-
1
-
-
0028702018
-
Drug sensitivity ("suicide") genes for selective cancer chemotherapy
-
Moolten FL. Drug sensitivity ("suicide") genes for selective cancer chemotherapy. Cancer Gene Ther 1994;1:279-87.
-
(1994)
Cancer Gene Ther
, vol.1
, pp. 279-287
-
-
Moolten, F.L.1
-
2
-
-
0022485359
-
Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy
-
Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986;46:5276-81.
-
(1986)
Cancer Res
, vol.46
, pp. 5276-5281
-
-
Moolten, F.L.1
-
3
-
-
0036633912
-
Current progress in suicide gene therapy for cancer
-
Yazama K, Fisher WE, Brunicardi FC. Current progress in suicide gene therapy for cancer. World J Surg 2002;26:783-9.
-
(2002)
World J Surg
, vol.26
, pp. 783-789
-
-
Yazama, K.1
Fisher, W.E.2
Brunicardi, F.C.3
-
4
-
-
0026772206
-
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
-
Culver KW, Ram Z, Wallbridge S, Ishii H, Oldfield EH, Blaese RM. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992;256:1550-2.
-
(1992)
Science
, vol.256
, pp. 1550-1552
-
-
Culver, K.W.1
Ram, Z.2
Wallbridge, S.3
Ishii, H.4
Oldfield, E.H.5
Blaese, R.M.6
-
5
-
-
0032169967
-
Superior cytotoxicity with ganciclovir compared with acyclovir and 1-β-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: A novel paradigm for cell killing
-
Rubsam LZ, Davidson BL, Shewach DS. Superior cytotoxicity with ganciclovir compared with acyclovir and 1-β-D-arabinofuranosylthymine in herpes simplex virus-thymidine kinase-expressing cells: a novel paradigm for cell killing. Cancer Res 1998;58:3873-82.
-
(1998)
Cancer Res
, vol.58
, pp. 3873-3882
-
-
Rubsam, L.Z.1
Davidson, B.L.2
Shewach, D.S.3
-
6
-
-
0021055765
-
Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine, a new anti-herpes compound, in herpes simplex virus-infected cells
-
Cheng Y, Grill SP, Butschman GE, Nakayama K, Bastow KF. Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine, a new anti-herpes compound, in herpes simplex virus-infected cells. J Biol Chem 1983;258:12460-4.
-
(1983)
J Biol Chem
, vol.258
, pp. 12460-12464
-
-
Cheng, Y.1
Grill, S.P.2
Butschman, G.E.3
Nakayama, K.4
Bastow, K.F.5
-
7
-
-
0021739206
-
Phosphorylation of the antiviral percursor 9-(1,3-dihydroxy-2- propoxymethyl)guanine monophosphate by guanylate kinase isozymes
-
Boehme RE. Phosphorylation of the antiviral percursor 9-(1,3-dihydroxy-2-propoxymethyl)guanine monophosphate by guanylate kinase isozymes. J Biol Chem 1984;259:12346-9.
-
(1984)
J Biol Chem
, vol.259
, pp. 12346-12349
-
-
Boehme, R.E.1
-
8
-
-
0027480081
-
Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)- 2′-deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)-guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2
-
Balzarini J, Bohman C, De Clercq E. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2′-deoxyuridine, 9-(1,3-dihydroxy-2- propoxymethyl)-guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2. J Biol Chem 1993;268:6332-7.
-
(1993)
J Biol Chem
, vol.268
, pp. 6332-6337
-
-
Balzarini, J.1
Bohman, C.2
De Clercq, E.3
-
9
-
-
0024853567
-
Herpes simplex virus type 1 and human DNA polymerase interactions with 2-deoxyguanosine 5′-triphosphate analogs
-
Reardon JE. Herpes simplex virus type 1 and human DNA polymerase interactions with 2-deoxyguanosine 5′-triphosphate analogs. J Biol Chem 1989;264:19039-44.
-
(1989)
J Biol Chem
, vol.264
, pp. 19039-19044
-
-
Reardon, J.E.1
-
10
-
-
0023840835
-
Insertion and extension of acyclic, dideoxy, and Ara nucleotides by herpesviridae, human α and β polymerases
-
Reid R, Mar E, Huang E, Topal MD. Insertion and extension of acyclic, dideoxy, and Ara nucleotides by herpesviridae, human α and β polymerases. J Biol Chem 1988;263:3898-904.
