori, G.1    Semb, H.2
  • 64
    • 0033637209 scopus 로고    scopus 로고
    • Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression
    • Kupferman M.E., Fini M.E., Muller W.J., et al. Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression. Am J Pathol 157 (2000) 1777-1783
    • (2000) Am J Pathol , vol.157 , pp. 1777-1783
    • Kupferman, M.E.1    Fini, M.E.2    Muller, W.J.3
  • 65
    • 0842311599 scopus 로고    scopus 로고
    • Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis
    • Katayama A., Bandoh N., Kishibe K., et al. Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis. Clin Cancer Res 10 (2004) 634-640
    • (2004) Clin Cancer Res , vol.10 , pp. 634-640
    • Katayama, A.1    Bandoh, N.2    Kishibe, K.3
  • 66
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: twist in development and metastasis
    • Kang Y., and Massague J. Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118 (2004) 277-279
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1    Massague, J.2
  • 67
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J., Mani S.A., Donaher J.L., et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117 (2004) 927-939
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3
  • 68
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2 (2002) 442-454
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 69
    • 20044363080 scopus 로고    scopus 로고
    • Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity
    • O'Donnell R.K., Kupferman M., Wei S.J., et al. Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity. Oncogene 24 (2005) 1244-1251
    • (2005) Oncogene , vol.24 , pp. 1244-1251
    • O'Donnell, R.K.1    Kupferman, M.2    Wei, S.J.3
  • 70
    • 13444269762 scopus 로고    scopus 로고
    • An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas
    • Roepman P., Wessels L.F., Kettelarij N., et al. An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nat Genet 37 (2005) 182-186
    • (2005) Nat Genet , vol.37 , pp. 182-186
    • Roepman, P.1    Wessels, L.F.2    Kettelarij, N.3
  • 71
    • 0037137519 scopus 로고    scopus 로고
    • A gene-expression signature as a predictor of survival in breast cancer
    • van de Vijver M.J., He Y.D., van't Veer L.J., et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 347 (2002) 1999-2009
    • (2002) N Engl J Med , vol.347 , pp. 1999-2009
    • van de Vijver, M.J.1    He, Y.D.2    van't Veer, L.J.3
  • 72
    • 20444412646 scopus 로고    scopus 로고
    • Therapeutic targeting of the tumor microenvironment
    • Joyce J.A. Therapeutic targeting of the tumor microenvironment. Cancer Cell 7 (2005) 513-520
    • (2005) Cancer Cell , vol.7 , pp. 513-520
    • Joyce, J.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.