Probing the interaction of the cytotoxic bisdioxopiperazine ICRF-193 with the closed enzyme clamp of human topoisomerase IIα

Molecular Pharmacology

Volumn 58, Issue 3, 2000, Pages 560-568

  Patel, Sandhiya ^a   Jazrawi, Elen ^a   Creighton, Andrew M ^b   Austin, Caroline A ^c   Fisher, L Mark ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 BIS(3,5 DIOXO 1 PIPERAZINYL)BUTANE; ALANINE; AMINO ACID; CIRCULAR DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DOUBLE STRANDED DNA; LEUCINE; PHENYLALANINE; PIPERAZINE DERIVATIVE; PROLINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CHROMOSOME SEGREGATION; DNA HELIX; ENZYME ACTIVITY; MITOSIS; MOLECULAR INTERACTION; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

EID: 0033851025     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.3.560     Document Type: Article

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