-
(1988)
J Biol Chem
, vol.263
, pp. 3898-3904
-
-
Reid, R.1
Mar, E.2
Huang, E.3
Topal, M.D.4
-
11
-
-
0021860994
-
Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine and acyclovir in herpes simplex virus-infected and uninfected cells
-
Smee DF, Boehme RE, Chernow M, Binko BP, Matthews TR. Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)- guanine and acyclovir in herpes simplex virus-infected and uninfected cells. Biochem Pharmacol 1985;34:1049-56.
-
(1985)
Biochem Pharmacol
, vol.34
, pp. 1049-1056
-
-
Smee, D.F.1
Boehme, R.E.2
Chernow, M.3
Binko, B.P.4
Matthews, T.R.5
-
12
-
-
0031025998
-
Gene therapy for cancer: What have we done and where are we going?
-
Roth JA, Cristiano RJ. Gene therapy for cancer: what have we done and where are we going? J Nat Cancer Inst 1997;89:21-39.
-
(1997)
J Nat Cancer Inst
, vol.89
, pp. 21-39
-
-
Roth, J.A.1
Cristiano, R.J.2
-
13
-
-
0030742974
-
The role of the bystander effect in suicide gene therapy
-
Pope IM, Poston GJ, Kinsella AR. The role of the bystander effect in suicide gene therapy. Eur J Cancer 1997;33:1005-16.
-
(1997)
Eur J Cancer
, vol.33
, pp. 1005-1016
-
-
Pope, I.M.1
Poston, G.J.2
Kinsella, A.R.3
-
14
-
-
0027483695
-
The "bystander effect": Tumor regression when a fraction of the tumor mass is genetically modified
-
Freeman SM, Abboud CN, Whartenby KA, et al. The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993;53:5274-83.
-
(1993)
Cancer Res
, vol.53
, pp. 5274-5283
-
-
Freeman, S.M.1
Abboud, C.N.2
Whartenby, K.A.3
-
15
-
-
0035123128
-
Gene directed enzyme/prodrug therapy of cancer: Historical appraisal and future prospectives
-
Greco O, Dachs GU. Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives. J Cell Physiol 2001;187:22-36.
-
(2001)
J Cell Physiol
, vol.187
, pp. 22-36
-
-
Greco, O.1
Dachs, G.U.2
-
16
-
-
0030724139
-
Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes
-
Denning C, Pitts JD. Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes. Hum Gene Ther 1997;8:1825-35.
-
(1997)
Hum Gene Ther
, vol.8
, pp. 1825-1835
-
-
Denning, C.1
Pitts, J.D.2
-
17
-
-
0030996607
-
Mechanism of "bystander effect" killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment
-
Ishii-Morita H, Agbaria R, Mullen CA, et al. Mechanism of "bystander effect" killing in the herpes simplex thymidine kinase gene therapy model of cancer treatment. Gene Ther 1997;4:244-51.
-
(1997)
Gene Ther
, vol.4
, pp. 244-251
-
-
Ishii-Morita, H.1
Agbaria, R.2
Mullen, C.A.3
-
18
-
-
0027787053
-
In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy
-
Bi WL, Parysek LM, Warnick R, Stambrook PJ. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSVtk retroviral gene therapy. Hum Gene Ther 1993;4:725-31.
-
(1993)
Hum Gene Ther
, vol.4
, pp. 725-731
-
-
Bi, W.L.1
Parysek, L.M.2
Warnick, R.3
Stambrook, P.J.4
-
19
-
-
0029996360
-
Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins
-
Mesnil M, Piccoli C, Tiraby G, Willecke K, Yamasaki H. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc Natl Acad Sci U S A 1996;93:1831-5.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 1831-1835
-
-
Mesnil, M.1
Piccoli, C.2
Tiraby, G.3
Willecke, K.4
Yamasaki, H.5
-
20
-
-
0033900009
-
Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: Role of gap-junctional intercellular communication
-
Mesnil M, Yamasaki H. Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication. Cancer Res 2000;60:3989-99.
-
(2000)
Cancer Res
, vol.60
, pp. 3989-3999
-
-
Mesnil, M.1
Yamasaki, H.2
-
21
-
-
0031991630
-
Bystander tumoricidal effect and gap junctional communication in lung cancer cell lines
-
Imaizumi K, Hasegawa Y, Kawabe T, et al. Bystander tumoricidal effect and gap junctional communication in lung cancer cell lines. Am J Respir Cell Mol Biol 1998;18:205-12.
