Halting neuroblastoma metastasis by controlling integrin-mediated death

Cell Cycle

Volumn 5, Issue 7, 2006, Pages 681-685

  Teitz, Tal ^a   Stupack, Dwayne G ^b   Lahti, Jill M ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Caspase 8; Integrin mediated death; Metastasis; Neuroblastoma; 1 integrins

Indexed keywords

CASPASE 8; INTEGRIN; VERY LATE ACTIVATION ANTIGEN 3;

BIOPSY; CARCINOGENESIS; DEATH; GENE EXPRESSION; HUMAN; METASTASIS; MICROENVIRONMENT; NEUROBLASTOMA; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SURVIVAL; TUMOR CELL; UPREGULATION;

MURINAE;

EID: 33645710020     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.7.2615     Document Type: Review

References (43)

1. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevchenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME, Dixit VM. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signaling complex. Cell 1996; 85:817-27.
2. Varfolomeev EE, Schuchmann M, Lauria V, Chiannikulchai N, Beckmann JS, Mett IL, Rebrikov D, Brodianski VM, Kemper OC, Kollet O, et al. Targeted distruption of the mouse caspase-8 gene ablates cell death induction by the TNF receptors, Fas/Apo1 and DR3 and is lethal prenatally. Immunity 1998; 9:267-76.
3. Kang TB, Ben-Moshe T, Varfolomeev EE, Pewzner-Jung Y, Yogev N, Jurewicz A, Waisman A, Brenner O, Haffner R, Gustafsson E, Ramakrishnan P, Lapidot T, Wallach D. Caspase-8 serves both apoptotic and nonapoptotic roles. J Immunol 2004; 173:2976-84.
4. Tang D, Lahti JM, Kidd VJ. Caspase-8 activation and Bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis. J Biol Chem 2000; 275:9303-7.
5. Engels IH, Stepczynska A, Stroh C, Lauber K, Berg C, Schwenzer R, Wajant H, Janicke RU, Porter AG, Belka C, Gregor M, Schulze-Osthoff K, Wesselborg S. Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis. Oncogene 2000; 19:4563-73.
6. Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB, Korsmeyer SJ. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev 2000; 14:2060-71.
7. Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ. Caspase-8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med 2000; 6:529-35.
8. Hopkins-Donaldson S, Bodmer JL, Bourloud KB, Brognara CB, Tschopp J, Gross N. Loss of caspase-8 expression in neuroblastoma is related to malignancy and resistance to TRAIL-induced apoptosis. Med Pediatr Oncol 2000; 35:608-11.
9. Eggert A, Grotzer MA, Zuzak TJ, Wiewrodt BR, Ikegaki N, Brodeur GM. Resistance to TRAIL-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression. Med Pediatr Oncol 2000; 35:603-7.
10. Fulda S, Kufer MU, Meyer E, van Valen F, Dockhorn-Dworniczak B, Debatin KM. Sensitization for death-receptor-or drug-induced apoptosis by reexpression of caspase-8 through demethylation or gene transfer. Oncogene 2001; 20:5865-77.
11. Takita J, Yang HW, Chen YY, Hanada R, Yamamoto K, Teitz T, Kidd VJ, Hayashi Y. Allelic imbalance on chromosome 2q and alterations of the caspase 8 gene in neuroblastoma. Oncogene 2001; 20:4424-32.
12. Grotzer MA, Eggert A, Zuzak TZ, Janss AJ, Marwaha S, Wiewrodt BR, Ikegaki N, Brodeur GM, Phillips PC. Resistance to TRAIL-induced apopotosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression. Oncogene 2000; 19:4604-10.
13. Teitz T, Lahti JM, Kidd VJ. Aggressive childhood neuroblastoma do not express caspase-8: An important component of programmed cell death. J Mol Med 2001; 79:428-36.
14. Harada K, Toyooka S, Shivapurkar N, Maitra A, Reddy JL, Matta H, Miyajima K, Timmons CF, Tomlinson GE, Mastrangelo D, Hay RJ, Chaudhary PM, Gazdar AF. Deregulation of Caspase-8 and 10 expression in pediatric tumors and cell lines. Cancer Res 2002; 62:5897-901.
15. Hopkins-Donalson S, Ziegler A, Kurtz S, Bigosch C, Kandioler D, Ludwig C, Zangemeister-Wittke U, Stahel R. Silencing of death-receptor and caspase-8 expression in small cell lung carcinoma cell lines and tumors by DNA methylation. Cell Death Differ 2003; 10356-64.
16. Pingoud-Meier C, Lang D, Janss AJ, Rorke, LB, Philipps PC, Shalaby T, Grotzer MA. Loss of caspase-8 protein expression correlates with unfavorable survival outcome in childhood medulloblastoma. Clinical Cancer Res 2003; 9:6401-9.
17. Rozzo C, Cheisa V, Caridi G, Pagnan G, Ponzoni M. Induction of apoptosis in human neuroblastoma cells by abrogation of integrin-mediated cell adhesion. Int J Cancer 1997; 70:688-98.
18. Stupack DG, Cheresh DA. Get a ligand, get a life: Integrins, signaling and cells survival. J Cell Science 2002; 115:3729-38.
19. Ruoslahti E, Reed JC. Anchorage dependence, integrins and apoptosis. Cell 1994; 77:47-78.
