A human topoisomerase IIα heterodimer with only one ATP binding site can go through successive catalytic cycles

Journal of Biological Chemistry

Volumn 278, Issue 8, 2003, Pages 5768-5774

  Skouboe, Camilla ^c   Bjergbaek, Lotte ^a   Oestergaard, Vibe H ^c   Larsen, Morten K ^b   Knudsen, Birgitta R ^c   Andersen, Anni H ^c  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYMES; HYDROLYSIS; TOPOLOGY;

HETERODIMERS;

BIOCHEMISTRY;

ADENOSINE TRIPHOSPHATE; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE (ATP HYDROLYSING) ALPHA; MUTANT PROTEIN; RAZOXANE; UNCLASSIFIED DRUG; ADENYLYLIMIDODIPHOSPHATE; DNA BINDING PROTEIN; DNA TOPOISOMERASE II ALPHA; PRIMER DNA; RECOMBINANT PROTEIN; TUMOR ANTIGEN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA CLEAVAGE; DNA STRAND; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME PURIFICATION; HUMAN; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; CHEMISTRY; DIMERIZATION; GENETICS; KINETICS; METABOLISM; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PLASMID; POINT MUTATION; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS;

EUKARYOTA; STAPHYLOCOCCUS PHAGE 187;

ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; ANTIGENS, NEOPLASM; BASE SEQUENCE; BINDING SITES; CATALYSIS; CLONING, MOLECULAR; DIMERIZATION; DNA PRIMERS; DNA TOPOISOMERASES, TYPE II, EUKARYOTIC; DNA-BINDING PROTEINS; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; POINT MUTATION; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE;

EID: 0037458744     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210332200     Document Type: Article

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