Erythroid inhibition by the leukemic fusion AML1-ETO is associated with impaired acetylation of the major erythroid transcription factor GATA-1

Cancer Research

Volumn 66, Issue 6, 2006, Pages 2990-2996

  Choi, Youngjin ^a   Elagib, Kamaleldin E ^a   Delehanty, Lorrie L ^a   Goldfarb, Adam N ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; HYBRID PROTEIN; PROTEIN AML1 ETO; PROTEIN P300; TRANSCRIPTION FACTOR GATA 1; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACETYLATION; ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; ERYTHROID CELL; GENETIC TRANSFECTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETYLATION; ANTIGENS, CD34; ANTIGENS, CD36; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CORE BINDING FACTOR ALPHA 2 SUBUNIT; ERYTHROID PROGENITOR CELLS; GATA1 TRANSCRIPTION FACTOR; HUMANS; K562 CELLS; ONCOGENE PROTEINS, FUSION; P300-CBP TRANSCRIPTION FACTORS; TRANS-ACTIVATION (GENETICS); TRANSFECTION; ZINC FINGERS;

EID: 33645524703     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2944     Document Type: Article

References (50)

1. Brunning RD, McKenna RW. Acute myeloid leukemias. In. Tumors of the bone marrow. 1st ed. vol. 9. Washington (DC): Armed Forces Institute of Pathology; 1994. pp. 22-100.
2. Yamasaki H, Era T, Asou N, et al. High degree of myeloid differentiation and granulocytosis is associated with t(8;21) smoldering leukemia. Leukemia 1995;9:1147-53.
3. Kojima K, Omoto E, Hara M, et al. Myelodysplastic syndrome with translocation (8;21): a distinct myelodysplastic syndrome entity or M2-acute myeloid leukemia with extensive myeloid maturation? Ann Hematol 1998; 76:279-82.
4. Miyamoto T, Nagafuji K, Akashi K, et al. Persistence of multipotent progenitors expressing AML1/ETO transcripts in long-term remission patients with t(8;21) acute myelogenous leukemia. Blood 1996;87:4789-96.
5. Miyamoto T, Weissman IL, Akashi K. AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc Natl Acad Sci U S A 2000;97:7521-6.
6. Schwieger M, Lohler J, Friel J, Scheller M, Horak I, Stocking C. AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. J Exp Med 2002;196:1227-40.
7. Fenske TS, Pengue G, Mathews V, et al. Stem cell expression of the AML1/ETO fusion protein induces a myeloproliferative disorder in mice. Proc Natl Acad Sci USA 2004;101:15184-9.
8. Le XF, Claxton D, Kornblau S, Fan YH, Mu ZM, Chang KS. Characterization of the ETO and AML1-ETO proteins involved in 8;21 translocation in acute myelogenous leukemia. Eur J Haematol 1998;60:217-25.
9. Harada Y, Harada H, Downing JR, Kimura A. A hematopoietic-specific transmembrane protein, Art-1, is possibly regulated by AML1. Biochem Biophys Res Commun 2001;284:714-22.
10. Tonks A, Pearn L, Tonks AJ, et al. The AML1-ETO fusion gene promotes extensive self-renewal of human primary erythroid cells. Blood 2002;101:624-32.
11. Elagib KE, Racke FK, Mogass M, Khetawat R, Delehanty LL, Goldfarb AN. RUNX-1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation. Blood 2003;101:4333-41.
12. Ichikawa M, Asai T, Saito T, et al. AML1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nature Med 2004;10:299-304.
13. Peterson LF, Zhang D-E. The 8;21 translocation in leukemogenesis. Oncogene 2004;23:4255-62.
14. Tracey WD, Speck NA. Potential roles for RUNXI and its orthologs in determining hematopoietic cell fate. Semin Cell Dev Biol 2000;11:337-42.
15. Johnstone RW, Licht JD. Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? Cancer Cell 2003;4:13-8.
16. Yan M, Burel SA, Peterson LF, et al. Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development. Proc Natl Acad Sci U S A 2004;101:17186-91.
17. Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD. AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein. Blood 2000;96:3939-47.
18. Chevallier N, Corcoran CM, Lennon C, et al. ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein. Blood 2004;103:1454-63.
19. McGhee L, Bryan J, Elliott L, et al. Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism. J Cell Biochem 2003;89:1005-18.
20. Amann JM, Nip J, Strom DK, et al. ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSinSA through its oligomerization domain. Mol Cell Biol 2001;21:6470-83.
21. Barseguian K, Lutterbach B, Hiebert SW, et al. Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO represser proteins. Proc Natl Acad Sci U S A 2002;99:15434-9.
22. Liu S, Shen T, Huynh L, et al. Interplay of RUNX1/MTG8 and DNA methyltransferase I in acute myeloid leukemia. Cancer Res 2005;65:1277-84.
