WTC deafness Kyoto (dfk): A rat model for extensive investigations of Kcnq1 functions

Physiological Genomics

Volumn 24, Issue 3, 2006, Pages 198-206

  Gohma, Hiroshi ^a   Kuramoto, Takashi ^a   Kuwamura, Mitsuru ^b   Okajima, Ryoko ^b   Tanimoto, Noriaki ^c   Yamasaki, Ken Ichi ^a   Nakanishi, Satoshi ^a   Kitada, Kazuhiro ^a,e   Makiyama, Takeru ^a   Akao, Masaharu ^a   Kita, Toru ^a   Sasa, Masashi ^d   Serikawa, Tadao ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Osaka Prefecture University   (Japan)

^c MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^d Nagisa Hospital   (Japan)

^e HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Achlorhydria; Deafness; Hypertension; Long QT syndrome; Voltage dependent potassium channel

Indexed keywords

POTASSIUM CHANNEL KCNQ1;

ACHLORHYDRIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BALANCE DISORDER; BLOOD PRESSURE MONITORING; BLOOD PRESSURE REGULATION; BODY EQUILIBRIUM; CONTROLLED STUDY; ELECTROCARDIOGRAM; ENDOLYMPH; GENE DELETION; GENE FUNCTION; GENE IDENTIFICATION; GENE MUTATION; HEARING IMPAIRMENT; HYPERTENSION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QT PROLONGATION; RAT; RAT STRAIN; STOMACH MUCOSA; WEIGHT GAIN;

ANIMALIA;

EID: 33645756344     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00221.2005     Document Type: Article

References (38)

