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Volumn 1, Issue 1, 2000, Pages 71-81

Connexin 43-Enhanced Suicide Gene Therapy Using Herpesviral Vectors

Author keywords

Bystander effect; thymidine kinase; connexin; HSV vector; gene therapy

Indexed keywords

ANTIVIRUS AGENT; CONNEXIN 43; GANCICLOVIR; THYMIDINE KINASE;

EID: 0033651048     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.1999.0008     Document Type: Article
Times cited : (65)

References (60)
  • 2
    • 0031963349 scopus 로고    scopus 로고
    • Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins
    • Andreansky S., He B., van Cott J., McGhee J., Markert J. M., Gillespie G. Y., Roizman B., Whitley R. J. Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins. Gene Ther. 5:1998;121-130.
    • (1998) Gene Ther. , vol.5 , pp. 121-130
    • Andreansky, S.1    He, B.2    Van Cott, J.3    McGhee, J.4    Markert, J.M.5    Gillespie, G.Y.6    Roizman, B.7    Whitley, R.J.8
  • 3
    • 0027378976 scopus 로고
    • Thymidine kinase-mediated killing of rat brain tumors
    • Barba D., Hardin J., Ray J., Gage F. H. Thymidine kinase-mediated killing of rat brain tumors. J. Neurosurg. 79:1993;729-735.
    • (1993) J. Neurosurg. , vol.79 , pp. 729-735
    • Barba, D.1    Hardin, J.2    Ray, J.3    Gage, F.H.4
  • 4
    • 0028323573 scopus 로고
    • Development of antitumor immunity for following thymidine kinase-mediated killing of experimental brain tumors
    • Barba D., Hardin J., Sadelain M., Gage F. H. Development of antitumor immunity for following thymidine kinase-mediated killing of experimental brain tumors. Proc. Natl. Acad. Sci. USA. 91:1994;4348-4352.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4348-4352
    • Barba, D.1    Hardin, J.2    Sadelain, M.3    Gage, F.H.4
  • 6
    • 0027787053 scopus 로고
    • In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HCV Tk retroviral gene therapy
    • Bi W. L., Parysek L. M., Warnick R., Stambrook P. J. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HCV Tk retroviral gene therapy. Hum. Gene. Ther. 4:1993;725-731.
    • (1993) Hum. Gene. Ther. , vol.4 , pp. 725-731
    • Bi, W.L.1    Parysek, L.M.2    Warnick, R.3    Stambrook, P.J.4
  • 7
    • 0028034286 scopus 로고
    • Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene
    • Boviatsis E. J., Park J. S., Sena-Esteves M., Kramm C. M., Chase M., Efird J. T., Wei M. X., Breakefield X. O., Chiocca E. A. Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene. Cancer Res. 15:1994;5745-5751.
    • (1994) Cancer Res. , vol.15 , pp. 5745-5751
    • Boviatsis, E.J.1    Park, J.S.2    Sena-Esteves, M.3    Kramm, C.M.4    Chase, M.5    Efird, J.T.6    Wei, M.X.7    Breakefield, X.O.8    Chiocca, E.A.9
  • 8
    • 0000696034 scopus 로고
    • Tumors of the central nervous system
    • Washington: Armed Forces Institute of Pathology. p. 59
    • Burger P., Scheithauer B. Tumors of the central nervous system. Atlas of Tumor Pathology. 1994;Armed Forces Institute of Pathology, Washington. p. 59.
    • (1994) Atlas of Tumor Pathology
    • Burger, P.1    Scheithauer, B.2
  • 10
    • 0028202066 scopus 로고
    • Gene therapy for brain tumors: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo
    • Chen S. H., Shine H. D., Goodman J. C., Grossman R. G., Woo S. L. Gene therapy for brain tumors: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. USA. 91:1994;3054-3057.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3054-3057
    • Chen, S.H.1    Shine, H.D.2    Goodman, J.C.3    Grossman, R.G.4    Woo, S.L.5
  • 11
    • 0031693323 scopus 로고    scopus 로고
    • In vitro and in vivo effects of retrovirus-mediated transfer of the connexin 43 gene in malignant gliomas: Consequences for HSVtk/GCV anticancer gene therapy
    • Cirenei N., Colombo B. M., Mesnil M., Benedetti B., Yamasaki H., Finocchiaro G. In vitro and in vivo effects of retrovirus-mediated transfer of the connexin 43 gene in malignant gliomas: Consequences for HSVtk/GCV anticancer gene therapy. Gene Ther. 5:1998;1221-1226.
