Mutagenesis of E477 or K505 in the B' domain of human topoisomerase IIβ increases the requirement for magnesium ions during strand passage

Biochemistry

Volumn 39, Issue 6, 2000, Pages 1223-1233

  West, Katherine L ^a,b   Meczes, Emma L ^a   Thorn, Ronald ^a   Turnbull, Rosalind M ^a   Marshall, Richard ^a   Austin, Caroline A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; MAGNESIUM ION;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DNA BINDING; DNA CLEAVAGE; DNA REPLICATION; DNA STRAND BREAKAGE; HUMAN; HYDROLYSIS; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; CATALYSIS; CATIONS, DIVALENT; DNA; DNA TOPOISOMERASES, TYPE II; DNA, FUNGAL; DNA, SUPERHELICAL; DNA-BINDING PROTEINS; GENETIC COMPLEMENTATION TEST; GLUTAMIC ACID; HUMANS; HYDROLYSIS; LYSINE; MAGNESIUM; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 0034673121     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991328b     Document Type: Article

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