1. + currents in isolated adult rat ventricular myocytes. J Gen Physiol 97: 973-1011, 1991.
2. Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, and Romey G. K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature 384: 78-80, 1996.
3. + currents in rat atrial myocytes. J Gen Physiol 100: 1041-1067, 1992.
4. Carlsson E, Larsson H, Mattsson H, Ryberg B, and Sundell G. Pharmacology and toxicology of omeprazole - with special reference to the effects on the gastric mucosa. Scand J Gastroenterol Suppl 118: 31-38, 1986.
5. Casimiro MC, Knollmann BC, Ebert SN, Vary JC Jr, Greene AE, Franz MR, Grinberg A, Huang SP, and Pfeifer K. Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange-Nielsen Syndrome. Proc Natl Acad Sci USA 98: 2526-2531, 2001.
6. Dedek K and Waldegger S. Colocalization of KCNQ1/KCNE channel subunits in the mouse gastrointestinal tract. Pflügers Arch 442: 896-902, 2001.
7. Demolombe S, Franco D, de Boer P, Kuperschmidt S, Roden D, Pereon Y, Jarry A, Moorman AF, and Escande D. Differential expression of KvLQT1 and its regulator IsK in mouse epithelia. Am J Physiol Cell Physiol 280: C359-C372, 2001.
8. Elso CM, Lu X, Culiat CT, Rutledge JC, Cacheiro NL, Generoso WM, and Stubbs LJ. Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice. Hum Mol Genet 13: 2813-2821, 2004.
9. + channel KCNQ1 is essential for gastric acid secretion. Gastroenterology 120: 1363-1371, 2001.
10. + channel, KCNQ1: expression, function, and subunit composition in murine trachea. J Biol Chem 276: 42268-42275, 2001.
11. Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, and Warth R. Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells. J Physiol 561: 547-557, 2004.
12. Jervell A and Lange-Nielsen F. Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death. Am Heart J 54: 59-68, 1957.
13. + channel KVLQT1. J Membr Biol 179: 155-164, 2001.
14. Kuramoto T, Kitada K, Inui T, Sasaki Y, Ito K, Hase T, Kawagachi S, Ogawa Y, Nakao K, Barsh GS, Nagao M, Ushijima T, and Serikawa T. Attractin/mahogany/ zitter plays a critical role in myelination of the central nervous system. Proc Natl Acad Sci USA 98: 559-564, 2001.
15. Kuramoto T, Yamasaki K, Kondo A, Nakajima K, Yamada M, and Serikawa T. Production of WTC.ZI-zi rat congenic strain and its pathological and genetic analyses. Exp Anim 47: 75-81, 1998.
16. Lee MP, Ravenel JD, Hu RJ, Lustig LR, Tomaselli G, Berger RD, Brandenburg SA, Litzi TJ, Bunton TE, Limb C, Francis H, Gorelikow M, Gu H, Washington K, Argani P, Goldenring JR, Coffey RJ, and Feinberg AP. Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J Clin Invest 106: 1447-1455, 2000.
17. - secretion in human airway epithelia. Am J Respir Cell Mol Biol 23: 283-289, 2000.
18. Mashimo T, Voigt B, Kuramoto T, and Serikawa T. Rat Phenome Project: the untapped potential of existing rat strains. J Appl Physiol 98: 371-379, 2005.
19. Mitchell GF, Jeron A, and Koren G. Measurement of heart rate and Q-T interval in the conscious mouse. Am J Physiol Heart Circ Physiol 274: H747-H751, 1998.
20. + channel diversity in the mammalian myocardium. J Physiol 525: 285-298, 2000.
21. Nerbonne JM and Kass RS. Physiology and molecular biology of ion channels contributing to ventricular repolarization. In: Cardiac Repolarization. Bridging Basic and Clinical Science, edited by Gussal IB and Antzelevitch C. Totowa, NJ: Humana, 2003, p. 25-62.
22. Neyroud N, Tesson F, Denjoy I, Leibovici M, Donger C, Barhanin J, Faure S, Gary F, Coumel P, Petit C, Schwartz K, and Guicheney P. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome. Nat Genet 15: 186-189, 1997.
23. - conductances in apical membrane vesicles from stimulated rabbit oxyntic cells. Am J Physiol Gastrointest Liver Physiol 259: G850-G858, 1990.
24. Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, and Keating MT. Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384: 80-83, 1996.
25. Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R, and Jentsch TJ. A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403: 196-199, 2000.
26. Silver LM. Mouse Genetics. New York: Oxford Univ. Press, 1995.
27. Taylor BA, Navin A, and Phillips SJ. PCR-amplification of simple sequence repeat variants from pooled DNA samples for rapidly mapping new mutations of the mouse. Genomics 21: 626-632, 1994.
28. Tosaka T, Casimiro MC, Rong Q, Tella S, Oh M, Katchman AN, Pezzullo JC, Pfeifer K, and Ebert SN. Nicotine induces a long QT phenotype in Kcnq1-deficient mouse hearts. J Pharmacol Exp Ther 306: 980-987, 2003.
29. Ullrich S, Su J, Ranta F, Wittekindt OH, Ris F, Rosler M, Gerlach U, Heitzmann D, Warth R, and Lang F. Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cells. Pflügers Arch 451: 428-436, 2005.
30. + fluxes in mouse proximal tubule. J Am Soc Nephrol 12: 2003-2011, 2001.
31. Vetter DE, Mann JR, Wangemann P, Liu J, McLaughlin KJ, Lesage F, Marcus DC, Lazdunski M, Heinemann SF, and Barhanin J. Inner ear defects induced by null mutation of the isk gene. Neuron 17: 1251-1264, 1996.
32. Walsh KB and Kass RS. Regulation of a heart potassium channel by protein kinase A and C. Science 242: 67-69, 1988.
33. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, Van-Raay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, and Keating MT. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 12: 17-23, 1996.
34. Ward OC. A new familial cardiac syndrome in children. J Ir Med Assoc 54: 103-106, 1964.
35. + currents via a pertussis toxin-sensitive mechanism. Circ Res 81: 211-218, 1997.
36. + current in rat ventricle. Am J Physiol Heart Circ Physiol 276: H1599-H1607, 1999.
37. +-ATPase membrane. Am J Physiol Cell Physiol 246: C537-C545, 1984.
38. Yang WP, Levesque PC, Little WA, Conder ML, Shalaby FY, and Blanar MA. KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc Natl Acad Sci USA 94: 4017-4021, 1997.