Cloning and function of the rat colonic epithelial K+ channel KvLQT1

Journal of Membrane Biology

Volumn 179, Issue 2, 2001, Pages 155-164

  Kunzelmann, K ^c   Hubner M ^a   Schreiber, R ^a   Levy Holzman, R ^b   Garty, H ^b   Bleich, M ^a   Warth, R ^a   Slavik, M ^a   Von Hahn, T ^a   Greger, R ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Cloning; Electrolyte secretion; Epithelium; Expression; Ion transport; K+ channel; Rat colon; rKvLQT1; rKCNQ1; Ussing chamber; Xenopus oocytes

Indexed keywords

TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; COLON MUCOSA; DNA LIBRARY; ELECTROLYTE TRANSPORT; HEART MUSCLE POTENTIAL; INTESTINE CRYPT; ION TRANSPORT; MOLECULAR CLONING; NONHUMAN; POTASSIUM TRANSPORT; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; XENOPUS;

1-METHYL-3-ISOBUTYLXANTHINE; AMINO ACID SEQUENCE; ANIMALS; BARIUM; CARBACHOL; CARDIOTONIC AGENTS; CLONING, MOLECULAR; COLON; CYCLIC AMP; DINOPROSTONE; FORSKOLIN; HUMANS; INTESTINAL MUCOSA; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; MALE; MOLECULAR SEQUENCE DATA; OOCYTES; PATCH-CLAMP TECHNIQUES; PHOSPHODIESTERASE INHIBITORS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ALIGNMENT; TETRAETHYLAMMONIUM; XENOPUS LAEVIS;

ANIMALIA;

EID: 0035863162     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002320010045     Document Type: Article

References (33)

1. Stilbenes and fenamates rescue the loss of I(KS) channel function induced by an LQT5 mutation and other IsK mutants
2. + channel blocker 293B
3. The role of the IsK protein in the specific pharmacological properties of the IKs channel complex
4. A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family
5. + channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias
6. + channels
7. Cyclic AMP-dependent regulation of K+ transport in the rat distal colon
8. The ion conductances of colonic crypts from dexamethasone-treated rats
9. Ion transport mechanisms n thick ascending limb of Henle's loop of mammalian nephron
10. Regulation of ion transport in colonic crypts
11. Mechanism of NaCl secretion in rectal gland tubules of spiny dogfish (Squalus acanthias). II. Effects of inhibitors
12. Mechanism of NaCl secretion in rectal gland tubules of spiny dogfish (Squalus acanthias). III. Effects of stimulation of secretion by cyclic AMP
13. Properties and regulation of the minK potassium channel protein
14. KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness
15. + conductance
16. Heteromultimeric CLC chloride channels with novel properties
17. vLQT1 potassium channel but not IsK is the molecular target for trans-6-cyano-4-(Nethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane
18. - secretion in murine nasal and colonic epithelia
19. Cholinergic ion secretion in human colon requires co-activation by cAMP
20. + conductance
21. - secretion in human airways
22. A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome
23. Abnormal epithelial transport in cystic fibrosis jejunum
24. + channels causes epilepsy
25. A constitutional open potassium channel formed by KCNQ1 and KCNE3
26. The IKs channel: Coassembly of IsK (minK) and KvLQT1 proteins
27. vLQT1 channels in strial marginal cells
28. Specific blockade of slowly activating IsK channels by chromanols-impact on the role of IsK channels in epithelia
29. Ion transport abnormalities in rectal suction biopsies from children with cystic fibrosis
30. Molecular and functional characterization of s-KCNQ1 potassium channel from rectal gland of Aqualus acanthias
31. + channels and colonic function
32. + conductance of rat colonic crypt base cells
33. vLQT1-related potassium channels responsible for an inherited idiopathic epilepsy