Recent uses of sol-gel doped catalysts in the fine chemicals and pharmaceutical industry

Organic Process Research and Development

Volumn 10, Issue 2, 2006, Pages 320-326

  Ciriminna, Rosaria ^a   Pagliaro, Mario ^a  

^a CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33645538816     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op050211u     Document Type: Review

References (29)

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6. Detailed information on the technology and its applications are available at the URL: http://www.reaxa.co.uk.
7. -1). The fiber are commercalised by Johnson Matthey in a variety of lengths (0.25 mm is standard), giving materials with different physical characteristics suited to a variety of reactor and filter combinations. One example is: Gilhespy, M.; Lok; M.; Baucherel, X. Chem. Commun. 2005, 1085.
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12. These advantages include fast kinetics (silica is surface functionalised and reacts much faster than conventional polymer-bound reagents where the reaction is slowed by the rate of diffusion through the polymer and can be slowed further by the polymer ability to swell); versatility (works under a wide range of conditions: in all solvents, organic and aqueous. It has a high thermal stability and can be used in microwave applications); and ease of use (unlike polymer, silica is easy to weigh and handle with no static issues and is easily amendable to automation. It is mechanically stable, works in any format, and is easily scaled. It requires little or no washing because it does not swell in any solvent). The Canada-based company SiliCycle Inc., for instance, commercialises a vast variety of functionalised silica gels as advanced reagents of the pharmaceutical and fine chemicals industry.
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22. 2O, the yields (and op) of the resulting (+)-2-methylsuccinic acid in the first four runs of 24 h were 100 (52), 98 (50), 95 (46), and 90% (41%), respectively.
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