A study of chromosome 4p markers and dopamine D5 receptor gene in schizophrenia and bipolar disorder

Molecular Psychiatry

Volumn 3, Issue 4, 1998, Pages 310-320

  Asherson, P ^a,b   Mant, R ^a   Williams, N ^a   Cardno, A ^a   Jones, L ^a   Murphy, K ^a   Collier, D A ^b   Nanko, S ^c   Craddock, N ^a   Morris, S ^d   Muir, W ^d   Blackwood, B ^d   McGuffin, P ^a   Owen, M J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c TEIKYO UNIVERSITY   (Japan)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Association study; Bipolar disorder; Chromosome 4p; Dopamine D5 receptor gene (DRD5); Linkage study; Mutational analysis; Schizophrenia

Indexed keywords

DOPAMINE 5 RECEPTOR;

ARTICLE; CHROMOSOME 4P; CHROMOSOME MARKER; CLINICAL FEATURE; DOMINANT INHERITANCE; GENETIC LINKAGE; HUMAN; MAJOR CLINICAL STUDY; MANIC DEPRESSIVE PSYCHOSIS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR GENE; RECESSIVE INHERITANCE; SCHIZOPHRENIA; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 7344246549     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000399     Document Type: Article

References (39)

1. Asherson P, Mant R, Owen M. A linkage study of the dopamine D5 receptor and schizophrenia. Psychiatric Genet 1995; 5: S46 (Abstract).
2. Blackwood DHR, Morris SW, Mclean A, Whitton C, Thomson M, Walker MT et al. A locus for bipolar disorder on chromosome 4p. Nature Genet 1996; 12: 427-430.
3. Coon H, Byerley W, Holik J, Hoff M, Mylesworsley M, Lannfelt L et al. Linkage analysis of schizophrenia with 5 dopamine receptor genes in 9 pedigrees. Am J Hum Gen 1993; 52: 327-334.
4. Ravindranathan A, Coon H, Delisi L, Holik J, Hoff M, Brown A et al. Linkage analysis between schizophrenia and a microsatellite polymorphism for the D5 dopamine receptor gene. Psychiatric Genet 1994; 4: 77-80.
5. Kalsi G, Sherrington R, Mankoo BS, Brynjolfsson J, Sigmundsson T, Curtis D et al. Linkage study of the D-5 dopamine-receptor gene (DRD5) in multiplex Icelandic and English schizophrenia pedigrees. Am J Psychiatry 1996; 153: 107-109.
6. Williams N, Cardno A, Murphy K, Jones L, Asherson P, McGuffin P et al. Association between schizophrenia and a microsatellite polymorphism at the dopamine D5 receptor gene. Psychiatric Genet 1997; 7: 83-85.
7. Weinshank RI, Adham N, Macchi M, Olsen MAA, Branchek TAA, Hartig PRR. Molecular-cloning and characterization of a high-affinity dopamine receptor (D1-beta) and its pseudogene. J Biol Chem 1991; 266: 22437-22435.
8. Sunahara RK, Guan HC, Odowd BF, Seeman P, Laurier LG, Ng G et al. Cloning of the gene for a human dopamine D5-receptor with higher affinity for dopamine than D1. Nature 1991; 350: 614-619.
9. Beischlag TV, Marchese A, Meadorwoodruff JH, Damask SP, Odowd BF, Tyndale RF et al. The human dopamine D5 receptor gene - cloning and characterization of the 5′-flanking and promoter region. Biochemistry 1995; 34: 5960-5970.
10. Sherrington R, Mankoo B, Attwood J, Kalsi G, Curtis D, Buetow K et al. Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker Raf1p1. Genomics 1993; 18: 423-425.
11. Sobell J, Lind TJ, Sigurdson DC, Zald DH, Snitz BE, Grove WM et al. The D5 dopamine-receptor gene in schizophrenia - identification of a nonsense change and multiple missense changes but lack of association with disease. Hum Molec Genet 1995; 4: 507-514.
12. Carlsson A. The dopamine theory revisited. In: Hirsch S, Weinberger D (eds). Schizophrenia. Blackwell Science: Oxford, 1995, pp 379-400.
13. Beischlag TV, Nam D, Ulpian C, Seeman P, Niznik HB. Polymorphic dinucleotide repeat in the human dopamine D5 receptor gene promoter. Neurosci Lett 1996; 205: 173-176.
14. Gill M, McGuffin P, Parfitt E, Mant R, Asherson P, Collier D et al. A linkage study of schizophrenia with DNA markers from the long arm of chromosome-11. Psych Med 1993; 23: 27-14.
15. Wing J, Cooper JE, Sartorius N. The Measurement and Classification of Psychiatric Symptoms. Cambridge University Press: Cambridge, 1974.