-
(1998)
Am J Respir Cell Mol Biol
, vol.18
, pp. 205-212
-
-
Imaizumi, K.1
Hasegawa, Y.2
Kawabe, T.3
-
22
-
-
0347926503
-
Gap junction-mediated bystander effect if primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene
-
Asklund T, Appelskog IB, Ammerpohl O, et al. Gap junction-mediated bystander effect if primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene. Exp Cell Res 2003;284:185-95.
-
(2003)
Exp Cell Res
, vol.284
, pp. 185-195
-
-
Asklund, T.1
Appelskog, I.B.2
Ammerpohl, O.3
-
23
-
-
0032502845
-
Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase
-
Boucher PD, Ruch RJ, Shewach DS. Differential ganciclovir-mediated cytotoxicity and bystander killing in human colon carcinoma cell lines expressing herpes simplex virus thymidine kinase. Hum Gene Ther 1998;9:801-14.
-
(1998)
Hum Gene Ther
, vol.9
, pp. 801-814
-
-
Boucher, P.D.1
Ruch, R.J.2
Shewach, D.S.3
-
24
-
-
0033082434
-
Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells
-
Rubsam LZ, Boucher PD, Murphy PJ, KuKuruga M, Shewach DS. Cytotoxicity and accumulation of ganciclovir triphosphate in bystander cells cocultured with herpes simplex virus type 1 thymidine kinase-expressing human glioblastoma cells. Cancer Res 1999;59:669-75.
-
(1999)
Cancer Res
, vol.59
, pp. 669-675
-
-
Rubsam, L.Z.1
Boucher, P.D.2
Murphy, P.J.3
Kukuruga, M.4
Shewach, D.S.5
-
25
-
-
0028278801
-
The role of gap junctional intercellular communication in neoplasia
-
Ruch RJ. The role of gap junctional intercellular communication in neoplasia. Ann Clin Lab Sci 1994;24:216-31.
-
(1994)
Ann Clin Lab Sci
, vol.24
, pp. 216-231
-
-
Ruch, R.J.1
-
26
-
-
0029913138
-
Gap junctions play a role in the "bystander effect" of the herpes simplex virus thymidine kinase/ganciclovir system in vitro
-
Elshami AA, Saavedra A, Zhang H, et al. Gap junctions play a role in the "bystander effect" of the herpes simplex virus thymidine kinase/ganciclovir system in vitro. Gene Ther 1996;3:85-92.
-
(1996)
Gene Ther
, vol.3
, pp. 85-92
-
-
Elshami, A.A.1
Saavedra, A.2
Zhang, H.3
-
27
-
-
0030937485
-
Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo
-
Dilber MS, Abedi MR, Christensson B, et al. Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo. Cancer Res 1997;57:1523-8.
-
(1997)
Cancer Res
, vol.57
, pp. 1523-1528
-
-
Dilber, M.S.1
Abedi, M.R.2
Christensson, B.3
-
28
-
-
85047699299
-
Connexin 43-mediated bystander effect in two rat glioma cell models
-
Sanson M, Marcaud V, Robin E, Valery C, Sturtz F, Zale B. Connexin 43-mediated bystander effect in two rat glioma cell models. Cancer Gene Ther 2002;9:149-55.
-
(2002)
Cancer Gene Ther
, vol.9
, pp. 149-155
-
-
Sanson, M.1
Marcaud, V.2
Robin, E.3
Valery, C.4
Sturtz, F.5
Zale, B.6
-
29
-
-
0033651048
-
Connexin 43-enhanced suicide gene therapy using herpes viral vectors
-
Marconi P, Tamura M, Moriuchi S, et al. Connexin 43-enhanced suicide gene therapy using herpes viral vectors. Mol Ther 2000;1:71-81.
-
(2000)
Mol Ther
, vol.1
, pp. 71-81
-
-
Marconi, P.1
Tamura, M.2
Moriuchi, S.3
-
30
-
-
85047698025
-
Purified herpes simplex virus thymidine kinase retroviral particles. III. Characterization of bystander killing mechanisms in transfected tumor cells
-
Burrows FJ, Gore M, Smiley WR, et al. Purified herpes simplex virus thymidine kinase retroviral particles. III. Characterization of bystander killing mechanisms in transfected tumor cells. Cancer Gene Ther 2002;9:87-95.