    • (1998) Gene Ther. , vol.5 , pp. 1221-1226
    • Cirenei, N.1    Colombo, B.M.2    Mesnil, M.3    Benedetti, B.4    Yamasaki, H.5    Finocchiaro, G.6
  • 12
    • 0029161615 scopus 로고
    • The "bystander effect": Association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice
    • Colombo B. M., Benedetti S., Ottolenghi S., Mora M., Pollo B., Poli G., Finocchiaro G. The "bystander effect": Association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice. Hum. Gene Ther. 6:1995;763-772.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 763-772
    • Colombo, B.M.1    Benedetti, S.2    Ottolenghi, S.3    Mora, M.4    Pollo, B.5    Poli, G.6    Finocchiaro, G.7
  • 13
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
    • Culver K., Ram Z., Walbridge S., Ishii H., Oldfield E., Blaese R. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science. 256:1992;1550-1552.
    • (1992) Science , vol.256 , pp. 1550-1552
    • Culver, K.1    Ram, Z.2    Walbridge, S.3    Ishii, H.4    Oldfield, E.5    Blaese, R.6
  • 14
    • 0027521388 scopus 로고
    • Purification and biochemical characterization of the protein kinase encoded by the US3 gene of herpes simplex virus type 2
    • Daikoku T., Yamashita Y., Tsurumi T., Maeno K., Nishiyama Y. Purification and biochemical characterization of the protein kinase encoded by the US3 gene of herpes simplex virus type 2. Virology. 197:1993;685-694.
    • (1993) Virology , vol.197 , pp. 685-694
    • Daikoku, T.1    Yamashita, Y.2    Tsurumi, T.3    Maeno, K.4    Nishiyama, Y.5
  • 15
    • 0031680640 scopus 로고    scopus 로고
    • Combination gene delivery of the cell cycle inhibitor p27 with thymidine kinase enhances prodrug cytotoxicity
    • Danthinne X., Aoki K., Kurachi A., Nabel G., Nabel E. Combination gene delivery of the cell cycle inhibitor p27 with thymidine kinase enhances prodrug cytotoxicity. J. Virol. 72:1998;9201-9207.
    • (1998) J. Virol. , vol.72 , pp. 9201-9207
    • Danthinne, X.1    Aoki, K.2    Kurachi, A.3    Nabel, G.4    Nabel, E.5
  • 16
    • 0022358365 scopus 로고
    • Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4
    • DeLuca N. A., McCarthy A. M., Schaffer P. A. Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. J. Virol. 56:1985;558-570.
    • (1985) J. Virol. , vol.56 , pp. 558-570
    • Deluca, N.A.1    McCarthy, A.M.2    Schaffer, P.A.3
  • 17
    • 0021797441 scopus 로고
    • Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4
    • DeLuca N. A., Schaffer P. A. Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4. Mol. Cell. Biol. 5:1985;1997-2008.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 1997-2008
    • Deluca, N.A.1    Schaffer, P.A.2
  • 19
    • 0030809793 scopus 로고    scopus 로고
    • Dominant-negative abrogation of connexin-mediated cell growth control by mutant connexin genes
    • Duflot-Dancer A., Mesnil M., Yamasaki H. Dominant-negative abrogation of connexin-mediated cell growth control by mutant connexin genes. Oncogene. 15:1997;2151-2158.
    • (1997) Oncogene , vol.15 , pp. 2151-2158
    • Duflot-Dancer, A.1    Mesnil, M.2    Yamasaki, H.3
  • 21
    • 0025899005 scopus 로고
    • Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene
    • Ezzeddine Z. D., Martuza R. L., Platika D., Short M. P., Malick A., Choi B., Breakefield X. O. Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. New Biol. 3:1991;608-614.