16. McGuffin P, Farmer A, Harvey I. A polydiagnostic application of operational criteria in studies of psychotic illness: development and reliability of the Opcrit system. Arch Gen Psychiatry 1992; 48: 643-647.
17. Spitzer RI, Endicott J, Robin E. Research Diagnostic Criteria For Selected Group of Functional Disorders. New York State Psychiatric Institute: New York, 1978.
18. Clerget-Darpoux F. Effects of misspecifying genetic parameters in lod score analysis. Biometrics 1986; 42: 393-399.
19. McGuffin P, Festenstein H, Murray RM. A family study of HLA antigens and other genetic markers in schizophrenia. Psych Med 1983; 13: 31-43.
20. Asherson P, Mant R, Taylor C, Sargeant M, Collier D, Clements A et al. Failure to find linkage between schizophrenia and genetic-markers on chromosome-21. Am J Med Gen 1993; 48: 161-165.
21. Craddock M, Asherson P, Owen MJ, Williams J, McGuffin P, Farmer AE. Concurrent validity of the OPCRIT diagnostic system. Comparison of OPCRIT diagnoses with consensus best-estimate lifetime diagnoses. Br J Psych 1997; 169: 58-63.
22. Weissenbach J, Gyapay G, Dib C, Vignal A, Morissette J, Millasseau P et al. A second-generation linkage map of the human genome. Nature 1992; 359: 794-801.
23. n dinucleotide repeat polymorphism at the locus for the alpha 2C adrenergic receptor (ADRA2C) on 4p16. Hum Mol Gen 1992; 1: 452.
24. Johnson K, Sander T, Hicks A, Vanmarle A, Janz D, Mullan M et al. Confirmation of the localization of the human Gaba-A-receptor Alpha-1-subunit gene (GABRA1) to distal 5q by linkage analysis. Genomics 1992; 14: 745-748.
25. Lathrop GM, Lalouel JM, Julier C, Ott J. Strategies for multilocus linkage analysis in humans. Proc Natl Acad Sci USA 1984; 81: 3443-3446.
26. Ott J. Analysis of Human Genetic Linkage. John Hopkins University Press: Baltimore, 1985.
27. Owen MJ, Holmans P, McGuffin P. Association studies in psychiatric genetics. Molec Genet 1997; 2: 270-273.
28. Marchese A, Beischlag TV, Nguyen T, Niznik HB, Weinshank RI, George SR et al. Two gene duplication events in the human and primate dopamine D5 receptor gene family. None 1995; 154: 153-158.
29. Mant R. Molecular genetic studies of schizophrenia. PhD thesis, University of Wales, 1995.
30. Asherson P, Mant R, Holmans P, Williams J, Cardno A, Murphy K et al. Linkage, association and mutational analysis of the dopamine D3 receptor gene in schizophrenia. Mol Psychiatry 1996; 1: 125-132.
31. Parfitt E, Asherson P, Roberts E, Mant R, Nanko S, Gill M et al. No evidence for linkage between schizophrenia and 8 microsatellite markers on chromosome-19. Hum Heredity 1996; 46: 191-196.
32. Risch N, Botstein D. A manic depressive history. Nature Genet 1996; 12: 351-353.
33. Kendell RE, Gourlay AJ. The clinical distinction between the affective psychoses and schizophrenia. Br J Psychiatry 1970; 117: 261-266.
34. Kendell RE, Brockington IF. The identification of disease entities and the relationship between schizophrenic and affective psychoses. Br J Psychiatry 1980; 137: 324-331.
35. Crow T. A continuum of psychosis, one human gene, and not much else - the case for homogeneity. Schizophrenia Res 1995; 17: 135-145.
36. Taylor MA. Are schizophrenia and affective disorder related? A selective literature review. Am J Psychiatry 1992; 149: 22-31.
37. Maier W, Lichtermann D, Minges J, Hallmayer J, Heun B, Benkert O et al. Continuity and discontinuity of affective disorders and schizophrenia. Arch Gen Psychiatry 1993; 50: 871-883.
38. McGuffin P, Sargeant M, Hett G, Tidmarsh S, Whatley S, Marchbanks RM. Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11-Q13 region. New data and a reanalysis of previous reports. Am J Human Gen 1990; 47: 524-535.
39. Kelsoe JR, Ginns EI, Egeland JA, Gerhard DS, Goldstein AM, Bale SJ et al. Re-evaluation of the linkage relationship between chromosome 11q loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 1989; 325: 238-243.