20. Schwartz MA, Ginsberg MH. Networks and crosstalk: Integrin signaling spreads. Nat Cell Biol 2000; 4:E65-8.
21. Giancotti FG, Tarone G. Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu Rev Cell Dev Bio 2003; 19:173-206.
22. Playford MP, Schaller MD. The interplay between Src and integrins in normal and tumor biology. Oncogene 2004; 23:7928-46.
23. Stupack DG, Puente XS, Boutsaboualoy S, Storgard CM, Cheresh DA. Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J Cell Biol 2001; 155:459-70.
24. Marconi A, Atzei P, Panza C, Fila C, Tiberio R, Truzzi F, Wachter T, Leverkus M, Pincelli C. Flice/caspase-8 activation triggers anoikis induced by β1-integrin blockade in human kertinocytes. J Cell Sci 2004; 117:5815-23.
25. Stupack DG, Teitz T, Potter MD, Mikolon D, Houghton PJ, Kidd VJ, Lahti JM, Cheresh DA. Potentiation of neuroblastoma metastasis by loss of caspase-8. Nature 2006; 439:95-99.
26. Teitz T, Wei T, Liu D, Valentine V, Valentine M, Grenet J, Lahti JM, Kidd VJ. Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN. Oncogene 2002; 21:1848-58.
27. Norris MD, Burkhart CA, Marshall GM, Weiss WA, Haber M. Expression of N-MYC and MRP genes and their relationship to N-MYC gene dosage and tumor formation in a murine neuroblastoma model. Med Pediatr Oncol 2000; 35:585-9.
28. Blanc E, Goldschneider D, Ferrandis E, Barrois M, Le Roux G, Leonce S, Douc-Rasy S, Benard J, Raguenez G. MYCN enhances P-gp/MDR1 gene expression in the human metastatic neuroblastoma IGR-N-91 model. Am J Pathol 2003; 163:321-331.
29. Thomas SK, Messam CA, Spengler BA, Biedler JL, Ross RA. Nestin is a potential mediator of malignancy in human neuroblastoma cells. J Biol Biochem 2004; 279:27994-9.
30. Yang Q, Liu S, Tian Y, Salwen HR, Chlenski A, Weinstein J, Cohn SL. Methylation-associated silencing of the Thrombospondin-1 gene in human neuroblastoma. Cancer Res 2003; 63:6299-10.
31. Favrot MC, Combaret V, Goillot E, Lutz P, Frappaz D, Thiesse P, Thyss A, Dolbeau D, Bouffet E, Talbone E, et al. Expression of integrin receptors on 45 clinical neuroblastoma specimens. Int J Cancer 1991; 49:347-55.
32. Judware R, Lechner R, Culp LA. Inverse expressions of the N-MYC oncogene and beta 1 integrin in human neuroblastoma: Relationships to disease progression in a nude mouse model system. Clin Exp Metastasis 1995; 13:123-33.
33. Judware R, Culp LA. Concomitant downregulation of expression of integrin subunits by N-MYC in human neuroblastoma cells: Differential regulation of α2, α3 and β1. Oncogene 1997; 14:1341-50.
34. Gelman MS, Ye XK, Stull R, Suhy D, Jin L, Ng D, Than B, Ji M, Pan A, Perez P, Sun Y, Yeung P, Garcia LM, Harte R, Lu Y, Lamar E, Tavassoli R, Kennedy S, Osborn S, Chin DJ, Meshaw K, Holzmayer TA, Axenovich SA, Abo A. Identification of cell surface and secreted proteins essential for tumor cell survival using a genetic suppressor element screen. Oncogene 2004; 23:8158-70.
35. Stegh AH, Herrmann H, Lampel S, Weisenberger D, Andra K, Seper M, Wiche G, Krammer PH, Peter ME. Identification of the Cytolinker Plectin as a major early in vivo substrate for caspase-8 during CD95- and tumor necrosis factor receptor-mediated apoptosis. Mol Cell Biol 2002; 20:5665-79.
36. Fischer U, Janicke RU, Schulze-Osthoff K. Many cuts to ruin: A comprehensive update of caspase substrates. Cell Death and Differentiation 2003; 10:76-100.
37. Watanabe Y, Akaike T. Possible involvement of caspase-like family in maintenance of cytoskeleton integrity. J Cell Physiol 199; 179:45-51.
38. Antonopoulos C, Cumberbatch M, Dearman RJ, Daniel RJ, Kimber I, Groves RW. Functional caspase-1 is required for Langerhans cell migration and optimal contact sensitization in mice. J Immunol 2001; 166:3672-7.
39. Barnhart BC, Legembre P, Pietras E, Bubici C, Franzoso G, Peter ME. CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells. EMBO J 2004; 23:3175-85.
40. Vidal M, Larson DE, Cagan RL. Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration and apoptosis. Dev Cell 2006; 10:33-44.
41. Calderwood DA, Huttenlocher A, Kiosses WB, Rose DM, Woodside DG, Schwartz MA, Ginsberg MH. Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration. Nat Cell Biol 2001; 3:1060-8.
42. Stupack DG, Li E, Silletti SA, Kehler JA, Geahlen RL, Hahn K, Nemerow GR, Cheresh DA. Matrix valency regulates integrin-mediated lymphoid adhesionvia Syk Kinase. J Cell Biol 1999; 144:777-88.
43. Smith BE, Bradshaw AD, Choi ES, Rouselle P, Wayner EA, Clegg DO. Human SY5Y neuroblastoma cell interactions with laminin isoforms: Neurite outgrowth on laminin-5 is mediated by integrin alpha 3 beta 1. Cell Adhes Commun 1996; 3:451-62.