    • (1991) New Biol. , vol.3 , pp. 608-614
    • Ezzeddine, Z.D.1    Martuza, R.L.2    Platika, D.3    Short, M.P.4    Malick, A.5    Choi, B.6    Breakefield, X.O.7
  • 22
    • 0029925070 scopus 로고    scopus 로고
    • Gene transfer to neurons using herpes simplex virus-based vectors
    • Fink D., DeLuca N., Goins W., Glorioso J. Gene transfer to neurons using herpes simplex virus-based vectors. Annu. Rev. Neurosci. 19:1996;265-287.
    • (1996) Annu. Rev. Neurosci. , vol.19 , pp. 265-287
    • Fink, D.1    Deluca, N.2    Goins, W.3    Glorioso, J.4
  • 25
  • 27
    • 0039818754 scopus 로고
    • Mechanism of "bystander effect" killing in the herpes simplex thymidine kinase into glioma cells targeting of gancyclovir cytotoxic effect
    • Ishii H. Mechanism of "bystander effect" killing in the herpes simplex thymidine kinase into glioma cells targeting of gancyclovir cytotoxic effect. Neurol. Med. Chir. (Tokyo). 34:1994;1094-1102.
    • (1994) Neurol. Med. Chir. (Tokyo) , vol.34 , pp. 1094-1102
    • Ishii, H.1
  • 28
    • 0028235166 scopus 로고
    • Retroviral transfer of herpes simplex thymidine kinase into glioma cells targeting of gancyclovir cytotoxic effect
    • Kato K., Yoshida J., Mizuno M., Sugita K., Emi N. Retroviral transfer of herpes simplex thymidine kinase into glioma cells targeting of gancyclovir cytotoxic effect. Neurol. Med. Chir. (Tokyo). 34:1994;339-344.
    • (1994) Neurol. Med. Chir. (Tokyo) , vol.34 , pp. 339-344
    • Kato, K.1    Yoshida, J.2    Mizuno, M.3    Sugita, K.4    Emi, N.5
  • 31
    • 0032427040 scopus 로고    scopus 로고
    • Deletion of multiple immediate early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons
    • Krisky D. M., Wolfe D., Goins W. F., Marconi P. C., Ramakrishnan R., Mata M., Rouse R. J. D., Fink D. J., Glorioso J. C. Deletion of multiple immediate early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons. Gene Ther. 5:1998;1593-1603.
    • (1998) Gene Ther. , vol.5 , pp. 1593-1603
    • Krisky, D.M.1    Wolfe, D.2    Goins, W.F.3    Marconi, P.C.4    Ramakrishnan, R.5    Mata, M.6    Rouse, R.J.D.7    Fink, D.J.8    Glorioso, J.C.9
  • 32
    • 0030701975 scopus 로고    scopus 로고
    • Combination therapy with suicide and cytokine genes for hepatic metastases of lung cancer
    • Kwong Y., Chen S., Kosai K., Finegold M., Woo S. Combination therapy with suicide and cytokine genes for hepatic metastases of lung cancer. Chest. 112:1997;1332-1337.
    • (1997) Chest , vol.112 , pp. 1332-1337
    • Kwong, Y.1    Chen, S.2    Kosai, K.3    Finegold, M.4    Woo, S.5
  • 34
    • 0022471218 scopus 로고
    • Growth inhibition of transformed cells correlates with their junctional communication with normal cells
    • Mehta P. P., Bertram J. S., Loewenstein W. R. Growth inhibition of transformed cells correlates with their junctional communication with normal cells. Cell. 44:1986;187-196.
    • (1986) Cell , vol.44 , pp. 187-196
    • Mehta, P.P.1    Bertram, J.S.2    Loewenstein, W.R.3
  • 35
    • 0029996360 scopus 로고    scopus 로고
    • Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins
    • Mesnil M., Piccoli C., Tiraby G., Willecke K., Yamasaki H. Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins. Proc. Natl. Acad. Sci. USA. 93:1996;1831-1835.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1831-1835
    • Mesnil, M.1    Piccoli, C.2    Tiraby, G.3    Willecke, K.4    Yamasaki, H.5
  • 36
    • 0030750649 scopus 로고    scopus 로고
    • A tumor suppressor gene, Cx26, also mediates the bystander effect in HeLa cells
    • Mesnil M., Piccoli C., Yamasaki H. A tumor suppressor gene, Cx26, also mediates the bystander effect in HeLa cells. Cancer Res. 57:1997;2929-2932.