-
(2002)
Cancer Gene Ther
, vol.9
, pp. 87-95
-
-
Burrows, F.J.1
Gore, M.2
Smiley, W.R.3
-
31
-
-
0031693323
-
In vitro and in vivo effects of retrovirus-mediated transfer of connexin 43 gene in malignant gliomas: Consequences for HSVtk/GCV anticancer gene therapy
-
Cirenei N, Colombo BM, Mesnil M, Benedetti S, Yamasaki H, Finocchiaro G. In vitro and in vivo effects of retrovirus-mediated transfer of connexin 43 gene in malignant gliomas: consequences for HSVtk/GCV anticancer gene therapy. Gene Ther 1998;5:1221-6.
-
(1998)
Gene Ther
, vol.5
, pp. 1221-1226
-
-
Cirenei, N.1
Colombo, B.M.2
Mesnil, M.3
Benedetti, S.4
Yamasaki, H.5
Finocchiaro, G.6
-
32
-
-
4744372650
-
Modulation of the HSV-Tk/ganciclovir bystander effect by n-butyrate in glioblastoma: Correlation with gap-junction intercellular communication
-
Robe PA, Jolois O, N'Guyen M, et al. Modulation of the HSV-Tk/ganciclovir bystander effect by n-butyrate in glioblastoma: correlation with gap-junction intercellular communication. Int J Oncol 2004;25:187-92.
-
(2004)
Int J Oncol
, vol.25
, pp. 187-192
-
-
Robe, P.A.1
Jolois, O.2
N'Guyen, M.3
-
33
-
-
4744370942
-
HDACi phenybutyrate increases bystander killing of HSV-tk transfected glioma cells
-
Ammerpohl O, Thormeyer D, Khan Z, et al. HDACi phenybutyrate increases bystander killing of HSV-tk transfected glioma cells. Biochem Biophys Res Commun 2004;324:8-14.
-
(2004)
Biochem Biophys Res Commun
, vol.324
, pp. 8-14
-
-
Ammerpohl, O.1
Thormeyer, D.2
Khan, Z.3
-
34
-
-
0030801745
-
Retinoids augment the bystander effect in vitro and in vivo in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy
-
Park JY, Elshami AA, Amin K, Rizk N, Kaiser LR, Albelda SM. Retinoids augment the bystander effect in vitro and in vivo in herpes simplex virus thymidine kinase/ganciclovir-mediated gene therapy. Gene Ther 1997;4:909-17.
-
(1997)
Gene Ther
, vol.4
, pp. 909-917
-
-
Park, J.Y.1
Elshami, A.A.2
Amin, K.3
Rizk, N.4
Kaiser, L.R.5
Albelda, S.M.6
-
35
-
-
0032213438
-
Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions
-
Touraine RL, Vahanian N, Ramsey WJ, Blaese RM. Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions. Hum Gene Ther 1998;9:2385-91.
-
(1998)
Hum Gene Ther
, vol.9
, pp. 2385-2391
-
-
Touraine, R.L.1
Vahanian, N.2
Ramsey, W.J.3
Blaese, R.M.4
-
36
-
-
0034654516
-
Synergistic enhancement of herpes simplex virus thymidine kinase/ ganciclovir-mediated cytotoxicity by hydroxyurea
-
Boucher PD, Ostruszka LJ, Shewach DS. Synergistic enhancement of herpes simplex virus thymidine kinase/ ganciclovir-mediated cytotoxicity by hydroxyurea. Cancer Res 2000;60:1631-6.
-
(2000)
Cancer Res
, vol.60
, pp. 1631-1636
-
-
Boucher, P.D.1
Ostruszka, L.J.2
Shewach, D.S.3
-
37
-
-
28444471183
-
In vitro and in vivo enhancement of ganciclovir-mediated bystander cytotoxicity with gemcitabine
-
Boucher PD, Shewach DS. In vitro and in vivo enhancement of ganciclovir-mediated bystander cytotoxicity with gemcitabine. Mol Ther 2005;12:1064-71.
