Small RNA-directed DNA methylation and tumorigenesis

Progress in Biochemistry and Biophysics

Volumn 33, Issue 1, 2006, Pages 10-16

  Guo, Wei Rui ^a,b   Yin, James Q ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

DNA methylation; Gene silencing; siRNA

Indexed keywords

EID: 33645767669     PISSN: 10003282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (38)

1. Yin J Q, Wang Y. siRNA-mediated gene regulation system: now and the future. Int J Mol Med, 2002, 10 (4): 355-365
2. Bachman K E, Park B H, Rhee I, et al. Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene. Cancer Cell, 2003, 3 (1): 89-95
3. Matzke M, Aufsatz W, Kanno T, et al. Genetic analysis of RNA-mediated transcriptional gene silencing. Biochim Biophys Acta, 2004, 1677 (1-3): 129-141
4. Yin J Q, Jiang L. MiRNA-directed gene intertalk. Chin Acad Forum, 2004, 11 (20): 1-4
5. Ambros V, Lee R C, Lavanway P, et al. miRNAs and other tiny endogenous RNAs in C. elegans. Curr Biol, 2003, 13 (10): 807-818
6. Allen E, Xie Z, Gustafson A M, et al. microRNA-directed phasing during trans-acting siRNA biogenesis in plants. Cell, 2005, 121 (2): 207-21
7. Hammond S, Boettcher S, Caudy A, et al. Argonaute 2, a link between genetic and biochemical analyses of RNAi. Science, 2001, 293 (5532): 1146-1150
8. Ma J B, Yuan Y R, Meister G, et al. Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature, 2005, 434 (7033): 666-670
9. Noma K, Sugiyama T, Cam H, et al. RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing. Nat Genet, 2004, 36 (11): 1174-1180
10. Wassenegger M, Heimes S, Riedel L, et al. RNA-directed de novo methylation of genomic sequences in plants. Cell, 1994, 76 (3): 567-576
11. Mette M F, Aufsatz W, van der Winden J, et al. Transcriptional silencing and promoter methylation triggered by double-stranded RNA. EMBO J, 2000, 19 (19): 5194-5201
12. Aufsatz W, Mette M F, van der Winden J, et al. RNA-directed DNA methylation in Arabidopsis. Proc Natl Acad Sci USA, 2002, 99 (Suppl 4): 16499-16506
13. Wassenegger M. RNA-directed DNA methylation. Plant Mol Biol, 2000, 43 (2-3): 203-220
14. Schauer S E, Jacobsen S E, Meinke D W, et al. DICER-LIKE1: blind men and elephants in Arabidopsis development. Trends Plant Sci, 2002, 7 (11): 487-491
15. Papp I, Mette M F, Aufsatz W, et al. Evidence for nuclear processing of plant microRNA and short interfering RNA precursors. Plant Physiol, 2003, 132 (3): 1382-1390
16. Zilberman D, Cao X, Jacobsen S E. ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science, 2003, 299 (5607): 716-719
17. Vaucheret H, Vazquez F, Crete P, et al. The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway a crucial for plant development. Genes Dev, 2004, 18 (10): 1187-1197
18. Lippman Z, Gendrel A V, Black M, et al. Role of transposable elements in heterochromatin and epigenetic control. Nature, 2004, 430 (6998): 471-476
19. Kanno T, Mette M F, Kreil D P, et al. Involvement of putative SNF2 chromatin remodeling protein DRD1 in RNA-directed DNA methylation. Curr Biol, 2004, 14 (9): 810-805
20. Dennis K, Fan T, Geiman T, et al. A member of the SNF2 family, is required for genome-wide methylation. Genes Dev, 2001, 15 (22): 2940-2944
21. Cao X, Jacobsen S E. Role of the Arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing. Curr Biol, 2002, 12 (13): 1138-1144
22. Howell C Y, Bestor T H, Ding F, et al. Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene. Cell, 2001, 104 (6): 829-838
23. Kankel M W, Ramsey D E, Stokes T L, et al. Arabidopsis MET1 cytosine methyltransferase mutants. Genetics, 2003, 163 (3): 1109-1122
24. Lindroth A M, Cao X, Jackson J P, et al. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. Science, 2001, 292 (5524): 2077-2080
25. Aufsatz W, Mette M F, van der Winden J, et al. HDA6, a putative histone deacetylase needed to enhance DNA methylation induced by double-stranded RNA. EMBO J, 2002, 21 (24): 6832-6841
26. Bestor T H. The DNA methyltransferases of mammals. Hum Mol Genet, 2000, 9 (16): 2395-2402
27. Cao X, Aufsatz W, Zilberman D, et al. Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation. Curr Biol, 2003, 13 (24): 2212-2217
28. Aufsatz W, Mette M F, Matzke A J, et al. The role of MET1 in RNA-directed de novo and maintenance methylation of CG dinucleotides. Plant Mol Biol, 2004, 54 (6): 793-804
29. Matzke M A, Birchler J A. RNAi-mediated pathways in the nucleus. Nat Rev Genet, 2005, 6 (1): 24-35
30. Szyf M. DNA methylation and demethylation as targets for anticancer therapy. Biochemistry (Mosc), 2005, 70 (5): 533-549
31. Knudson A G. Two genetic hits (more or less) to cancer. Nat Rev Cancer, 2001, 1 (2): 157-162
32. Kawasaki H, Taira K. Induction of DNA methylation and gene silencing by short interfering RNAs in human cells. Nature, 2004, 431 (7005): 211-217
33. Morris K V, Chan S W, Jacobsen S E, et al. Small interfering RNA-induced transcriptional gene silencing in human cells. Science, 2004, 305 (5688): 1289-1292
34. Kawasaki H, Taira K, Morris K V. siRNA induced transcriptional gene silencing in mammalian cells. Cell Cycle, 2005, 4 (3): 442-448
35. Egger G, Liang G, Aparicio A, et al. Epigenetics in human disease and prospects for epigenetic therapy. Nature, 2004, 429 (6990): 457-463
36. Liu T G, Yin J Q, Shang B Y, et al. Silencing of hdm2 oncogene by siRNA inhibits p53-dependent human breast cancer. Cancer Gene Ther, 2004, 11 (11): 748-756
37. Tan F L, Yin J Q. Application of RNAi to cancer research and therapy. Front Biosci, 2005, 10: 1946-1960
38. Swanton C, Nicke B, Downward J. RNA interference, DNA methylation, and gene silencing: a bright future for cancer therapy?. Lancet Oncol, 2004, 5 (11): 653-654