    • (1997) Cancer Res. , vol.57 , pp. 2929-2932
    • Mesnil, M.1    Piccoli, C.2    Yamasaki, H.3
  • 37
    • 0022485359 scopus 로고
    • Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy
    • Moolten F. L. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy. Cancer Res. 46:1986;5276-5281.
    • (1986) Cancer Res. , vol.46 , pp. 5276-5281
    • Moolten, F.L.1
  • 38
    • 0032535495 scopus 로고    scopus 로고
    • Enhanced tumor-cell killing in the presence of ganciclovir by HSV-1 vector-directed co-expression of human TNF-a and HSV thymidine kinase
    • Moriuchi S., Oligino T., Krisky D., Marconi P., Fink D., Cohen J., Glorioso J. C. Enhanced tumor-cell killing in the presence of ganciclovir by HSV-1 vector-directed co-expression of human TNF-a and HSV thymidine kinase. Cancer Res. 58:1998;5731-5737.
    • (1998) Cancer Res. , vol.58 , pp. 5731-5737
    • Moriuchi, S.1    Oligino, T.2    Krisky, D.3    Marconi, P.4    Fink, D.5    Cohen, J.6    Glorioso, J.C.7
  • 39
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 40
    • 0026687364 scopus 로고
    • In vivo growth of C6 glioma cells transfected with connexin43 cDNA
    • Naus C., Elisevich K., Zhu D., Belliveau D., Del Maestro R. In vivo growth of C6 glioma cells transfected with connexin43 cDNA. Cancer Res. 52:1992;4208-4213.
    • (1992) Cancer Res. , vol.52 , pp. 4208-4213
    • Naus, C.1    Elisevich, K.2    Zhu, D.3    Belliveau, D.4    Del Maestro, R.5
  • 41
    • 0026090172 scopus 로고
    • Gap junction gene expression in human seizure disorder
    • Naus C. C., Bechberger J. F., Paul D. L. Gap junction gene expression in human seizure disorder. Exp. Neurol. 111:1991;198-203.
    • (1991) Exp. Neurol. , vol.111 , pp. 198-203
    • Naus, C.C.1    Bechberger, J.F.2    Paul, D.L.3
  • 43
    • 0029870613 scopus 로고    scopus 로고
    • Combination gene therapy for oral cancer in a murine model
    • O'Malley B., Cope K., Chen S., Li D., Schwarta M., Woo S. Combination gene therapy for oral cancer in a murine model. Cancer Res. 56:1996;1737-1741.
    • (1996) Cancer Res. , vol.56 , pp. 1737-1741
    • O'Malley, B.1    Cope, K.2    Chen, S.3    Li, D.4    Schwarta, M.5    Woo, S.6
  • 44
    • 0032991779 scopus 로고    scopus 로고
    • Effective cytokine gene therapy against an intracranial glioma using a retrovirally transduced IL-4 plus HSVtk tumor vaccine
    • Okada H., Giezeman-Smits K., Tahara H., Attanucci J., Fellows W., Lotze M., Chambers W., Bozik M. Effective cytokine gene therapy against an intracranial glioma using a retrovirally transduced IL-4 plus HSVtk tumor vaccine. Gene Ther. 6:1999;219-226.
    • (1999) Gene Ther. , vol.6 , pp. 219-226
    • Okada, H.1    Giezeman-Smits, K.2    Tahara, H.3    Attanucci, J.4    Fellows, W.5    Lotze, M.6    Chambers, W.7    Bozik, M.8
  • 47
    • 0040411314 scopus 로고
    • In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats
    • Ram Z., Culver K. W., Walbridge S., Blaese R. M., Oldfield E. H. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res. 46:1986;5276-5281.
    • (1986) Cancer Res. , vol.46 , pp. 5276-5281
    • Ram, Z.1    Culver, K.W.2    Walbridge, S.3    Blaese, R.M.4    Oldfield, E.H.5
  • 48
    • 0028071271 scopus 로고
    • The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats
    • Ram Z., Wallbridge S., Shawker T., Culver K. W., Blaese R. M., Oldfield E. H. The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats. J. Neurosurg. 81:1994;256-260.