-
(2005)
Mol Ther
, vol.12
, pp. 1064-1071
-
-
Boucher, P.D.1
Shewach, D.S.2
-
38
-
-
0036045454
-
Hydroxyurea significantly enhances tumor growth delay in vivo with herpes simplex virus thymidine kinase/ ganciclovir gene therapy
-
Boucher PD, Ostruszka LJ, Murphy PJM, Shewach DS. Hydroxyurea significantly enhances tumor growth delay in vivo with herpes simplex virus thymidine kinase/ ganciclovir gene therapy. Gene Ther 2002;9:1023-30.
-
(2002)
Gene Ther
, vol.9
, pp. 1023-1030
-
-
Boucher, P.D.1
Ostruszka, L.J.2
Murphy, P.J.M.3
Shewach, D.S.4
-
39
-
-
0030750649
-
A tumor suppressor gene, Cx26, also mediates the bystander effect in HeLa cells
-
Mesnil M, Piccoli C, Yamasaki H. A tumor suppressor gene, Cx26, also mediates the bystander effect in HeLa cells. Cancer Res 1997;57:2929-32.
-
(1997)
Cancer Res
, vol.57
, pp. 2929-2932
-
-
Mesnil, M.1
Piccoli, C.2
Yamasaki, H.3
-
40
-
-
0035059979
-
Induction of a bystander effect in HeLa cells by using a bigenic vector carrying viral thymidine kinase and connexin 32 genes
-
Tanaka T, Yamasaki H, Mesnil M. Induction of a bystander effect in HeLa cells by using a bigenic vector carrying viral thymidine kinase and connexin 32 genes. Mol Carcinog 2001;30:176-80.
-
(2001)
Mol Carcinog
, vol.30
, pp. 176-180
-
-
Tanaka, T.1
Yamasaki, H.2
Mesnil, M.3
-
41
-
-
21744448680
-
GCV phosphates are transferred between HeLa cells despite lack of bystander cytotoxicity
-
Gentry BG, Im M, Boucher PD, Ruch RJ, Shewach DS. GCV phosphates are transferred between HeLa cells despite lack of bystander cytotoxicity. Gene Ther 2005;12:1033-41.
-
(2005)
Gene Ther
, vol.12
, pp. 1033-1041
-
-
Gentry, B.G.1
Im, M.2
Boucher, P.D.3
Ruch, R.J.4
Shewach, D.S.5
-
42
-
-
0028915946
-
Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells
-
Elfgang C, Eckert R, Lichtenberg-Frate H, et al. Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. J Cell Biol 1995;129:805-17.
-
(1995)
J Cell Biol
, vol.129
, pp. 805-817
-
-
Elfgang, C.1
Eckert, R.2
Lichtenberg-Frate, H.3
-
43
-
-
0344848624
-
Phototoxicity of the fluorescent membrane dyes PKH2 and PKH26 on the human hematopoietic KG1a progenitor cell line
-
Oh DJ, Lee GM, Francis K, Palsson BO. Phototoxicity of the fluorescent membrane dyes PKH2 and PKH26 on the human hematopoietic KG1a progenitor cell line. Cytometry 1999;36:312-8.
-
(1999)
Cytometry
, vol.36
, pp. 312-318
-
-
Oh, D.J.1
Lee, G.M.2
Francis, K.3
Palsson, B.O.4
-
44
-
-
0035865965
-
Stimulation of intercellular communication of poor-communicating cells by gap-junction-competent cells enhances the HSV-TK/GCV bystander effect in vitro
-
Tanaka T, Yamasaki H, Mesnil M. Stimulation of intercellular communication of poor-communicating cells by gap-junction-competent cells enhances the HSV-TK/GCV bystander effect in vitro. Int J Cancer 2001;91:538-42.
-
(2001)
Int J Cancer
, vol.91
, pp. 538-542
-
-
Tanaka, T.1
Yamasaki, H.2
Mesnil, M.3
-
45
-
-
0030916131
-
Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells
-
Wygoda MR, Wilson MR, Davis MA, Trosko JE, Rehemtulla A, Lawrence TS. Protection of herpes simplex virus thymidine kinase-transduced cells from ganciclovir-mediated cytotoxicity by bystander cells. Cancer Res 1997;57:1699-703.
-
(1997)
Cancer Res
, vol.57
, pp. 1699-1703
-
-
Wygoda, M.R.1
Wilson, M.R.2
Davis, M.A.3
Trosko, J.E.4
Rehemtulla, A.5
Lawrence, T.S.6
|