23. Shimada H, Ichikawa H, Nakamura S, et al. Analysis of genes under the downstream control of the t(8;21) fusion protein AML1-8: overexpression of the TISI1b (ERF-1, cMG1) gene induces myeloid cell proliferation in response to G-CSF. Blood 2000;96:655-63.
24. Waltzer L, Ferjoux G, Bataille L, Haenlin M. Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis. EMBO J 2003;22:6516-25.
25. Boyes J, Byfield P, Nakatani Y, Ogryzko V. Regulation of activity of the transcription factor GATA-1 by acetylation. Nature 1998;396:594-8.
26. Hung H-L, Lau J, Kim AY, Weiss MJ, Blobel GA. CREB-binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites. Mol Cell Biol 1999;19:3496-505.
27. Lutterbach B, Sun D, Schuetz J, Hiebert SW. The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein. Mol Cell Biol 1998;18:3604-11.
28. White E, Cipriani R, Sabbatini P, Denton A. Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins. J Virol 1991;65:2968-78.
29. Watsuji T, Okamoto Y, Emi N, Katsuoka Y, Hagiwara M. Controlled gene expression with a reverse tetracycline-regulated retroviral vector (RTRV) system. Biochem Biophys Res Commun 1997;234:769-73.
30. Elagib KE, Xiao M, Hussaini IM, et al. Jun blockade of erythropoiesis: role for repression of GATA-1 by HERP2. Mol Cell Biol 2004;24:7779-94.
31. Ravet E, Reynaud D, Titeux M, et al. Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis. Blood 2004; 103:3326-35.
32. Michaud J, Wu F, Osato M, et al. In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial platelet disorder with predisposition to acute myelogenous leukemia: implications for mechanisms of pathogenesis. Blood 2002;99:1364-72.
33. Klisovic ML, Maghraby EA, Parthun MR, et al. Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells. Leukemia 2003;17:350-8.
34. Hong W, Kim AY, Ky S, et al. Inhibition of CBP-mediated protein acetylation by the Ets family onco-protein PU.1. Mol Cell Biol 2002;22:3729-43.
35. Ishiko E, Matsumura I, Ezoe S, et al. Notch signals inhibit the development of erythroid/mega-karyocytic cells by suppressing GATA-1 activity through the induction of HES1. J Biol Chem 2005; 280:4929-39.
36. Mulloy JC, Cammenga J, MacKenzie KL, Berguido FJ, Moore MAS, Nimer SD. The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells. Blood 2002;99:15-23.
37. Lorsbach RB, Moore J, Ang SO, Sun W, Lenny N, Downing JR. Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression. Blood 2004;103:2522-9.
38. Wildonger J, Mann RS. The t(8;21) translocation converts AML1 into a constitutive transcriptional represser. Development 2005;132:2263-72.
39. Wang J, Saunthararajah Y, Redner RL, Liu JM. Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells. Cancer Res 1999;59:2766-9.
40. Ibanez V, Sharma A, Buonamici S, et al. AML1-ETO decreases ETO-2 (MTG 16) interactions with nuclear corepressor, an effect that impairs granulocyte differentiation. Cancer Res 2004;64:4547-54.
41. Zhang J, Kalkum M, Yamamura S, Chait BT, Roeder RG. E protein silencing by the leukemogenic AML1-ETO fusion protein. Science 2004;305:1286-9.
42. Vradii D, Zaidi SK, Lian JB, van Wijnen AJ, Stein JL, Stein GS. Point mutation in AML1 disrupts subnuclear targeting, prevents myeloid differentiation, and effects a transformation-like phenotype. Proc Natl Acad Sci USA 2005;102:7174-9.
43. Cantor AB, Orkin SH. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 2002;21:3368-76.
44. Yanagida M, Osato M, Yamashita N, et al. Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice. Oncogene 2005; 24:4477-85.
45. Chakraborty S, Sinha KK, Senyuk V, Nucifora G. SUV39H1 interacts with AML1 and abrogates AML1 transactivity. AML1 is methylated in vivo. Oncogene 2003;22:5229-37.
46. Lutterbach B, Westendorf JJ, Linggi B, Isaac S, Seto E, Hiebert SW. A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia. J Biol Chem 2000;275:651-6.
47. Alcalay M, Meani N, Gelmetti V, et al. Acute myeloid leukemia fusion proteins deregulate genes involved in stem cell maintenance and DNA repair. J Clin Invest 2003;112:1751-61.
48. Muller-Tidow C, Steifen B, Cauvet T, et al. Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells. Mol Cell Biol 2004;24:2890-904.
49. Kathiriya IS, King IN, Murakami M, et al. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem 2004;279:54937-43.
50. Weng AP, Nam Y, Wolfe MS, et al. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol 2003;23:655-64.