    • (1994) J. Neurosurg. , vol.81 , pp. 256-260
    • Ram, Z.1    Wallbridge, S.2    Shawker, T.3    Culver, K.W.4    Blaese, R.M.5    Oldfield, E.H.6
  • 50
    • 0030773904 scopus 로고    scopus 로고
    • Deletion of the S component inverted repeat sequence c′ and the nonessential genes Us1 through Us5 from the herpes simplex virus type 1 genome substantially impairs productive viral infection in cell culture and pathogenesis in the rat central nervous system
    • Rasty S., Poliani P., Fink D., Glorioso J. Deletion of the S component inverted repeat sequence c′ and the nonessential genes Us1 through Us5 from the herpes simplex virus type 1 genome substantially impairs productive viral infection in cell culture and pathogenesis in the rat central nervous system. J. Neurovirol. 3:1997;247-264.
    • (1997) J. Neurovirol. , vol.3 , pp. 247-264
    • Rasty, S.1    Poliani, P.2    Fink, D.3    Glorioso, J.4
  • 51
    • 0030958819 scopus 로고    scopus 로고
    • The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27
    • Samaniego L., Wu N., DeLuca N. A. The herpes simplex virus immediate-early protein ICP0 affects transcription from the viral genome and infected-cell survival in the absence of ICP4 and ICP27. J. Virol. 71:1997;4614-4625.
    • (1997) J. Virol. , vol.71 , pp. 4614-4625
    • Samaniego, L.1    Wu, N.2    Deluca, N.A.3
  • 52
    • 0031947861 scopus 로고    scopus 로고
    • Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins
    • Samaniego L. A., Neiderhiser L., DeLuca N. A. Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins. J. Virol. 72:1998;3307-3320.
    • (1998) J. Virol. , vol.72 , pp. 3307-3320
    • Samaniego, L.A.1    Neiderhiser, L.2    Deluca, N.A.3
  • 55
    • 0032213438 scopus 로고    scopus 로고
    • Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions
    • Touraine R. L., Vahanian N., Ramsey W. J., Blaese R. M. Enhancement of the herpes simplex virus thymidine kinase/ganciclovir bystander effect and its antitumor efficacy in vivo by pharmacologic manipulation of gap junctions. Hum. Gene Ther. 9:1998;2385-2391.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 2385-2391
    • Touraine, R.L.1    Vahanian, N.2    Ramsey, W.J.3    Blaese, R.M.4
  • 56
    • 0030757097 scopus 로고    scopus 로고
    • The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions
    • Vrionis F. D., Wu J. K., Qi P., Waltzman M., Cherington V., Spray D. C. The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions. Gene Ther. 4:1997;577-585.
    • (1997) Gene Ther. , vol.4 , pp. 577-585
    • Vrionis, F.D.1    Wu, J.K.2    Qi, P.3    Waltzman, M.4    Cherington, V.5    Spray, D.C.6
  • 57
  • 58
    • 0029793857 scopus 로고    scopus 로고
    • Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22
    • Wu N., Watkins S. C., Schaffer P. A., DeLuca N. A. Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22. J. Virol. 70:1996;6358-6368.
    • (1996) J. Virol. , vol.70 , pp. 6358-6368
    • Wu, N.1    Watkins, S.C.2    Schaffer, P.A.3    Deluca, N.A.4
  • 59
    • 0030250227 scopus 로고    scopus 로고
    • Role of disrupted gap junctional intercellular communication in detection and characterization of carcinogens
    • Yamasaki H. Role of disrupted gap junctional intercellular communication in detection and characterization of carcinogens. Mutat. Res. 365:1996;91-105.
    • (1996) Mutat. Res. , vol.365 , pp. 91-105
    • Yamasaki, H.1
  • 60
    • 0025972397 scopus 로고
    • Transfection of C6 glioma cells with connexin 43 cDNA: Analysis of expression, intercellular coupling, and cell proliferation
    • Zhu D., Caveney S., Kidder G. M., Naus C. C. Transfection of C6 glioma cells with connexin 43 cDNA: Analysis of expression, intercellular coupling, and cell proliferation. Proc. Natl. Acad. Sci. USA. 88:1991;1883-1887.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1883-1887
    • Zhu, D.1    Caveney, S.2    Kidder, G.M.3    Naus, C.C.4


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