mAMSA resistant human topoisomerase IIβ mutation G465D has reduced ATP hydrolysis activity

Nucleic Acids Research

Volumn 34, Issue 5, 2006, Pages 1597-1607

  Gilroy, Kathryn L ^a   Leontiou, Chrysoula ^a   Padget, Kay ^a   Lakey, Jeremy H ^a   Austin, Caroline A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMSACRINE; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ELLIPTICINE; ETOPOSIDE; MAGNESIUM CHLORIDE; N (2 DIMETHYLAMINOETHYL) 4 ACRIDINECARBOXAMIDE; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; DACA, ACRIDINE; DNA; DNA BINDING PROTEIN; DNA TOPOISOMERASE II BETA; ENZYME INHIBITOR;

ANISOTROPY; ARTICLE; CHEMOSENSITIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS RESISTANCE; DNA BINDING; DNA CLEAVAGE; DRUG TARGETING; ENZYME ACTIVITY; GENE MUTATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; PHENOTYPE; PLASMID; POINT MUTATION; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; PROTEIN PURIFICATION; WILD TYPE; DIRECTED MOLECULAR EVOLUTION; DRUG RESISTANCE; FLUORESCENCE POLARIZATION; GENETICS; HYDROLYSIS; METABOLISM;

ACRIDINES; ADENOSINE TRIPHOSPHATE; AMSACRINE; ANTINEOPLASTIC AGENTS; DIRECTED MOLECULAR EVOLUTION; DNA; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DRUG RESISTANCE; ENZYME INHIBITORS; FLUORESCENCE POLARIZATION; HUMANS; HYDROLYSIS; MAGNESIUM CHLORIDE; POINT MUTATION;

EID: 33645471331     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl057     Document Type: Article

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