Potential roles for RUNX1 and its orthologs in determining hematopoietic cell fate

Seminars in Cell and Developmental Biology

Volumn 11, Issue 5, 2000, Pages 337-342

  Tracey, W Daniel ^a   Speck, Nancy A ^b  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

AGM; AML1; Hematopoiesis; Lozenge; Runx1

Indexed keywords

CORE BINDING FACTOR; PROTEIN; PROTEIN LOZENGE; PROTEIN RUNX 1; PROTEIN XAML; UNCLASSIFIED DRUG;

ALPHA CHAIN; AMPHIBIA; ANIMAL CELL; BETA CHAIN; CELL FATE; DNA BINDING; DROSOPHILA; FROG; HEMATOPOIESIS; HEMATOPOIETIC CELL; LEUKEMIA; LEUKEMOGENESIS; MOUSE; NONHUMAN; PROTEIN ANALYSIS; REVIEW; XENOPUS;

ANURA; MAMMALIA;

EID: 0034489259     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1006/scdb.2000.0186     Document Type: Article

References (48)

1. A phase and electron microscopic study of vasculogenesis and erythropoiesis in the yolk sac of the mouse
2. Hematopoietic commitment during embryogenesis
3. Ontogeny of the haemopoietic system: Yolk sac origin of in vivo and in vitro colony forming cells in the developing mouse embryo
4. Ontogeny of T cells: Development of pre-T cells from fetal liver and yolk sac in the thymus microenvironment
5. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse
6. Emergence of multipotent hematopoietic cells in the yolk sac and paraaortic splanchnopleura of 8.5 dpc mouse embryos
7. Development of hematopoietic stem cell activity in the mouse embryo
8. Definitive hematopoiesis is autonomously initiated by the AGM region
9. Definitive hematopoietic stem cells first emerge from the major arterial regions of the mouse embryo
10. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
11. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
12. The CBFβ subunit is essential for CBFα2 (AML1) function in vivo
13. Absence of fetal liver hematopoiesis in transcriptional co-activator, core binding factor β (Cbfb) deficient mice
14. Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
15. The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region
16. Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knockin strategy
17. Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins
18. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
19. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
20. Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis
21. The murine allantois
22. Two distinct endothelial lineages in ontogeny, one of them related to hemopoiesis
23. Diffuse intraembryonic hematopoiesis in normal and chimeric avian development
24. Potential intraembryonic hemogenic sites at pre-liver stages in the mouse
25. + hematopoietic cells in the early human embryo
26. Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny
27. In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos
28. Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions
29. A Xenopus homologue of aml-1 reveals unexpected patterning mechanisms leading to the formation of embryonic blood
30. Dual contribution of embryonic ventral blood island and dorsal lateral plate mesoderm during ontogeny of hemopoietic cells in Xenopus laevis
31. Differential participation of ventral and dorsolateral mesoderms in the hemopoiesis of Xenopus, as revealed in diploid-triploid or interspecific chimeras
32. Bipotential primitive-definitive hematopoietic progenitors in the vertebrate embryo
33. Ventral expression of GATA-1 and GATA-2 in the Xenopus embryo defines induction of hematopoietic mesoderm
34. The origins of primitive blood in Xenopus: Implications for axial patterning
35. Elucidating the origins of the vascular system: A fate map of the vascular endothelial and red blood cell lineages in Xenopus laevis
36. Distinct origins of adult and embryonic blood in Xenopus
37. Whole-mount in situ hybridization reveals the expression of the XI-Fli gene in several lineages of migrating cells in Xenopus embryos
38. Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development
39. The SCL gene specifies haemangioblast development from early mesoderm
40. SCL specifies hematopoietic mesoderm in Xenopus embryos
41. Neovascularization of the Xenopus embryo
42. Genetics of a Drosophila phenoloxidase
43. Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1
44. Embryonic origin of hemocytes and their relationship to cell death in Drosophila
45. A molecule aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila
46. Specification of Drosophila hematopietic lineage by conserved transcription factors