Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration

Nature Cell Biology

Volumn 3, Issue 12, 2001, Pages 1060-1068

  Calderwood, David A ^a   Huttenlocher, Anna ^b   Kiosses, William B ^a   Rose, David M ^a   Woodside, Darren G ^a   Schwartz, Martin A ^a   Ginsberg, Mark H ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BETA1 INTEGRIN; CYTOPLASM PROTEIN; FIBRONECTIN; FILAMIN; INTEGRIN RECEPTOR; TALIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL ADHESION; CELL MEMBRANE; CELL MIGRATION; CELL POLARITY; CONTROLLED STUDY; CYTOPLASM; CYTOSKELETON; EXTRACELLULAR MATRIX; MIGRATION INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANIMALIA; METAZOA;

EID: 0035202874     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1201-1060     Document Type: Article

References (50)

1. Structure of integrin, a glycoprotein involved in transmembrane linkage between fibronectin and actin
2. Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity
3. Effects of cytochalasin B and colchicine on attachment of a major surface protein of fibroblasts
4. Integrin activation and cytoskeletal interaction are essential for the assembly of a fibronectin matrix
5. 1 cytoplasmic domain implicated in cytoskeletal association
6. 1 integrin subunit in vitro
7. Integrin β cytoplasmic domains differentially bind to cytoskeletal proteins
8. Interaction of plasma membrane fibronectin receptor with talin - A transmembrane linkage
9. Integrins and actin filaments: Reciprocal regulation of cell adhesion and signaling
10. Focal adhesions - The cytoskeletal connection
11. Native talin is a dumbbell-shaped homodimer when it interacts with actin
12. Structure of the α-actinin rod: Molecular basis for cross-linking of actin filaments
13. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): A molecular leaf spring
14. Integrin cytoplasmic domain-binding proteins
15. 1D integrin reinforces the cytoskeleton-matrix link: Modulation of integrin adhesive function by alternative splicing
16. 2-integrin subunit CD18
17. 2 cytoplasmic tail. Activation-dependent regulation of associations with talin and α-actinin
18. Filamins as integrators of cell mechanics and signalling
19. Structural and functional aspects of filamins
20. Breaking the integrin hinge: A defined structural constraint regulates integrin signaling
21. Filamin, a new high-molecular-weight protein found in smooth muscle and non-muscle cells
22. Binding and distribution of fluorescently labeled filamin in permeabilized and living cells
23. Selective inhibition of fibronectin-mediated cell adhesion by monoclonal antibodies to a cell-surface glycoprotein
24. Integrin cytoplasmic domains mediate inside-out signal transduction
25. 1 integrin cytoplasmic domain sequences critical for integrin function
26. Cell migration: A physically integrated molecular process
27. Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the Roundabout receptor
28. Negative regulation of fibroblast motility by Ena/VASP proteins
29. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-α activation of SAPK in melanoma cells
30. The Rac1- and RhoG-specific GEF domain of trio targets filamin to remodel cytoskeletal actin
31. The small GTPase RalA targets filamin to induce filopodia
32. Actin-binding protein requirement for cortical stability and efficient locomotion
33. Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia
34. Role of actin-binding protein in insertion of adhesion receptors into the membrane
35. PHD: Predicting one-dimensional protein structure by profile-based neural networks
36. A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants
37. Distinct functions of integrin α and β subunit cytoplasmic domains in cell spreading and formation of focal adhesions
38. 3 binding to α-actinin
39. 1-integrin. Identification of amino acids responsible for this interaction
40. 1 integrin cytoplasmic domain: Toward an understanding of function and mechanism
41. The role of actin-binding protein 280 in integrin-dependent mechanoprotection
42. Indications for a novel muscular dystrophy pathway. γ-Filamin, the muscle-specific filamin isoform, interacts with myotilin
43. 3 to lamellipodia in endothelial cell migration
44. 4 integrins is cell-type specific and activation dependent and is disrupted during apoptosis in T cells
45. Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway
46. 4 integrins modifies integrin-dependent biological responses
47. The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation
48. A role for p21-activated kinase in endothelial cell migration
49. Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPases
50. Altered rate of fibronectin matrix assembly by deletion of the first type III repeats